Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 103, С. 106429 - 106429
Опубликована: Ноя. 22, 2024
Язык: Английский
Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10916 - 10940
Опубликована: Май 29, 2024
Язык: Английский
Процитировано
10
Phytotherapy Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate neurons the form tangles. The pathophysiological pathway AD consists Aβ-amyloid peptides, proteins, oxidative stress increased neuro-inflammatory response. Food Drug Administration United States has authorized various drugs for effective treatment AD, include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, aducanumab. major disadvantage these that they only provide "symptomatic" relief. They are most early stages or mild to moderate cases disease, but not suitable long-term use. Besides conventional therapies, phytochemicals have potential stop progression AD. According research, use against gained attention due their potent anti-inflammatory, antioxidant, anti-hyperphosphorylation protein, metal chelation, anti-amyloid properties. This study seeks an up-to-date compilation current promising breakthroughs therapy using phytochemicals. It could be concluded light serve as However, more mechanistic investigations needed determine clinical implications treatment.
Язык: Английский
Процитировано
1
CNS & Neurological Disorders - Drug Targets, Год журнала: 2024, Номер 23(10), С. 1251 - 1262
Опубликована: Фев. 14, 2024
Abstract: The potential of nanotechnology in advancing the diagnosis and treatment neurodegenerative diseases is explored this comprehensive literature review. findings these studies suggest that has capacity to improve existing therapeutic approaches, create novel safe compounds, develop more precise imaging techniques diagnostic methods for diseases. With emergence nanomedicine era, a new innovative approach diagnosing treating conditions been introduced. Notably, researchers' development nanocarrier drug delivery tool demonstrates immense compared conventional therapy, as it maximizes efficacy minimizes undesirable side effects.
Язык: Английский
Процитировано
5
Heliyon, Год журнала: 2024, Номер 10(4), С. e26351 - e26351
Опубликована: Фев. 1, 2024
Alzheimer's disease is a neurological disorder that causes increased memory loss, mood swings, behavioral disorders, and disruptions in daily activities. Polymer scaffolds for the brain have been grown under laboratory, physiological, pathological circumstances because of limitations conventional treatments patients with central nervous system diseases. The blood-brain barrier prevents medications from entering brain, challenging AD treatment. Numerous biomaterials such as biomolecules, polymers, inorganic metals, metal oxide nanoparticles used to transport therapeutic medicines into system. Incorporating biocompatible materials support neurogenesis through combination topographical, pharmacological, mechanical stimuli has also shown promise transfer cells replenish dopaminergic neurons. Components made naturally occurring biodegradable polymers are appropriate regeneration nerve tissue. ability natural-based (biomaterials) promote endogenous cell development after implantation. Also, strategic functionalization polymeric nanocarriers could be employed treating AD. In particular, resolve Aβ aggregation thus help cure disease. Drug moieties can effectively directed by utilizing nano-based systems diverse colloidal carriers, including hydrogels scaffolds. Notably, early investigations employing neural stem yielded promising results, further emphasizing potential advancements this field. Few studies fully leveraged cutting-edge biomaterials. This study provides comprehensive overview prior research, highlighting pivotal role sophisticated drug carriers. It delves various intelligent delivery systems, encompassing pH thermo-triggered mechanisms, lipid nanoparticles, other vectors. discussion synthesizes existing knowledge underscores transformative impact these devising innovative strategies, augmenting current methodologies, shaping new paradigms realm
Язык: Английский
Процитировано
5
NeuroMarkers., Год журнала: 2025, Номер 2(2), С. 100041 - 100041
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
0
Open Journal of Biophysics, Год журнала: 2024, Номер 14(02), С. 121 - 131
Опубликована: Янв. 1, 2024
The objectives of this study are to understand the mechanisms involved in stabilization water/oil interfaces by polymeric nanoparticles (NPs) (Eudragit®). Eudragit L100 NPs various sizes and Zeta potentials were studied compared at a water/cyclohexane model interface using droplet tensiometer (Tracker Teclis, Longessaigne, France). progressive interfacial adsorption aqueous phase was monitored tensiometry. maintained observed drop tensiometer, analyzed via axisymmetric shape analysis (ADSA), determine properties. Given direct relationship between stability Pickering emulsions (emulsions stabilized solid nanoparticles) properties these layers, different nanoparticle systems compared. Specifically, examined. Moreover, reduction potential with PEG-6000 induces partial aggregation (referred as NP flocs), significantly impacting layer. Dynamic surface tension measurements indicate significant decrease Eudragit® (NPs). This correlates size NPs, highlighting that parameter does not operate isolation. Other factors, such contact angle wettability nanoparticles, also play critical role. Notably, larger further diminished tension. enhances our understanding nanoparticles.
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 103, С. 106429 - 106429
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
0