Magnetite nanoparticles coated with glycerin for use in hyperthermia-based cancer treatment DOI

Saleh Fallah Samakosh,

Ali Bahari,

Vaheed Fallah Hamidabadi

et al.

Emergent Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles DOI
Olavi Reinsalu, Mart Ernits, Veikko Linko

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(6), P. 905 - 920

Published: June 2, 2024

Introduction This review discusses novel hybrid assemblies that are based on liposomal formulations. The focus is the constructs formed through integration of liposomes/vesicles with other nano-objects such as nucleic acid nanostructures and metallic nanoparticles. aim to introduce some recent, specific examples bridge different technologies thus may form a new platform for advanced drug delivery applications.

Language: Английский

Citations

2
Enhanced efficacy of quercetin and taxifolin encapsulated with pH-responsive injectable BSA hydrogel for targeting triple-negative breast cancer cells DOI

Durga Bhavani Kundrapu,

Podilapu Atchutha Rao, Rama Rao Malla

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138477 - 138477

Published: Dec. 11, 2024

Language: Английский

Citations

2
Nintedanib and miR-29b co-loaded lipoplexes in idiopathic pulmonary fibrosis: formulation, characterization, and in vitro evaluation DOI

Ceren Duraloglu,

İpek Baysal,

Samiye Yabanoğlu‐Çiftçi

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2024, Volume and Issue: 50(7), P. 671 - 686

Published: July 2, 2024

This study was aimed to develop a cationic lipoplex formulation loaded with Nintedanib and miR-29b (LP-NIN-miR) as an alternative approach in the combination therapy of idiopathic pulmonary dibrosis (IPF) by proving its additive anti-fibrotic therapeutic effects through

Language: Английский

Citations

1
In Silico Approach to Model Heat Distribution of Magnetic Hyperthermia in the Tumoral and Healthy Vascular Network Using Tumor-on-a-Chip to Evaluate Effective Therapy DOI Creative Commons
Juan Matheus Munoz,

Giovana Fontanella Pileggi,

Mariana Penteado Nucci

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1156 - 1156

Published: Aug. 31, 2024

Glioblastoma multiforme (GBM) is the most severe form of brain cancer in adults, characterized by its complex vascular network that contributes to resistance conventional therapies. Thermal therapies, such as magnetic hyperthermia (MHT), emerge promising alternatives, using heat selectively target tumor cells while minimizing damage healthy tissues. The organ-on-a-chip can replicate this GBM, allowing for detailed investigations dissipation MHT, computational simulations refine treatment parameters. In silico study, tumor-on-a-chip models were used optimize MHT therapy comparing normal and abnormal networks, considering geometries, flow rates, concentrations nanoparticles (MNPs). high complexity model, maximum velocity was 19 times lower than vasculature model 4 low-complexity highlighting influence on temperature distribution. simulation showed greater intensity central region, with a rate 1 µL/min 0.5 mg/mL MNPs being best conditions achieve therapeutic temperature. had lowest dissipation, reaching 44.15 °C, compared 42.01 °C 37.80 model. These results show improves retention, making it essential consider heterogeneity treatment. Therefore, an efficient process, necessary simulate ideal blood MNP ensure retention at site, irregular vascularization effective destruction.

Language: Английский

Citations

1
Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells DOI
Shehab Elbeltagi, Hanan M. Alharbi, Alhassan H. Aodah

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Abstract Tumors are considered dangerous due to their significant global mortality rate, with breast cancer (BC) being a major contributor this statistic, impacting almost all tumor patients worldwide. Conventional methods for BC treatment, such as special naringin (NG) chemotherapy based on nanotechnology components, have been insufficient, and new approach has used improve drug delivery (DD) cancer. Herein, developed biocompatible nanoparticles (NPs) comprising NG-loaded zinc metal-organic framework-5 (NG-MOF-5) encapsulated liponiosomes (LNs) create NG-MOF-5@LNs. Various biophysical characteristics of free NG, MOF-5, NG-MOF-5@LNs NPs were studied, including XRD, FTIR, TEM, SEM, zeta potential (ZP), hydrodynamic size, PDI, loading efficiency (LE), encapsulation (EE), release (DR), drug-release kinetics. TEM images showed that consisted monodispersed spherical-like particles average diameters 122.5 nm (*P < 0.05). The optimized exhibited particle size (PDI: 139.8 nm) ZP (+ 21 mV). EE LE 89.15% 14.05%, respectively. Four kinetic models examined understand the NG mechanism at pH 6.9, Higuchi model indicating excellent fit (R2 = 0.9988). MTT cell viability assay demonstrated anti-cancer activity against MCF-7 cells, inhibitory concentrations (IC50) 231.9, 188.2, 21.6 µg/mL 0.05) NG-MOF-5@LNs, respectively, an apoptosis effect cells. is expected emerge novel long-term-release anticancer agent. may represent superior option therapy compared conventional formulations.

Language: Английский

Citations

0
Magnetic iron oxide platforms associated with phytochemicals for applications in MRI and magnetic hyperthermia: A comprehensive review DOI

Giovanna Nogueira da Silva Avelino Oliveira Rocha,

Julia Fernanda da Costa Araujo,

José Yago Rodrigues Silva

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106224 - 106224

Published: Sept. 21, 2024

Language: Английский

Citations

0
The Effect of Quercetin on the Prevention and Treatment of Gynecologic Cancer DOI Creative Commons

Arezou Biyabani,

Afrooz Mazidimoradi,

Fereshte Ghorbani

et al.

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 51(9)

Published: Sept. 14, 2024

Objective: This review summarizes the molecular properties, anticancer effects, and bioavailability of quercetin (Que). We discussed its role in preventing treating gynecologic cancers, assisting treatment drug-resistant cases, synergizing with other treatments. includes an analysis Que’s impact on breast, ovarian, cervical cancer. Mechanism: Gynecologic cancers are a significant cause cancer-related deaths, leading to low survival rates high burden patients healthcare systems. They regarded as major health problem women. The use complementary therapies, such Que, can contribute improving patient outcomes quality life. utilization medicinal plants alternative medicine (CAM) is rise worldwide, offering new approaches cancer treatment. approach may provide potential treatments for various including female cancer, either alone or combination medications. Findings Brief: Among natural compounds, Que commonly used anti-cancer supplement due antioxidant anti-inflammatory properties. effective dose- time-dependent manner, demonstrated by numerous vitro vivo studies experiments. However, more clinical required establish this flavonoid therapeutic agent part drug humans. Conclusions: helps prevent treat gynecological reduce resistance, increase effectiveness chemical drugs radiotherapy. It achieves through anti-inflammatory, pro-oxidative, anti-proliferative, induction apoptosis, cell cycle arrest mechanisms. human needed accurately determine mechanisms action extent effectiveness.

Language: Английский

Citations

0
Magnetite nanoparticles coated with glycerin for use in hyperthermia-based cancer treatment DOI

Saleh Fallah Samakosh,

Ali Bahari,

Vaheed Fallah Hamidabadi

et al.

Emergent Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

Citations

0