Clinical and Experimental Obstetrics & Gynecology,
Год журнала:
2024,
Номер
51(9)
Опубликована: Сен. 14, 2024
Objective:
This
review
summarizes
the
molecular
properties,
anticancer
effects,
and
bioavailability
of
quercetin
(Que).
We
discussed
its
role
in
preventing
treating
gynecologic
cancers,
assisting
treatment
drug-resistant
cases,
synergizing
with
other
treatments.
includes
an
analysis
Que’s
impact
on
breast,
ovarian,
cervical
cancer.
Mechanism:
Gynecologic
cancers
are
a
significant
cause
cancer-related
deaths,
leading
to
low
survival
rates
high
burden
patients
healthcare
systems.
They
regarded
as
major
health
problem
women.
The
use
complementary
therapies,
such
Que,
can
contribute
improving
patient
outcomes
quality
life.
utilization
medicinal
plants
alternative
medicine
(CAM)
is
rise
worldwide,
offering
new
approaches
cancer
treatment.
approach
may
provide
potential
treatments
for
various
including
female
cancer,
either
alone
or
combination
medications.
Findings
Brief:
Among
natural
compounds,
Que
commonly
used
anti-cancer
supplement
due
antioxidant
anti-inflammatory
properties.
effective
dose-
time-dependent
manner,
demonstrated
by
numerous
vitro
vivo
studies
experiments.
However,
more
clinical
required
establish
this
flavonoid
therapeutic
agent
part
drug
humans.
Conclusions:
helps
prevent
treat
gynecological
reduce
resistance,
increase
effectiveness
chemical
drugs
radiotherapy.
It
achieves
through
anti-inflammatory,
pro-oxidative,
anti-proliferative,
induction
apoptosis,
cell
cycle
arrest
mechanisms.
human
needed
accurately
determine
mechanisms
action
extent
effectiveness.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
21(6), С. 905 - 920
Опубликована: Июнь 2, 2024
Introduction
This
review
discusses
novel
hybrid
assemblies
that
are
based
on
liposomal
formulations.
The
focus
is
the
constructs
formed
through
integration
of
liposomes/vesicles
with
other
nano-objects
such
as
nucleic
acid
nanostructures
and
metallic
nanoparticles.
aim
to
introduce
some
recent,
specific
examples
bridge
different
technologies
thus
may
form
a
new
platform
for
advanced
drug
delivery
applications.
Drug Development and Industrial Pharmacy,
Год журнала:
2024,
Номер
50(7), С. 671 - 686
Опубликована: Июль 2, 2024
This
study
was
aimed
to
develop
a
cationic
lipoplex
formulation
loaded
with
Nintedanib
and
miR-29b
(LP-NIN-miR)
as
an
alternative
approach
in
the
combination
therapy
of
idiopathic
pulmonary
dibrosis
(IPF)
by
proving
its
additive
anti-fibrotic
therapeutic
effects
through
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1156 - 1156
Опубликована: Авг. 31, 2024
Glioblastoma
multiforme
(GBM)
is
the
most
severe
form
of
brain
cancer
in
adults,
characterized
by
its
complex
vascular
network
that
contributes
to
resistance
conventional
therapies.
Thermal
therapies,
such
as
magnetic
hyperthermia
(MHT),
emerge
promising
alternatives,
using
heat
selectively
target
tumor
cells
while
minimizing
damage
healthy
tissues.
The
organ-on-a-chip
can
replicate
this
GBM,
allowing
for
detailed
investigations
dissipation
MHT,
computational
simulations
refine
treatment
parameters.
In
silico
study,
tumor-on-a-chip
models
were
used
optimize
MHT
therapy
comparing
normal
and
abnormal
networks,
considering
geometries,
flow
rates,
concentrations
nanoparticles
(MNPs).
high
complexity
model,
maximum
velocity
was
19
times
lower
than
vasculature
model
4
low-complexity
highlighting
influence
on
temperature
distribution.
simulation
showed
greater
intensity
central
region,
with
a
rate
1
µL/min
0.5
mg/mL
MNPs
being
best
conditions
achieve
therapeutic
temperature.
had
lowest
dissipation,
reaching
44.15
°C,
compared
42.01
°C
37.80
model.
These
results
show
improves
retention,
making
it
essential
consider
heterogeneity
treatment.
Therefore,
an
efficient
process,
necessary
simulate
ideal
blood
MNP
ensure
retention
at
site,
irregular
vascularization
effective
destruction.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 25, 2024
Abstract
Tumors
are
considered
dangerous
due
to
their
significant
global
mortality
rate,
with
breast
cancer
(BC)
being
a
major
contributor
this
statistic,
impacting
almost
all
tumor
patients
worldwide.
Conventional
methods
for
BC
treatment,
such
as
special
naringin
(NG)
chemotherapy
based
on
nanotechnology
components,
have
been
insufficient,
and
new
approach
has
used
improve
drug
delivery
(DD)
cancer.
Herein,
developed
biocompatible
nanoparticles
(NPs)
comprising
NG-loaded
zinc
metal-organic
framework-5
(NG-MOF-5)
encapsulated
liponiosomes
(LNs)
create
NG-MOF-5@LNs.
Various
biophysical
characteristics
of
free
NG,
MOF-5,
NG-MOF-5@LNs
NPs
were
studied,
including
XRD,
FTIR,
TEM,
SEM,
zeta
potential
(ZP),
hydrodynamic
size,
PDI,
loading
efficiency
(LE),
encapsulation
(EE),
release
(DR),
drug-release
kinetics.
TEM
images
showed
that
consisted
monodispersed
spherical-like
particles
average
diameters
122.5
nm
(*P
<
0.05).
The
optimized
exhibited
particle
size
(PDI:
139.8
nm)
ZP
(+
21
mV).
EE
LE
89.15%
14.05%,
respectively.
Four
kinetic
models
examined
understand
the
NG
mechanism
at
pH
6.9,
Higuchi
model
indicating
excellent
fit
(R2
=
0.9988).
MTT
cell
viability
assay
demonstrated
anti-cancer
activity
against
MCF-7
cells,
inhibitory
concentrations
(IC50)
231.9,
188.2,
21.6
µg/mL
0.05)
NG-MOF-5@LNs,
respectively,
an
apoptosis
effect
cells.
is
expected
emerge
novel
long-term-release
anticancer
agent.
may
represent
superior
option
therapy
compared
conventional
formulations.
Clinical and Experimental Obstetrics & Gynecology,
Год журнала:
2024,
Номер
51(9)
Опубликована: Сен. 14, 2024
Objective:
This
review
summarizes
the
molecular
properties,
anticancer
effects,
and
bioavailability
of
quercetin
(Que).
We
discussed
its
role
in
preventing
treating
gynecologic
cancers,
assisting
treatment
drug-resistant
cases,
synergizing
with
other
treatments.
includes
an
analysis
Que’s
impact
on
breast,
ovarian,
cervical
cancer.
Mechanism:
Gynecologic
cancers
are
a
significant
cause
cancer-related
deaths,
leading
to
low
survival
rates
high
burden
patients
healthcare
systems.
They
regarded
as
major
health
problem
women.
The
use
complementary
therapies,
such
Que,
can
contribute
improving
patient
outcomes
quality
life.
utilization
medicinal
plants
alternative
medicine
(CAM)
is
rise
worldwide,
offering
new
approaches
cancer
treatment.
approach
may
provide
potential
treatments
for
various
including
female
cancer,
either
alone
or
combination
medications.
Findings
Brief:
Among
natural
compounds,
Que
commonly
used
anti-cancer
supplement
due
antioxidant
anti-inflammatory
properties.
effective
dose-
time-dependent
manner,
demonstrated
by
numerous
vitro
vivo
studies
experiments.
However,
more
clinical
required
establish
this
flavonoid
therapeutic
agent
part
drug
humans.
Conclusions:
helps
prevent
treat
gynecological
reduce
resistance,
increase
effectiveness
chemical
drugs
radiotherapy.
It
achieves
through
anti-inflammatory,
pro-oxidative,
anti-proliferative,
induction
apoptosis,
cell
cycle
arrest
mechanisms.
human
needed
accurately
determine
mechanisms
action
extent
effectiveness.
