Strategies to Target Chemoradiotherapy Resistance in Small Cell Lung Cancer DOI Open Access
Tony Yu, Benjamin H. Lok

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3438 - 3438

Published: Oct. 10, 2024

Small cell lung cancer (SCLC) is a lethal form of with few treatment options and high rate relapse. While SCLC initially sensitive to first-line DNA-damaging chemo- radiotherapy, relapse disease almost universally therapy-resistant. As result, there has been interest in understanding the mechanisms therapeutic resistance this disease.

Language: Английский

Lactate and lactylation in cancer DOI Creative Commons
Jie Chen, Ziyue Huang,

Ya Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 11, 2025

Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.

Language: Английский

Citations

9
Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells DOI

Sama W.A. Helmy,

Amal Kamal Abdel‐Aziz, Eman M.E. Dokla

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 268, P. 116255 - 116255

Published: Feb. 17, 2024

Language: Английский

Citations

7
Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo DOI Creative Commons
Yu He,

Yinheng Luo,

Lan Huang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 267, P. 116209 - 116209

Published: Feb. 2, 2024

Our previous research has revealed phosphoglycerate kinase 1 (PGK1) enhances tumorigenesis and sorafenib resistance of kidney renal clear cell carcinoma (KIRC) by regulating glycolysis, so that PGK1 is a promising drug target. Herein we performed structure-based virtual screening series anticancer pharmaceutical experiments in vitro vivo to identify novel small-molecule PGK1-targeted compounds. As results, the compounds CHR-6494 Z57346765 were screened confirmed specifically bind significantly reduced metabolic enzyme activity which inhibited KIRC proliferation dose-dependent manner. While showed greater anti-KIRC efficacy fewer side effects than on nude mouse xenograft model. Mechanistically, CHR-9464 impeded glycolysis decreasing suppressed histone H3T3 phosphorylation inhibit proliferation. induced expression changes genes related metabolism, DNA replication cycle. Overall, two inhibitors, Z57346765, for first time discovered their potent suppressing glycolysis.

Language: Английский

Citations

5
PLA inhibits TNF-α-induced PANoptosis of prostate cancer cells through metabolic reprogramming DOI
Yinghui Hao, Fangmei Xie,

Jieyi He

et al.

The International Journal of Biochemistry & Cell Biology, Journal Year: 2024, Volume and Issue: 169, P. 106554 - 106554

Published: Feb. 24, 2024

Language: Английский

Citations

4
Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy DOI Creative Commons
Luwei Cai, Mengxue Xia, Fang Zhang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 423 - 423

Published: March 29, 2024

Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness among working-age population. Microglia, resident immune cells in retina, are recognized as crucial drivers DR process. Microglia activation a tightly regulated immunometabolic In early stages DR, M1 phenotype commonly shifts from oxidative phosphorylation to aerobic glycolysis for energy production. Emerging evidence suggests that microglia not only engage specific metabolic pathways but also rearrange their oxidation-reduction (redox) system. This redox adaptation supports reprogramming offers potential therapeutic strategies using antioxidants. Here, we provide an overview recent insights into involvement reactive oxygen species distinct roles played by key cellular antioxidant pathways, including NADPH oxidase 2 system, which promotes via enhanced glucose transporter 4 translocation cell membrane through AKT/mTOR pathway, well thioredoxin nuclear factor E2-related systems, maintain anti-inflammatory state. Therefore, highlight targeting modulation microglial metabolism offer new concepts treatment.

Language: Английский

Citations

4
Regulation of Glycolysis by SMAD5 in Glioma Cells: Implications for Tumor Growth and Apoptosis DOI
Shiyang Zhang, Yizheng Wang,

Boyu Sun

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Decoding Osteosarcoma’s Lactylation Gene Expression: Insights Into Prognosis, Immune Dynamics, and Treatment DOI Creative Commons
Cheng Peng, Chaoqun You,

Shuang Cao

et al.

Analytical Cellular Pathology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unveiling Novel Targets in Lung Tumors for Enhanced Radiotherapy Efficacy: A Comprehensive Review DOI Open Access

Faris Anad Muhammad,

Ayat Hussein Adhab,

Morug Salih Mahdi

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 23, 2025

ABSTRACT Radiotherapy is a cornerstone of lung cancer management, though its efficacy frequently undermined by intrinsic and acquired radioresistance. This review examines the complexity tumors, highlighting their potential as reservoir novel targets for radiosensitization. Ionizing radiation (IR) primarily exerts effects through oxidative damage DNA double‐strand breaks (DSBs). Lung cells, however, develop mutations that enhance response (DDR) suppress cell death pathways. Additionally, interactions between tumor cells microenvironment (TME) components—including immune stromal molecular mediators such cytokines, chemokines, growth factors—contribute to resistance against IR. Understanding these intricate relationships reveals improve radiotherapy outcomes. Promising include DDR pathways, immunosuppressive molecules, hypoxia, proangiogenic mediators, other key signaling discusses emerging strategies, combining with immunomodulators, hypoxia inhibitors, DDR‐targeting agents, innovative approaches. By offering comprehensive analysis TME, this underscores opportunities effectiveness targeted radiosensitization strategies.

Language: Английский

Citations

0
Metabolic reprogramming in cancer and senescence DOI Creative Commons
Yuzhu Zhang, J. Tang, Can Jiang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being aging population. Statistical data show that and mortality rates a clear upward with age. Although there is commonality between dysregulated nutrient sensing, which features aging, metabolic reprogramming tumor cells, specific regulatory relationship not clear. This manuscript intends to comprehensively analyze senescence reprogramming; as well reveal impact key factors leading cellular on tumorigenesis. In addition, this review summarizes current intervention strategies targeting sensing pathways, clinical cases treating tumors characteristics existing nanodelivery research strategies. Finally, it also suggests sensible dietary habits for those who wish combat aging. conclusion, attempts sort out link metabolism provide new ideas treatment.

Language: Английский

Citations

0
Histone lactylation facilitates MCM7 expression to maintain stemness and radio-resistance in hepatocellular carcinoma DOI
Zijian Liu, Jiaqi Han, Shitong Su

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 236, P. 116887 - 116887

Published: March 20, 2025

Language: Английский

Citations

0