Annals of Hepatology, Год журнала: 2024, Номер unknown, С. 101740 - 101740
Опубликована: Ноя. 1, 2024
Язык: Английский
Trends in Pharmacological Sciences, Год журнала: 2023, Номер 45(1), С. 9 - 23
Опубликована: Дек. 7, 2023
Язык: Английский
Процитировано
29
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(9), С. 931 - 931
Опубликована: Авг. 31, 2024
Aging is a fundamental biological process characterized by progressive decline in physiological functions and an increased susceptibility to diseases. Understanding aging at the molecular level crucial for developing interventions that could delay or reverse its effects. This review explores integration of machine learning (ML) with multi-omics technologies-including genomics, transcriptomics, epigenomics, proteomics, metabolomics-in studying hallmarks develop personalized medicine interventions. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis. Using ML analyze big complex datasets helps uncover detailed interactions pathways play role aging. The advances can facilitate discovery biomarkers therapeutic targets, offering insights into anti-aging strategies. With these developments, future points toward better understanding process, aiming ultimately promote healthy extend life expectancy.
Язык: Английский
Процитировано
9
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 17, 2024
The global demographic shift towards an aging population is generating a rise in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent problem. In this landscape, use of natural supplements has garnered attention for their potential dementia prevention. Curcumin (Cur), derived from Curcuma longa, demonstrated promising pharmacological effects against AD by reducing levels inflammatory mediators. However, its clinical efficacy hindered poor solubility and bioavailability. Our study introduces H-Ferritin nanocages (HFn) nanoformulation vehicle Cur, aiming to enhance therapeutic AD. work, we characterized Cur HFn (HFn-CUR) evaluating safety, stability, transport across blood-brain barrier (BBB) vitro. Moreover, evaluated HFn-CUR transcriptomic analysis peripheral blood mononuclear cells (PBMCs) both patients healthy controls (HC), using well-established 5xFAD mouse model data show that exhibits improved water dispersibility, non-toxic, can traverse BBB. Regarding activity on PBMCs patients, enhances cellular responses inflammation reduces RAGE-mediated stress. Studies demonstrate mild beneficial cognitive performance. it effectively microgliosis astrogliosis vivo mouse, suggesting neuroprotective benefits. suggest safe effective vitro models AD, supporting need further experiments define optimal use.
Язык: Английский
Процитировано
4
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102734 - 102734
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Innovation, Год журнала: 2025, Номер 20(2)
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2024, Номер 987, С. 177186 - 177186
Опубликована: Дек. 6, 2024
Язык: Английский
Процитировано
2
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116837 - 116837
Опубликована: Май 29, 2024
Hyperglycemic stress can directly lead to neuronal damage. The mechanosensitive ion channel PIEZO1 be activated in response hyperglycemia, but its role hyperglycemic neurotoxicity is unclear. of was explored by constructing a mouse model and high-glucose HT22 cell model. results showed that significantly upregulated high glucose stress. In vitro experiments have shown induces changes morphology membrane tension, key mechanism for activation. addition, upregulates serum/glucocorticoid-regulated kinase-1 (SGK1) activates through the Ca
Язык: Английский
Процитировано
1
Neuropeptides, Год журнала: 2024, Номер 107, С. 102450 - 102450
Опубликована: Июнь 22, 2024
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(24), С. 5936 - 5936
Опубликована: Дек. 16, 2024
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive dysfunction, memory decline, and behavioral disturbance, it pathologically characterized by the accumulation of amyloid plaques neurofibrillary tangles in brain. Although various hypotheses have been proposed to explain pathogenesis AD, including beta hypothesis, oxidative stress abnormal phosphorylation tau proteins, exact pathogenic mechanisms underlying AD remain largely undefined. Furthermore, effective curative treatments are very limited. Epidemiologic studies provide convincing evidence for significant association between type 2 diabetes AD. Here, we showed energy metabolism using glucose, lactate, ketone bodies, lipids as substrates normal brain, changes such due diabetes. We also influences altered on pathology comprehensively searched risk factors related possible therapeutic interventions based considering brain development
Язык: Английский
Процитировано
1
Annals of Hepatology, Год журнала: 2024, Номер unknown, С. 101740 - 101740
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0