Bacterial extracellular vesicles in osteoarthritis: a new bridge of the gut-joint axis
Gut Microbes,
Год журнала:
2025,
Номер
17(1)
Опубликована: Апрель 11, 2025
Osteoarthritis
(OA)
is
a
degenerative
joint
disease
primarily
characterized
by
cartilage
degeneration.
Increasing
evidence
suggests
that
there
an
interplay
between
the
gut
microbiota
(GM)
and
health,
known
as
gut-joint
axis.
In
recent
years,
with
advancement
of
bacterial
extracellular
vesicles
(BEVs)
research,
its
role
in
axis
has
attracted
increasing
attention.
BEVs
are
phospholipid
bilayer
nanocarriers
sizes
ranging
from
20
to
400
nm,
which
can
deliver
various
bioactive
molecules
modulate
intestinal
microenvironments.
Due
nanoscale
structure,
low
toxicity,
high
drug
loading
capacity,
good
biocompatibility,
easy
modification,
industrialization,
promising
for
OA
treatment.
Here,
we
reviewed
research
status
including
biogenies,
classification,
structures,
composition,
summarized
cargo
within
associated
OA.
The
application
natural
treatment
core,
separation,
purification,
modification
strategies
engineered
summarized.
Finally,
provide
overview
prospects
clinical
diagnosis
We
hope
comprehensive
understanding
will
new
solutions
Язык: Английский
Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 11, 2024
Ferroptosis,
an
iron-ion-dependent
process
of
lipid
peroxidation,
damages
the
plasma
membrane,
leading
to
non-programmed
cell
death.
Osteoarthritis
(OA),
a
prevalent
chronic
degenerative
joint
disease
among
middle-aged
and
older
adults,
is
characterized
by
chondrocyte
damage
or
loss.
Emerging
evidence
indicates
that
ferroptosis
plays
role
in
OA
development.
However,
most
research
has
concentrated
on
regulation
involving
typical
iron
ions,
potentially
neglecting
significance
elevated
copper
ions
both
serum
fluid
patients
with
OA.
This
review
aims
fill
this
gap
systematically
examining
interplay
between
metabolism,
oxidative
stress,
ferroptosis,
copper-associated
death
It
will
provide
comprehensive
overview
ions'
regulating
their
dual
approach
seeks
offer
new
insights
for
further
research,
prevention,
treatment
Язык: Английский
Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 5, 2024
Osteoarthritis
(OA)
is
a
progressive
degenerative
disorder
impacting
bones
and
joints,
worsened
by
chronic
inflammation,
immune
dysregulation,
mechanical
stress,
metabolic
disturbances,
various
other
contributing
factors.
The
complex
interplay
of
cartilage
damage,
loss,
impaired
repair
mechanisms
remains
critical
formidable
aspect
OA
pathogenesis.
At
the
genetic
level,
multiple
genes
have
been
implicated
in
modulation
chondrocyte
metabolism,
displaying
both
promotive
inhibitory
roles.
Recent
research
has
increasingly
focused
on
influence
non-coding
RNAs
regulation
distinct
cell
types
within
bone
tissue
OA.
In
particular,
an
expanding
body
evidence
highlights
regulatory
roles
microRNAs
chondrocytes.
This
review
aims
to
consolidate
most
relevant
associated
with
chondrocytes,
as
identified
recent
studies,
elucidate
their
involvement
processes
ferroptosis.
Furthermore,
this
study
explores
interactions
between
long
(lncRNAs)
circular
(circRNAs)
OA,
emphasis
microRNA-mediated
mechanisms.
Finally,
gaps
current
are
identified,
offering
strategic
insights
advance
understanding
pathophysiology
guide
therapeutic
developments
field.
Язык: Английский
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 18, 2024
Osteoarthritis
(OA)
is
one
of
the
leading
causes
disability
worldwide,
characterized
by
a
complex
pathological
process
involving
cartilage
degradation,
synovial
inflammation,
and
subchondral
bone
remodeling.
In
recent
years,
ferroptosis,
form
programmed
cell
death
driven
iron-dependent
lipid
peroxidation,
has
been
recognized
as
playing
critical
role
in
onset
progression
OA.
Investigating
molecular
mechanisms
ferroptosis
its
involvement
OA
may
offer
novel
strategies
for
diagnosing
treating
this
disease.
This
review
first
outlines
core
with
particular
focus
on
roles
molecules
such
Glutathione
Peroxidase
4
(GPX4),
Transferrin
Receptor
1
(TfR1),
Nuclear
Coactivator
(NCOA4).
Subsequently,
study
examines
specific
impacts
pathophysiology
Building
this,
potential
ferroptosis-related
biomarkers
diagnosis
treatment
highlighted,
along
proposed
therapeutic
targeting
regulation.
aims
to
deepen
understanding
advance
clinical
application
regulatory
therapies
Язык: Английский