Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

---

Stimulator of Interferon Genes-Activated Biomimetic Dendritic Cell Nanovaccine as a Chemotherapeutic Booster to Enhance Systemic Fibrosarcoma Treatment

ACS Nano, Год журнала: 2024, Номер 18(35), С. 24219 - 24235

Опубликована: Авг. 22, 2024

Fibrosarcoma, a malignant mesenchymal tumor, is characterized by aggressive invasiveness and high recurrence rate, leading to poor prognosis. Anthracycline drugs, such as doxorubicin (DOX), represent the frontline chemotherapy for fibrosarcoma, but often exhibit suboptimal efficacy. Recently, exploiting stimulator of interferon genes (STING)-mediated innate immunity has emerged hopeful strategy cancer treatment. Integrating with immunomodulators in chemo-immunotherapy shown potential enhancing treatment outcomes. Herein, we introduce an advanced dendritic cell (DC) nanovaccine, cGAMP@PLGA@CRTM (GP@CRTM), combined low-dose DOX enhance fibrosarcoma chemo-immunotherapy. The nanovaccine consists poly(lactic-

Язык: Английский

---

Immunostimulatory effects of thermal ablation: Challenges and future prospects

Journal of Cancer Research and Therapeutics, Год журнала: 2024, Номер 20(2), С. 531 - 539

Опубликована: Апрель 1, 2024

ABSTRACT This literature explores the immunostimulatory effects of thermal ablation in tumor microenvironment, elucidating mechanisms such as immunogenic cell death, tumor-specific antigens, and damage-associated molecular patterns. Furthermore, it outlines critical issues associated with ablation-induced challenges offers insights into future research avenues potential therapeutic strategies.

Язык: Английский

---

Developing a Rhodium(III) Complex to Reprogram the Tumor Immune and Metabolic Microenvironments: Overcoming Multidrug Resistance and Metastasis in Non-Small Cell Lung Cancer

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(19), С. 17243 - 17258

Опубликована: Сен. 19, 2024

To effectively inhibit the growth and metastasis of non-small cell lung cancer (NSCLC) overcome its multidrug resistance (MDR), we designed synthesized a series rhodium (Rh, III) 2-benzoylpyridine thiosemicarbazone complexes. Through studying their structure-activity relationships, identified Rh(III) complex (Rh4) with excellent cytotoxicity against multidrug-resistant cells (A549/ADR cells). Additionally, successfully constructed an apoferritin (AFt) nanoparticle (NP) delivery system (AFt-Rh4 NPs). Importantly, AFt-Rh4 NPs not only exhibited antitumor antimetastatic capabilities NSCLC

Язык: Английский

---

Ruthenium(Ii) Polypyridyl Complexes Inhibit Tumor Growth Through Stimulating Immune System to Increase Cd8+ T Cell

Опубликована: Янв. 1, 2025

In this work, we have carefully designed and synthesized two Ru(II) metal complexes: [Ru(phen)2(HMPIP)](PF6)2 (6a, where phen = 1,10-phenanthroline, HMPIP 2-(2-hydroxy-3-methylphenyl-1H-imidazo[4,5-f][1,10]phenanthroline) [Ru(bpy)2(HMPIP)](PF6)2 (6b, bpy 2,2'-bipyridine). Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to explore the cytotoxicity of 6a 6b towards HepG2, B16, A549, SGC-7901, HCT116 non-cancer LO2. The complexes exhibited activity against HepG2 cells. capacity impede proliferation dissemination cancer cells was evaluated by conducting migration experiments 3D model. anticancer mechanism investigated in detail. utilization cycle blocking assays revealed that induced a G0/G1 phase arrest Apoptosis examination proteins indicated were capable efficiently inducing apoptosis Additionally, potential induction autophagy-mediated cell death explored. observed reduction glutathione (GSH) levels peroxidase 4 (GPX4) expression suggested disruption redox homeostasis within cells, an increment malondialdehyde (MDA) amount, together with BODIPY staining experiment, confirm can induce ferroptosis. Interestingly, nude mouse model, showed significant suppression tumor growth inhibition rate 63.4%, without causing any weight loss mice. studies on show causes immune death, increase amount TNF-α IFN-γ, reduce IL-10 content, which further activates response CD8+ T prevent growth. Therefore, inhibits through stimulating These results demonstrate may be potent candidates for tumor.

Язык: Английский

---

Ruthenium(II) Polypyridyl Complexes Inhibit Tumor Growth Through Stimulating Immune System to Increase CD8+ T Cell

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 289, С. 117470 - 117470

Опубликована: Фев. 28, 2025

Язык: Английский

---

Hydrogel Delivering All‐Trans Retinoic Acid to Regulate Macrophage Polarization to Enhance Chemo‐Immunotherapy for Gastric Cancer

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract As Gastric cancer is one of the most common gastrointestinal malignancies in China, with a 5‐year relative survival rate ≈40%. Therefore, development new strategies to treat gastric becomes urgent. In recent years, an increasing number studies have found that all‐trans retinoic acid (Tre) can induce polarization M2 macrophages toward M1 tumor immune microenvironment (TIME), and therefore play due role this treatment. This research proposes load doxorubicin (DOX) Tre mesoporous silica, which then loaded into sodium alginate slow‐release Gel obtain final product (GEL‐MSDT). Gel‐MSDT sustained‐release hydrogel release DOX locally tumor, kill cells, immunogenic death, regulate tumor‐associated macrophage phenotype, promote anti‐tumor response. coordinate chemotherapy immunotherapy, delay lasting effect. The results vitro vivo experiments show significantly inhibit growth, providing effective strategy for treatment cancer.

Язык: Английский

---

Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies

Biomedicines, Год журнала: 2025, Номер 13(4), С. 950 - 950

Опубликована: Апрель 12, 2025

Immunogenic cell death (ICD) is a promising cancer therapy where dying tumor cells release damage-associated molecular patterns (DAMPs) to activate immune responses. Recent research highlights the critical role of metabolic reprogramming in cells, including Warburg effect, oxidative stress, and lipid metabolism, modulating ICD shaping microenvironment. These changes enhance activation, making tumors more susceptible surveillance. This review explores mechanisms linking mitochondrial endoplasmic reticulum (ER) ferroptosis. It also discusses innovative therapeutic strategies, such as personalized combination therapies, inhibitors, targeted delivery systems, improve efficacy. The future immunotherapy lies integrating activation overcome evasion, with multi-omics approaches microbiome modulation offering new avenues for enhanced treatment outcomes.

Язык: Английский

---

Heating Tumors with Tumor Cell-Derived Nanoparticles to Enhance Chemoimmunotherapy for Colorectal Cancer

Nanomedicine, Год журнала: 2024, Номер 19(7), С. 561 - 579

Опубликована: Янв. 24, 2024

Aim: To investigate the mechanism of doxorubicin (DOX)-induced immunogenic cell death (ICD) and to improve immunotherapy efficacy. Materials & methods: In this study, hybrid vesicles containing DOX (HV-DOX) were prepared by thin-film hydration with extrusion, formulated nanoparticles characterized physically. Furthermore, in vitro experiments animal models used efficacy new mechanisms chemotherapy combined immunotherapy. Results: improved tumor immunogenicity alkalinizing lysosomes, inhibiting autophagy inducing ICD. HVs could activate dendritic maturation, synergistically enhancing chemotherapeutic immunity. Conclusion: The DOX-induced ICD was explored, antitumor immunity activated HV-DOX drug loading provide relevant antigenic information.

Язык: Английский

---