Food & Function, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Administering ferulic acid and protocatechuic acid, which can activate brown fat thermogenesis, to ApoE −/− mice alleviate atherosclerosis.
Язык: Английский
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 11, 2025
The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on global scale. A substantial body evidence indicates that there is complex relationship between OP, with correlation the occurrence OP obesity. In recent years, sirtuins have emerged as prominent area interest in fields aging endocrine metabolism. Among various research avenues exploring potential sirtuins, effects these proteins garnered attention from numerous researchers. Sirtuins regulate energy balance lipid balance, which turn inhibit process adipogenesis. Additionally, osteogenic osteoblastic activity, protects against development OP. However, no study has yet provided comprehensive discussion three: obesity, This paper will therefore describe focusing possibility treating caused by targeting sirtuins. be based common influences (such mesenchymal stem cells, gut microbiota, insulin). Finally, SIRT1, an important member polyphenolic natural products for treatment presented. contribute to better understanding interactions bone, facilitate new therapeutic strategies future.
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2025, Номер 14(4), С. 492 - 492
Опубликована: Апрель 18, 2025
Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body introduced dietary sources smoking. Recent clinical animal studies have highlighted significant role various health conditions. These accumulate nearly all mammalian tissues associated with range diseases, including diabetes its complications, cardiovascular disease, neurodegeneration. This review summarizes major diseases linked to AGE accumulation, presenting both experimental evidence. The pathologies induced by share common mechanisms across different organs, primarily involving oxidative stress, chronic inflammation, direct protein cross-linking. Interventions targeting AGE-related focus on inhibiting formation using synthetic natural antioxidants, as well intake lifestyle modifications. recognized risk factors that impact accelerate aging, particularly individuals hyperglycemia. Monitoring level implementing nutritional interventions help maintain overall reduce complications.
Язык: Английский
Процитировано
1
Essays in Biochemistry, Год журнала: 2024, Номер 68(3), С. 349 - 361
Опубликована: Авг. 23, 2024
Abstract Obesity is a major risk factor for many life-threatening diseases. Adipose tissue dysfunction emerging as driving in the transition from excess adiposity to comorbidities such metabolic-associated fatty liver disease, cardiovascular Type 2 diabetes and cancer. However, healthy adipose expansion development of these conditions poorly understood. stem cells, residing vasculature stromal regions subcutaneous visceral depots, are responsible maintenance organ function, now recognised key mediators pathological transformation. Impaired drives inflammation, dysregulation endocrine function deposition lipids liver, muscle around vital organs, where it toxic. Contrary previous hypotheses, promotion not inhibition adipogenesis, that presents most attractive therapeutic strategy treatment metabolic disease. AMP-activated protein kinase, master regulator energy homeostasis, has been regarded one target, due its central role lipid metabolism, apparent adipogenesis. recent studies utilising kinase (AMPK)-specific compounds highlight more subtle, time-dependent AMPK process previously unexplored repression leptin, independent adipocyte maturity. In this article, I discuss historic evidence AMPK-mediated adipogenesis multi-faceted roles tissue.
Язык: Английский
Процитировано
4
Talanta, Год журнала: 2025, Номер 291, С. 127891 - 127891
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0
Pharmacological Research, Год журнала: 2025, Номер 216, С. 107744 - 107744
Опубликована: Апрель 21, 2025
The clinical continuum of heart failure (HF) is commonly divided into four stages (A, B, C and D), but despite the identification its staging, to date, management early phases remains an unmet need. In fact, incomplete knowledge molecular mechanisms associated with comorbidities leading HF onset represents obstacle a targeted therapy. Recently, A B have been further typified and, starting from this novel characterization, aim our review was propose alternative criterion appropriately use GLP-1 RA in association plant-derived polyphenolic extracts. This approach based on selection main underlying asymptomatic that might be prevented or antagonized through administration natural
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(9), С. 1933 - 1933
Опубликована: Апрель 26, 2025
The rising demand for alternative solutions to diabetes mellitus has prompted significant interest in the exploration of plant-derived anti-diabetic compounds, especially within a circular economy framework that seeks sustainable and profitable reuse options. In this context, red (RSGO) white (WGSO) grape seed oils, by-products Sicilian vineyards, were prepared, analyzed their fatty acid, polyphenol, carotenoid, chlorophyll content, evaluated glucose-lowering ability on HepG2 cells. Utilizing cytochemical techniques, flow cytometry, protein blotting, we explored effects non-toxic oil dilutions (i) glycogen storage, (ii) glucose consumption/uptake, (iii) GLUT-2, GLUT-4, hepatocyte nuclear factor-1α (HNF1α) expression levels, (iv) AMP-activated kinase (AMPK), insulin receptor substrate-1 (IRS-1), AKT, PKCζ phosphorylation states, which are involved insulin-mediated -independent regulation GLUT-4 membrane exposure. RGSO WGSO, despite adopting slightly varying molecular strategies, both proven be effective stimulators absorption glycogenesis. Specifically, RSGO promoted GLUT-2 up-regulation, whereas WGSO-induced effect was associated with an increase levels alone. Moreover, oils activated pathways responsible translocation. Therefore, these wine-making residues have substantial potential as solutions, holding promise integration into biomedical food sectors.
Язык: Английский
Процитировано
0
Food & Function, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Administering ferulic acid and protocatechuic acid, which can activate brown fat thermogenesis, to ApoE −/− mice alleviate atherosclerosis.
Язык: Английский
Процитировано
1