Brain reserve in hepatic encephalopathy: pathways of damage and preventive strategies through lifestyle and therapeutic interventions DOI Creative Commons
Jacqueline Córdova‐Gallardo,

Andres Manuel Vargas-Beltran,

Samantha Melanie Armendariz-Pineda

et al.

Annals of Hepatology, Journal Year: 2024, Volume and Issue: unknown, P. 101740 - 101740

Published: Nov. 1, 2024

Language: Английский

PPAR agonists for the treatment of neuroinflammatory diseases DOI

Celene Titus,

Md. Tozammel Hoque, Reina Bendayan

et al.

Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 45(1), P. 9 - 23

Published: Dec. 7, 2023

Language: Английский

Citations

29
Integrating Machine Learning with Multi-Omics Technologies in Geroscience: Towards Personalized Medicine DOI Open Access
Nikolaos Theodorakis, Georgios Feretzakis, Lazaros Tzelves

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 931 - 931

Published: Aug. 31, 2024

Aging is a fundamental biological process characterized by progressive decline in physiological functions and an increased susceptibility to diseases. Understanding aging at the molecular level crucial for developing interventions that could delay or reverse its effects. This review explores integration of machine learning (ML) with multi-omics technologies-including genomics, transcriptomics, epigenomics, proteomics, metabolomics-in studying hallmarks develop personalized medicine interventions. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, dysbiosis. Using ML analyze big complex datasets helps uncover detailed interactions pathways play role aging. The advances can facilitate discovery biomarkers therapeutic targets, offering insights into anti-aging strategies. With these developments, future points toward better understanding process, aiming ultimately promote healthy extend life expectancy.

Language: Английский

Citations

9
Exploring the anti-inflammatory effects of curcumin encapsulated within ferritin nanocages: a comprehensive in vivo and in vitro study in Alzheimer’s disease DOI Creative Commons
Carlo Morasso, Marta Truffi, Veronica Tinelli

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 17, 2024

The global demographic shift towards an aging population is generating a rise in neurodegenerative conditions, with Alzheimer's disease (AD) as the most prominent problem. In this landscape, use of natural supplements has garnered attention for their potential dementia prevention. Curcumin (Cur), derived from Curcuma longa, demonstrated promising pharmacological effects against AD by reducing levels inflammatory mediators. However, its clinical efficacy hindered poor solubility and bioavailability. Our study introduces H-Ferritin nanocages (HFn) nanoformulation vehicle Cur, aiming to enhance therapeutic AD. work, we characterized Cur HFn (HFn-CUR) evaluating safety, stability, transport across blood-brain barrier (BBB) vitro. Moreover, evaluated HFn-CUR transcriptomic analysis peripheral blood mononuclear cells (PBMCs) both patients healthy controls (HC), using well-established 5xFAD mouse model data show that exhibits improved water dispersibility, non-toxic, can traverse BBB. Regarding activity on PBMCs patients, enhances cellular responses inflammation reduces RAGE-mediated stress. Studies demonstrate mild beneficial cognitive performance. it effectively microgliosis astrogliosis vivo mouse, suggesting neuroprotective benefits. suggest safe effective vitro models AD, supporting need further experiments define optimal use.

Language: Английский

Citations

4
Impact of Diet and Exercise on Mitochondrial Quality and Mitophagy in Alzheimer's disease DOI
Jangampalli Adi Pradeepkiran, Md. Ariful Islam,

Ujala Sehar

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102734 - 102734

Published: March 1, 2025

Language: Английский

Citations

0
Enhancement of Solubility and Bioavailability of Bezafibrate Based on Hydrotropy and Solid Dispersion Technique DOI
Jie Liu, Quan Liu, Zhibing Zhang

et al.

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)

Published: April 1, 2025

Language: Английский

Citations

0
Protective effects of the PPAR agonist bezafibrate against disruption of redox and energy homeostasis, neuronal death, astroglial reactivity, and neuroinflammation induced in vivo by D-2-hydroxyglutaric acid in rat brain DOI
Rafael Teixeira Ribeiro, Manuela Bianchin Marcuzzo, Andrey Vinícios Soares Carvalho

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 987, P. 177186 - 177186

Published: Dec. 6, 2024

Language: Английский

Citations

2
PIEZO1 as a new target for hyperglycemic stress-induced neuropathic injury: The potential therapeutic role of bezafibrate DOI Open Access
Hailin Liu, Lian Zhou, Xifeng Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116837 - 116837

Published: May 29, 2024

Hyperglycemic stress can directly lead to neuronal damage. The mechanosensitive ion channel PIEZO1 be activated in response hyperglycemia, but its role hyperglycemic neurotoxicity is unclear. of was explored by constructing a mouse model and high-glucose HT22 cell model. results showed that significantly upregulated high glucose stress. In vitro experiments have shown induces changes morphology membrane tension, key mechanism for activation. addition, upregulates serum/glucocorticoid-regulated kinase-1 (SGK1) activates through the Ca

Language: Английский

Citations

1
Bezafibrate protects blood-brain barrier (BBB) integrity against traumatic brain injury mediated by AMPK DOI

Xiubao Yang,

Qingyong Chang,

Yan Wang

et al.

Neuropeptides, Journal Year: 2024, Volume and Issue: 107, P. 102450 - 102450

Published: June 22, 2024

Language: Английский

Citations

1
Pathology and Treatments of Alzheimer’s Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes DOI Creative Commons
Hidekatsu Yanai,

Hiroki Adachi,

Mariko Hakoshima

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5936 - 5936

Published: Dec. 16, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive dysfunction, memory decline, and behavioral disturbance, it pathologically characterized by the accumulation of amyloid plaques neurofibrillary tangles in brain. Although various hypotheses have been proposed to explain pathogenesis AD, including beta hypothesis, oxidative stress abnormal phosphorylation tau proteins, exact pathogenic mechanisms underlying AD remain largely undefined. Furthermore, effective curative treatments are very limited. Epidemiologic studies provide convincing evidence for significant association between type 2 diabetes AD. Here, we showed energy metabolism using glucose, lactate, ketone bodies, lipids as substrates normal brain, changes such due diabetes. We also influences altered on pathology comprehensively searched risk factors related possible therapeutic interventions based considering brain development

Language: Английский

Citations

1
Brain reserve in hepatic encephalopathy: pathways of damage and preventive strategies through lifestyle and therapeutic interventions DOI Creative Commons
Jacqueline Córdova‐Gallardo,

Andres Manuel Vargas-Beltran,

Samantha Melanie Armendariz-Pineda

et al.

Annals of Hepatology, Journal Year: 2024, Volume and Issue: unknown, P. 101740 - 101740

Published: Nov. 1, 2024

Language: Английский

Citations

0