Potential treatment of glutathione in bullfrogs with abnormal hepatic lipid metabolism revealed by hepatic lipid metabolism and serum metabolomics analysis DOI Creative Commons

Zehui Su,

Fu Gao, Rui Shu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Авг. 13, 2024

Introduction With the continuous growth of bullfrog supply, it has become an important aquaculture species. Due to lack actionable industry standards and regulation, misuse anti-disease drugs abnormal liver lipid metabolism in bullfrogs have a major obstacle development industry. Glutathione is natural tripeptide that can be synthesized intracellularly, its physiological functions mainly include treatment diseases, antioxidant, detoxification, anti-tumor, enhancement immunity, delaying aging. Methods In this study, therapeutic effect glutathione on with was revealed from hepatic serum metabolomics analysis. The survival rate, histomorphology, antioxidant enzyme activity, lipase activity metabolomics, were studied analyzed by feeding for 20 days NC, FI GSH groups. Results results study showed able repair improve rate metabolism; SOD enzymes significantly increased; activities ACP AKP decreased; HDL-C T-CHO LDL-C, TBA, TG decreased liver; contents metabolites, such as PC, PS, PE up-regulated, levels up-regulated Autophagy - other, Necroptosis ErbB signaling pathway, down-regulated Sphingolipid metabolism, D-Amino acid metabolic some extent pathways alleviate disorders glycerophospholipid amino certain extent, thus alleviating abnormalities metabolism. Discussion could effectively treat disorder bullfrogs, promote function, reduce inflammation, healthy green

Язык: Английский

Medicinal Potential of Broussonetia papyrifera: Chemical Composition and Biological Activity Analysis DOI Creative Commons
Ying Li, Renhua Huang, Weiwei Zhang

и другие.

Plants, Год журнала: 2025, Номер 14(4), С. 523 - 523

Опубликована: Фев. 8, 2025

Broussonetia papyrifera (L.) L'Hér. ex Vent., a dioecious tree species that belongs to the Moraceae family, is perennial plant found extensively throughout China. Its leaves are rich in essential trace elements such as copper, molybdenum, manganese, and iron, well various biologically active compounds, including amino acids, polysaccharides, proteins, flavonoids, phenylpropanoids, other polyphenolic compounds. These compounds exhibit significant pharmacological effects, antioxidant, lipid-lowering, heat-clearing, detoxifying, blood-cooling, diuretic, immunomodulatory activities. In recent years, B. has gained attention for its medicinal potential; however, breeding efforts, especially those aimed at increasing flavonoid content, have lagged. This study reviews progress research on ingredients of papyrifera, with focus identification methods, classification criteria, enrichment technologies components. The biosynthesis structural genes transcription factors flavonoids been investigated papyrifera. effects secondary metabolites were systematically examined, aiming offer strategies enhancing content promoting value.

Язык: Английский

Процитировано

1
Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities DOI Creative Commons

Yanmei Liao,

Fei Lv,

Tianwen Quan

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 24, 2024

The liver is the largest, important organ and site for essential biochemical reactions in human body. It has function to detoxify toxic substances synthesize useful biomolecules. Liver diseases related complications represent a significant source of morbidity mortality worldwide, creating substantial economic burden. Oxidative stress, excessive inflammation, dysregulated energy metabolism significantly contributed diseases. Therefore, discovery novel therapeutic drugs treatment are urgently required. For centuries, flavonoids their preparations which have beneficial health effects chronic been used treat various illnesses. Flavonoids mainly include flavones, isoflavones, flavanols, dihydroflavones, dihydroflavonols, anthocyanins chalcones. primary objective this review assess efficacy safety flavonoids, from clinical point view considering clinically relevant end-points. We summarized recent progress research hepatoprotective molecular mechanisms different bioactive ingredients also outlined networks underlying signaling pathways. Further pharmacology toxicology will contribute development natural products derivatives as medicines with alluring prospect application.

Язык: Английский

Процитировано

5
Clinical Insights into Non-Alcoholic Fatty Liver Disease and the Therapeutic Potential of Flavonoids: An Update DOI Open Access
Aleksandra Kozłowska

Nutrients, Год журнала: 2025, Номер 17(6), С. 956 - 956

Опубликована: Март 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is considered a significant global health issue related to serious metabolic disorders. However, effective pharmacological treatments are still limited. Flavonoids, wide group of polyphenol substances, exert anti-inflammatory and lipid-lowering effects in preclinical data. Thus, implementing these research findings clinical practice could significantly help manage NAFLD its consequences. This narrative review assesses the therapeutic potential flavonoids managing NAFLD. The collected randomized controlled trials (RCTs) meta-analyses RCTs from past five years concerning impact on A total 20 studies were selected according predetermined inclusion criteria, comprising thirteen seven meta-analyses. underscores beneficial management through enhancement lipid metabolism, reduction hepatic steatosis, provision actions. Clinical demonstrate that interventions rich flavonoids, including quercetin, epigallocatechin gallate, naringenin, isoflavones, substantially reduce fat content enhance enzyme profiles, with certain compounds exhibiting superior efficacy particular subgroups, such as older adults females. Nonetheless, whereas therapies diminish their effect fibrosis constrained. To sum up, exhibit supplementary for by enhancing function, inflammation. Additional extensive necessary create uniform treatment methods ascertain long-term advantages.

Язык: Английский

Процитировано

0
Differences in Fatty Acid Metabolism between MCDD and HFD Induced Metabolic Dysfunction-associated Fatty Liver Disease Model Mice DOI Creative Commons
Jiaxuan Wang, Xinzhu Liu, Zhen Guo

и другие.

Biological Procedures Online, Год журнала: 2025, Номер 27(1)

Опубликована: Апрель 14, 2025

The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing annually, which has become a major public-health concern. MAFLD typically associated with obesity, hyperlipemia, or syndrome. Dietary induction one the most common methods for preparing animal models MAFLD. However, there are phenotypic differences between methionine-choline-deficient diet (MCDD) and high fat (HFD) models. To explore in hepatic acid metabolism MCDD HFD induced MAFLD, we analyzed serum tissue from two We found that accumulation function damage were pathological features both Furthermore, model, expression transport proteins increased, while efflux mRNA decreased, along decrease blood lipid levels. In uptake proteins, an increase Impaired oxidation increased play key roles pathogenesis inverse changes de novo lipogenesis may represent important mechanism leads to

Язык: Английский

Процитировано

0
Copper homeostasis and cuproptosis‐related genes: Therapeutic perspectives in non‐alcoholic fatty liver disease DOI Creative Commons
Wangjing Tan, Junli Zhang, Li Chen

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(11), С. 4830 - 4845

Опубликована: Сен. 4, 2024

Non-alcoholic fatty liver disease (NAFLD), a metabolic-associated disease, has become the most common chronic worldwide. Recently, discovery of cuproptosis, newly identified mode cell death, further highlighted importance copper in maintaining metabolic homeostasis. An increasing number studies have confirmed that metabolism is closely related to pathogenesis NAFLD. However, relationship between NAFLD and metabolism, especially remains unclear. In this review, we aim summarize current understanding its dysregulation, particularly role dysregulation More importantly, review emphasizes potential gene-targeted therapeutic strategies, challenges future cuproptosis-related genes treatment This aims provide innovative strategies for

Язык: Английский

Процитировано

3
Cardio-Protective-Promoting Properties of Functional Foods Inducing HDL-Cholesterol Levels and Functionality DOI Creative Commons

Athina Velissaridou,

Ellie Panoutsopoulou,

Vasileios Prokopiou

и другие.

Nutraceuticals, Год журнала: 2024, Номер 4(4), С. 469 - 502

Опубликована: Сен. 30, 2024

High-density lipoprotein (HDL) has been proposed to provide cardio-protective properties through the functionality of its anti-inflammatory and antioxidant enzymatic machinery. Within this article, beneficial effects several functional foods on HDL levels for cardio-protection are thoroughly reviewed. Emphasis is given their health-promoting cardiovascular system benefits HDL, which act either solely or synergistically as an adjuvant approach with well-established anti-atherogenic therapies. Promising outcomes from both in vitro vivo studies animal models clinical trials, outline such functionality, discussed. The mechanisms obtained antioxidant, anti-inflammatory, antithrombotic, activities containing natural bioactives also outlined. Limitations future perspectives overall that these bioactive compounds exert important ingredients induce HDL-related strengthen health

Язык: Английский

Процитировано

3
Potential treatment of glutathione in bullfrogs with abnormal hepatic lipid metabolism revealed by hepatic lipid metabolism and serum metabolomics analysis DOI Creative Commons

Zehui Su,

Fu Gao, Rui Shu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Авг. 13, 2024

Introduction With the continuous growth of bullfrog supply, it has become an important aquaculture species. Due to lack actionable industry standards and regulation, misuse anti-disease drugs abnormal liver lipid metabolism in bullfrogs have a major obstacle development industry. Glutathione is natural tripeptide that can be synthesized intracellularly, its physiological functions mainly include treatment diseases, antioxidant, detoxification, anti-tumor, enhancement immunity, delaying aging. Methods In this study, therapeutic effect glutathione on with was revealed from hepatic serum metabolomics analysis. The survival rate, histomorphology, antioxidant enzyme activity, lipase activity metabolomics, were studied analyzed by feeding for 20 days NC, FI GSH groups. Results results study showed able repair improve rate metabolism; SOD enzymes significantly increased; activities ACP AKP decreased; HDL-C T-CHO LDL-C, TBA, TG decreased liver; contents metabolites, such as PC, PS, PE up-regulated, levels up-regulated Autophagy - other, Necroptosis ErbB signaling pathway, down-regulated Sphingolipid metabolism, D-Amino acid metabolic some extent pathways alleviate disorders glycerophospholipid amino certain extent, thus alleviating abnormalities metabolism. Discussion could effectively treat disorder bullfrogs, promote function, reduce inflammation, healthy green

Язык: Английский

Процитировано

1