Silver nanoparticle for biomedical applications: A review

Hybrid Advances, Год журнала: 2024, Номер 6, С. 100184 - 100184

Опубликована: Апрель 21, 2024

Silver nanoparticles are becoming increasingly popular because of their potential applications in bioengineering and medical diagnostics. Nanoparticles possess distinctive features, including increased surface-to-volume ratio superior magnetic properties, which render them well-suited for a range biological uses. They have multi-functionalization, high surface plasmon resonance, large area, stable nature, easy processing. However, silver exciting biomedical applications, biomaterials, detection diagnosis platforms, formulations, drug delivery, device coatings. This typical review provides comprehensive overview the current research on highlighting different methods creating nanoparticles, exploring antimicrobial properties various fields, examining prospective

Язык: Английский

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Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications

Nanomaterials, Год журнала: 2024, Номер 14(20), С. 1618 - 1618

Опубликована: Окт. 10, 2024

Silver nanoparticles (NPs) have become highly promising agents in the field of biomedical science, offering wide therapeutic potential due to their unique physicochemical properties. The characteristics silver NPs, such as higher surface-area-to-volume ratio, make them ideal for a variety biological applications. They are easily processed thanks large surface area, strong plasmon resonance (SPR), stable nature, and multifunctionality. With an emphasis on mechanisms action, efficacy, prospective advantages this review attempts give thorough overview numerous applications these particles. utilization NPs diagnostics, bioimaging biosensing, well functions interventions antimicrobial therapies, cancer therapy, diabetes treatment, bone repair, wound healing, investigated. underlying processes by which exercise effects, oxidative stress induction, apoptosis, microbial cell membrane rupture, explored. Furthermore, toxicological concerns regulatory issues discussed, present difficulties restrictions related application medicine.

Язык: Английский

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Application of AgNPs in biomedicine: An overview and current trends

Nanotechnology Reviews, Год журнала: 2024, Номер 13(1)

Опубликована: Янв. 1, 2024

Abstract Silver nanoparticles (AgNPs) can provide excellent, reliable, and effective solutions for anti-microbial, drug-loading, other purposes due to their extraordinary physical, chemical, biological characteristics. Different methods have been used in the synthesis characterization of AgNPs, AgNPs applied various fields biomedicine, including dentistry, oncology, diabetology, neurodegenerative disorders, so on. However, cytotoxicity has not solved during application, making them controversial. The aim this review is summarize capabilities, synthesis, methods, application biomedicine fields. In addition, toxicity explicated, enhancing benefit properties reducing are demonstrated. end, perspective AgNPs’ research proposed great potential contributing human health.

Язык: Английский

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Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity─A 2024 Update

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Silver nanoparticles (AgNPs) are widely recognized for their unique optical, electronic, and antibacterial properties, enabling use in biosensing, photonics, electronics, drug delivery, antimicrobial treatments. Green chemistry-based biological synthesis methods offer an eco-friendly alternative to traditional chemical techniques. Among metallic (NPs) metal oxides, those derived from plant extracts exhibit notable medicinal properties. Due exceptional stability low reactivity, AgNPs particularly well-suited various applications. can be synthesized through chemical, physical, or methods, each with distinct benefits challenges. Chemical physical approaches often involve complex purification, reactive reagents, high energy demands, while though slower, provide sustainable solutions. The chosen method strongly influences the stability, size, purity of resulting NPs. This review emphasizes importance selecting appropriate optimize characteristics functionality silver It consolidates research spanning past two decades, including most recent findings 2024. A comprehensive electronic search databases such as PubMed, Scopus, ScienceDirect, Cochrane, Google Scholar was conducted up-to-date overview advances applications nanoparticles.

Язык: Английский

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Biomimetic Scaffolds of Calcium-Based Materials for Bone Regeneration

Biomimetics, Год журнала: 2024, Номер 9(9), С. 511 - 511

Опубликована: Авг. 24, 2024

Calcium-based materials, such as calcium carbonate, phosphate, and silicate, have attracted significant attention in biomedical research, owing to their unique physicochemical properties versatile applications. The distinctive characteristics of these including inherent biocompatibility tunable structures, hold promise for applications bone regeneration tissue engineering. This review explores the calcium-containing particularly regeneration. Their remarkable biocompatibility, nanostructures, multifaceted functionalities make them pivotal advancing regenerative medicine, drug delivery system, biomimetic scaffold evolving landscape research continues uncover new possibilities, positioning calcium-based materials key contributors next generation innovative biomaterial scaffolds.

Язык: Английский

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Effect of nanoparticulate CaCO3 on the biological properties of calcium silicate cement

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

This study aimed to evaluate the effects of nanoparticulate CaCO3 (NPCC) on biological properties calcium silicate-based cements (CSCs), including their cytotoxicity, in vitro osteogenic activity, and interactions with rat femur tissue. The average size NPCC was 90.3±26.0 nm. Cytotoxicity activity assays were performed using mouse bone marrow mesenchymal stem cells (BMSCs). BMSCs exposed eluents from CSC alone containing 2.5% (CSC-NPCC (2.5%)) for 24 h showed decreased cell viability at an eluent concentration 75%. In contrast, CSC-NPCCs (5%, 10%, 20%) did not affect viability. Regarding enhanced expression genes, runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP), type I collagen (COL-1), osteocalcin (OCN). Additionally, mineralization cultures by CSC-NPCC, indicating that promoted CSCs. femurs, accelerates resorption stimulates regeneration implantation site. occupied 22.2%±3.25% total femoral area site, whereas CSC-NPCC (20%) only 4%. These histological findings suggest has potential as a biodegradable cement use defect areas require regeneration.

Язык: Английский

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The impact of autogenous bone grafts on the regeneration of radial bone defects in rabbits compared to autogenous advanced platelet-rich fibrin plus.

PubMed, Год журнала: 2025, Номер 15(1), С. 325 - 338

Опубликована: Янв. 1, 2025

Bone grafts are an established treatment performed for managing segmental bone defects resulting from tumors, infections, high-energy trauma, congenital deformities, and nonunion. To determine the regenerative potential following sole implantation of rib, coccygeal, advanced platelet-rich fibrin plus (A-PRF+) autografts to repair radial in rabbits. Radial mid-shaft 10 mm were created on left limb 24 The animals randomly assigned four groups based type defect filling: control (no filler), A-PRF+, rib. Diagnostic imaging modalities, including X-rays computed tomography (CT), with macro- micro-histopathological examinations, employed postoperative assessment at 6 weeks (n = 3) 12 3), respectively. statistical analysis quantitative formation scores diagnostic histopathology postoperatively demonstrated fundamental significance differences between rib coccygeal (p < 0.05). radiographic scoring method indicated a statistically significant difference A-PRF+ 0.01), addition 0.01). In CT evaluation, was observed All quantitatively assessed methods exhibited no postoperatively. At weeks, presented substantial group as evidenced by X-rays, scans, analyses. autograft treat proved significantly enhanced capacity promoting ingrowth. addition, vertebrae serve viable alternative source veterinary surgery. efficacy osseous regeneration treated defects, but it remained inferior autografts.

Язык: Английский

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Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Апрель 11, 2025

Bone marrow is vital for hematopoiesis, producing blood cells essential oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising approach addressing these challenges, particularly in delivery nutraceuticals—bioactive compounds derived from food sources potential benefits. Despite their promise, nutraceuticals face clinical limitations due poor bioavailability, instability, inefficient target sites. Nanoparticles offer viable solution by enhancing stability, absorption, transport bone while minimizing systemic effects. This study explores range disorders, conventional treatment modalities, nanoparticles enhance nutraceutical-based therapies. By improving efficacy, could revolutionize disease management, providing patients effective less invasive options. These advancements represent significant step toward safer efficient approaches, ultimately prognosis overall health.

Язык: Английский

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Antibacterial effect and biocompatibility of silver nanoparticle-coated bone allograft substitutes

Cellular and Molecular Biology, Год журнала: 2024, Номер 70(3), С. 67 - 77

Опубликована: Март 31, 2024

Язык: Английский

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Manufacturing antibacterial Ti-6Al-4V alloys by using NanoAg particles synthesized by reduction method for biomedical applications

Discover Materials, Год журнала: 2024, Номер 4(1)

Опубликована: Окт. 30, 2024

Titanium alloys are among the widely used biomedical materials due to their biocompatibility and mechanical performance. It is an indisputable fact that in this area must be antibacterial. Therefore, study, production of antibacterial using NanoAg particles for use applications was investigated. First, Ti-6Al-4 V titanium were produced by powder metallurgy method, which includes blending, pressing sintering processes. Nano silver synthesized a chemical reduction method nitrate glucose. The resulting solution subjected Ag + ions glucose determinations, pH turbidity analysis. application carried out two different methods; dipping coating method. obtained samples analyzed scanning electron microscopy (SEM) optical microscopy. Additionally, as main purpose analysis against Escherichia Coli Staphylococcus Aureus performed percentage test. While seen more successful tests, overall performance found higher bacteria. Being sample containing 5% with technique showed 100% killing effect both aureus coli.

Язык: Английский

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