Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 10, 2024
The
differentiation
of
vascular
endothelial
cells
and
the
formation
new
blood
vessels
are
inseparable
from
energy
supply
regulation
metabolism.
budding
is
a
starting
point
glycolysis
pathway
in
angiogenesis.
Phosphofructokinase-2/fructose
2,6-biophosphatase
3
(PFKFB3),
key
rate-limiting
enzyme
glycolysis,
exhibits
strong
kinase
activity.
Inhibition
PFKFB3
can
reduce
rate
thereby
inhibiting
vessels,
resulting
inhibition
pathological
In
this
review,
role
angiogenesis
inflammatory
diseases
was
summarized,
associated
with
were
reviewed.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 11, 2025
Abstract
Accumulated
evidence
has
implicated
the
diverse
and
substantial
influence
of
lactate
on
cellular
differentiation
fate
regulation
in
physiological
pathological
settings,
particularly
intricate
conditions
such
as
cancer.
Specifically,
been
demonstrated
to
be
pivotal
molding
tumor
microenvironment
(TME)
through
its
effects
different
cell
populations.
Within
cells,
impacts
signaling
pathways,
augments
shuttle
process,
boosts
resistance
oxidative
stress,
contributes
lactylation.
In
various
populations,
interplay
between
immune
cells
governs
processes
differentiation,
response,
surveillance,
treatment
effectiveness.
Furthermore,
communication
stromal/endothelial
supports
basal
membrane
(BM)
remodeling,
epithelial-mesenchymal
transitions
(EMT),
metabolic
reprogramming,
angiogenesis,
drug
resistance.
Focusing
production
transport,
specifically
dehydrogenase
(LDH)
monocarboxylate
transporters
(MCT),
shown
promise
Inhibitors
targeting
LDH
MCT
act
both
suppressors
enhancers
immunotherapy,
leading
a
synergistic
therapeutic
effect
when
combined
with
immunotherapy.
The
review
underscores
importance
progression
provides
valuable
perspectives
potential
approaches
that
target
vulnerability
metabolism,
highlighting
Heel
Achilles
for
cancer
treatment.
The
rising
trend
in
global
cancer
incidence
has
caused
widespread
concern,
one
of
the
main
reasons
being
aging
population.
Statistical
data
show
that
and
mortality
rates
a
clear
upward
with
age.
Although
there
is
commonality
between
dysregulated
nutrient
sensing,
which
features
aging,
metabolic
reprogramming
tumor
cells,
specific
regulatory
relationship
not
clear.
This
manuscript
intends
to
comprehensively
analyze
senescence
reprogramming;
as
well
reveal
impact
key
factors
leading
cellular
on
tumorigenesis.
In
addition,
this
review
summarizes
current
intervention
strategies
targeting
sensing
pathways,
clinical
cases
treating
tumors
characteristics
existing
nanodelivery
research
strategies.
Finally,
it
also
suggests
sensible
dietary
habits
for
those
who
wish
combat
aging.
conclusion,
attempts
sort
out
link
metabolism
provide
new
ideas
treatment.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 423 - 423
Опубликована: Март 29, 2024
Diabetic
retinopathy
(DR)
is
the
leading
cause
of
visual
impairment
and
blindness
among
working-age
population.
Microglia,
resident
immune
cells
in
retina,
are
recognized
as
crucial
drivers
DR
process.
Microglia
activation
a
tightly
regulated
immunometabolic
In
early
stages
DR,
M1
phenotype
commonly
shifts
from
oxidative
phosphorylation
to
aerobic
glycolysis
for
energy
production.
Emerging
evidence
suggests
that
microglia
not
only
engage
specific
metabolic
pathways
but
also
rearrange
their
oxidation-reduction
(redox)
system.
This
redox
adaptation
supports
reprogramming
offers
potential
therapeutic
strategies
using
antioxidants.
Here,
we
provide
an
overview
recent
insights
into
involvement
reactive
oxygen
species
distinct
roles
played
by
key
cellular
antioxidant
pathways,
including
NADPH
oxidase
2
system,
which
promotes
via
enhanced
glucose
transporter
4
translocation
cell
membrane
through
AKT/mTOR
pathway,
well
thioredoxin
nuclear
factor
E2-related
systems,
maintain
anti-inflammatory
state.
Therefore,
highlight
targeting
modulation
microglial
metabolism
offer
new
concepts
treatment.
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
267, С. 116209 - 116209
Опубликована: Фев. 2, 2024
Our
previous
research
has
revealed
phosphoglycerate
kinase
1
(PGK1)
enhances
tumorigenesis
and
sorafenib
resistance
of
kidney
renal
clear
cell
carcinoma
(KIRC)
by
regulating
glycolysis,
so
that
PGK1
is
a
promising
drug
target.
Herein
we
performed
structure-based
virtual
screening
series
anticancer
pharmaceutical
experiments
in
vitro
vivo
to
identify
novel
small-molecule
PGK1-targeted
compounds.
As
results,
the
compounds
CHR-6494
Z57346765
were
screened
confirmed
specifically
bind
significantly
reduced
metabolic
enzyme
activity
which
inhibited
KIRC
proliferation
dose-dependent
manner.
While
showed
greater
anti-KIRC
efficacy
fewer
side
effects
than
on
nude
mouse
xenograft
model.
Mechanistically,
CHR-9464
impeded
glycolysis
decreasing
suppressed
histone
H3T3
phosphorylation
inhibit
proliferation.
induced
expression
changes
genes
related
metabolism,
DNA
replication
cycle.
Overall,
two
inhibitors,
Z57346765,
for
first
time
discovered
their
potent
suppressing
glycolysis.
Cancer Biology & Therapy,
Год журнала:
2025,
Номер
26(1)
Опубликована: Май 14, 2025
This
study
aims
to
explore
the
effects
of
silencing
Zic
family
member
5
(ZIC5)
on
glucose
metabolism
and
disulfidptosis
in
lung
adenocarcinoma
(LUAD)
cells.
Data
from
The
Cancer
Genome
Atlas
(TCGA)
was
used
analyze
ZIC5
expression
LUAD
its
association
with
patient
outcomes.
silenced
A549
H1299
cells
using
siRNA.
mRNA
protein
assessed
by
qRT-PCR
Western
blot.
Cell
proliferation
evaluated
through
CCK-8
5-ethynyl-2'-deoxyuridine
(EdU)
assays,
while
uptake,
lactate
production,
ATP
levels
were
measured
assess
energy
metabolism.
Seahorse
XF
analysis
evaluate
extracellular
acidification
rate
(ECAR)
oxygen
consumption
(OCR).
Disulfidptosis
NADP+/NADPH
ratio,
glutathione
(GSH)
content,
GSSG/GSH
immunofluorescence
staining.
is
highly
expressed
associated
poor
prognosis.
Silencing
significantly
reduced
cells,
markedly
inhibited
cell
proliferation,
led
significant
decreases
levels,
ECAR,
OCR.
Additionally,
resulted
an
increased
decreased
GSH
a
alongside
classic
features.
plays
crucial
role
promoting
inhibiting
disulfidptosis.
suppresses
these
processes,
indicating
potential
as
therapeutic
target
LUAD.
International Journal of Oncology,
Год журнала:
2024,
Номер
64(4)
Опубликована: Март 1, 2024
Among
all
types
of
renal
cancer,
clear
cell
carcinoma
(ccRCC)
is
the
most
common
and
lethal
subtype
associated
with
a
high
risk
metastasis
recurrence.
Histone
modifications
regulate
several
biological
processes
that
are
fundamental
to
development
cancer.
Lysine
methyltransferase
5C
(KMT5C;
also
known
as
SUV420H2)
an
epigenetic
modifier
responsible
for
trimethylation
H4K20,
which
drives
critical
cellular
events,
including
genome
integrity,
growth
epithelial‑mesenchymal
transition
(EMT),
in
various
However,
role
KMT5C
ccRCC
remains
unclear.
As
such,
expression
function
were
investigated
present
study.
was
significantly
increased
tissues
compared
normal
(P<0.0001),
it
closely
overall
survival
rate
patients
ccRCC.
By
establishing
lines
knockdown,
maintenance
aerobic
glycolysis
cells
via
regulation
vital
glycolytic
genes
identified.
Additionally,
promoted
proliferation
EMT
by
controlling
crucial
transcriptional
factors.
Together,
these
data
suggested
may
act
oncoprotein,
guide
molecular
diagnosis,
shed
light
on
novel
drug
therapeutic
strategies
