Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1848 - 1848

Опубликована: Фев. 3, 2024

Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year.

Язык: Английский

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H₂S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation

Advanced Science, Год журнала: 2024, Номер 11(14)

Опубликована: Фев. 2, 2024

Abstract Abnormal activation of the intestinal mucosal immune system, resulting from damage to barrier and extensive invasion by pathogens, contributes pathogenesis inflammatory bowel disease (IBD). Current first‐line treatments for IBD have limited efficacy significant side effects. An innovative H 2 S‐releasing montmorillonite nanoformulation (DPs@MMT) capable remodeling homeostasis, repairing barrier, modulating gut microbiota is developed electrostatically adsorbing diallyl trisulfide‐loaded peptide dendrimer nanogels (DATS@PDNs, abbreviated as DPs) onto (MMT) surface. Upon rectal administration, DPs@MMT specifically binds covers damaged mucosa, promoting accumulation subsequent internalization DPs activated cells in site. release S intracellularly response glutathione, initiating multiple therapeutic In vitro vivo studies shown that effectively alleviates colitis eliminating reactive oxygen species (ROS), inhibiting inflammation, eradicating pathogens. RNA sequencing revealed exerts immunoregulatory repair effects, activating pathways such Nrf2/HO‐1, PI3K‐AKT, RAS/MAPK/AP‐1, p38/ERK MAPK, p65 NF‐κB, JAK‐STAT3 pathways, well glycolysis. 16S rRNA demonstrated remodels pathogens increasing probiotics. This study develops a promising management.

Язык: Английский

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Natural products targeting the MAPK-signaling pathway in cancer: overview

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(1)

Опубликована: Янв. 1, 2024

Abstract Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these are elucidated, comprehensive information is provided on their potential use Methods Using PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant components”, “MAPK-signaling pathway”. We also screened compounds with well-defined structures targeting have effects. used Kingdraw software Adobe Photoshop to draw compound structural diagrams. Results A total 131 papers were searched, from which 85 selected. These clear treatment mainly related pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, juglone. components classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, quinones. Conclusions Certain MAPK inhibitors been clinical treatment. However, feedback has not promising because genomic instability, drug resistance, side Natural few effects, good medicinal efficacy, a wide range sources, individual heterogeneity biological activity, capable treating disease multiple targets. characteristics make drugs

Язык: Английский

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A network pharmacology approach and experimental validation to investigate the anticancer mechanism of Qi-Qin-Hu-Chang formula against colitis-associated colorectal cancer through induction of apoptosis via JNK/p38 MAPK signaling pathway

Journal of Ethnopharmacology, Год журнала: 2023, Номер 319, С. 117323 - 117323

Опубликована: Окт. 16, 2023

The Qi-Qin-Hu-Chang Formula (QQHCF) is a traditional Chinese medicine prescription that clinically used at the Affiliated Hospital of Nanjing University Medicine for treatment colitis-associated colorectal cancer (CAC).

Язык: Английский

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Beta-elemene: A phytochemical with promise as a drug candidate for tumor therapy and adjuvant tumor therapy

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116266 - 116266

Опубликована: Фев. 13, 2024

β-Elemene (IUPAC name: (1 S,2 S,4 R)-1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl) cyclohexane), is a natural compound found in turmeric root. Studies have demonstrated its diverse biological functions, including anti-tumor properties, which been extensively investigated. However, these not yet reviewed. The aim of this review was to provide comprehensive summary β-elemene research, with respect disease treatment.

Язык: Английский

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Combination of bulk RNA sequencing and scRNA sequencing uncover the molecular characteristics of MAPK signaling in kidney renal clear cell carcinoma

Aging, Год журнала: 2024, Номер 16(2), С. 1414 - 1439

Опубликована: Янв. 12, 2024

The MAPK signaling pathway significantly impacts cancer progression and resistance; however, its functions remain incompletely assessed across various cancers, particularly in kidney renal clear cell carcinoma (KIRC). Therefore, there is an urgent need for comprehensive pan-cancer investigations of signaling, within the context KIRC. In this research, we obtained TCGA multi-omics data conducted a analysis genomic transcriptomic characteristics pathway. For in-depth investigation KIRC, status was quantitatively estimated by ssGSEA Ward algorithm utilized cluster analysis. Molecular clinical prognoses KIRC patients with distinct activities were comprehensively explored using series bioinformatics algorithms. Subsequently, combination LASSO COX regression analyses sequentially to construct MAPK-related signature help identify risk level each sample. Patients C1 subtype exhibited relatively higher levels activity, which associated abundant immune infiltration favorable outcomes. Single-cell RNA sequencing (scRNA-seq) samples identified seven types, endothelial cells tumor tissues had obviously scores than normal tissues. immunohistochemistry results indicated reduced expression PAPSS1, MAP3K11, SPRED1 samples. conclusion, our study represents first integration bulk single-cell elucidate molecular providing solid foundation precision oncology.

Язык: Английский

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Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways

Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)

Опубликована: Апрель 23, 2024

Abstract The interaction between programmed cell death ligand 1 (PD-L1), which is expressed on the surface of tumor cells, and (PD-1), T impedes effective activation antigen-specific resulting in evasion cells from immune-mediated killing. Blocking PD-1/PD-L1 signaling pathway has been shown to be preventing immune evasion. blocking antibodies have garnered significant attention recent years within field treatments, given aforementioned mechanism. Furthermore, clinical research substantiated efficacy safety this immunotherapy across various tumors, offering renewed optimism for patients. However, challenges persist anti-PD-1/PD-L1 therapies, marked by limited indications emergence drug resistance. Consequently, identifying additional regulatory pathways molecules associated with implementing judicious combined treatments are imperative addressing intricacies mechanisms. This review briefly outlines structure molecule, emphasizing posttranslational modification mechanisms related targets. Additionally, a comprehensive overview landscape concerning post-translational modifications enhance outcomes broader spectrum patients presented based foundational research.

Язык: Английский

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Synergistic Inhibition of Breast Carcinoma Cell Proliferation by Quercetin and Sulforaphane via Activation of the ERK/MAPK Pathway

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

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Cadmium exposure induces inflammation, oxidative stress and DNA damage in HUVEC and promotes THP-1 adhesion: a possible mechanism on the formation of Atherosclerotic plaque

Toxicology, Год журнала: 2025, Номер unknown, С. 154046 - 154046

Опубликована: Янв. 1, 2025

Язык: Английский

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Deubiquitinase Ubiquitin‐Specific Protease 29 Ameliorates Pathological Cardiac Hypertrophy through Inhibiting Transforming Growth Factor β‐Activated Kinase 1

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Pathological cardiac hypertrophy, characterized by the involvement of multiple regulators, ultimately leads to heart failure in absence effective interventions. The identification key factors involved is crucial for exploring novel treatments failure. However, function and pathological implications USP29 (ubiquitin-specific protease 29) cardiomyocytes remain unknown. impacts on hypertrophy were investigated through use knockout/overexpression mice overexpression/knockdown cardiomyocytes, accompanied bioinformatic analysis molecular biological techniques elucidate underlying mechanisms. We observed upregulation protein levels both transverse aortic constriction-induced hypertrophic hearts (upregulated 159.8%) phenylephrine-induced 184.6%). Moreover, genetic knockout exacerbated dysfunction, fibrosis, whereas overexpression using adeno-associated virus 9 effectively attenuated response. Similarly, alleviated primary neonatal rat cardiomyocytes. Mechanistically, cardioprotective effects mediated attributed its suppression TAK1 (transforming growth factor β-activated kinase 1) activation. Further revealed that directly interacts with amino acids 284 922 1 306 TAK1, subsequently inhibiting activation via K63-linked deubiquitination, which indispensable regulating USP29. Here, we have identified as a negative regulator hypertrophy. Our findings suggest targeting either or interaction could represent an innovative therapeutic strategy treating

Язык: Английский

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