Stress, epigenetics, and aging: Unraveling the intricate crosstalk

Molecular Cell, Год журнала: 2023, Номер 84(1), С. 34 - 54

Опубликована: Ноя. 13, 2023

Язык: Английский

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Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging

Psychoneuroendocrinology, Год журнала: 2023, Номер 155, С. 106322 - 106322

Опубликована: Июнь 15, 2023

Stress triggers anticipatory physiological responses that promote survival, a phenomenon termed allostasis. However, the chronic activation of energy-dependent allostatic results in load, dysregulated state predicts functional decline, accelerates aging, and increases mortality humans. The energetic cost cellular basis for damaging effects load have not been defined. Here, by longitudinally profiling three unrelated primary human fibroblast lines across their lifespan, we find glucocorticoid exposure energy expenditure ~60%, along with metabolic shift from glycolysis to mitochondrial oxidative phosphorylation (OxPhos). This stress-induced hypermetabolism is linked mtDNA instability, non-linearly affects age-related cytokines secretion, aging based on DNA methylation clocks, telomere shortening rate, reduced lifespan. Pharmacologically normalizing OxPhos activity while further increasing exacerbates accelerated phenotype, pointing total as potential driver dynamics. Together, our findings define bioenergetic multi-omic recalibrations stress adaptation, underscoring increased interrelated features load.

Язык: Английский

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The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 153, С. 105359 - 105359

Опубликована: Авг. 15, 2023

Язык: Английский

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Food insecurity, poor diet, and metabolic measures: The roles of stress and cortisol

Appetite, Год журнала: 2024, Номер 197, С. 107294 - 107294

Опубликована: Март 11, 2024

Food insecurity is highly prevalent and linked to poorer diet worse metabolic outcomes. can be stressful, could elicit chronic psychological physiological stress. In this study, we tested whether stress used identify those at highest risk for measures from food insecurity. Specifically, hypothesized that cortisol (a marker of stress) perceived would amplify the link between hyperpalatable intake as well measures. a sample 624 Black White women aged 36–43 who participated in NHLBI Growth Health Study's midlife assessment, assessed associations with (high fat + high sodium foods; sugar carbohydrate foods), (fasting glucose, insulin resistance, waist circumference). We found was associated higher levels (R2 = 0.09), greater (hyperpalatable) foods 0.03). cumulative (as indexed by hair cortisol), fasting glucose. Neither nor moderated any other relationships, neither variable functioned mediator sensitivity analyses. Given these largely null findings, further research needed understand role plays health burdens

Язык: Английский

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Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study

Cancer, Год журнала: 2023, Номер 129(17), С. 2741 - 2753

Опубликована: Июнь 1, 2023

Abstract Background Cancer and its treatments may accelerate aging in survivors; however, research has not examined epigenetic markers of longer term breast cancer survivors. This study whether older survivors showed greater than noncancer controls related to functional outcomes. Methods Nonmetastatic ( n = 89) enrolled prior systemic therapy frequency‐matched 101) ages 62 84 years provided two blood samples derive measures (Horvath, Extrinsic Epigenetic Age [EEA], PhenoAge, GrimAge, Dunedin Pace Aging) completed cognitive (Functional Assessment Therapy‐Cognitive Function) physical (Medical Outcomes Study Short Form‐12) function assessments at approximately 24 36 60 months after enrollment. Mixed‐effects models tested survivor‐control differences aging, adjusting for age comorbidities; outcomes also adjusted racial group, site, reserve. Results Survivors were 1.04 2.22 biologically on Horvath, EEA, DunedinPACE p .001–.04) exposed chemotherapy 1.97 2.71 .001–.04), among this an EEA worse self‐reported cognition .047) relative controls. An all women < .001–.01). similar over time, but Black accelerated time non‐Hispanic White Conclusion Older survivors, particularly those chemotherapy, that relate If replicated, measurement biological could complement geriatric guide care women.

Язык: Английский

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To promote healthy aging, focus on the environment

Nature Aging, Год журнала: 2023, Номер 3(11), С. 1334 - 1344

Опубликована: Ноя. 9, 2023

Язык: Английский

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Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity

Cells, Год журнала: 2023, Номер 12(6), С. 957 - 957

Опубликована: Март 21, 2023

Brain vascular health appears to be critical for preventing the development of amyotrophic lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate cardiovascular risk factors commonly suffer from cerebrovascular disease, with evidence pathological alterations in their small cerebral blood vessels. Impaired brain has detrimental effects on motor neurons: endothelial growth factor levels are lowered ALS, which can compromise cell formation integrity blood–brain barrier. Increased turnover neurovascular unit cells precedes senescence, which, together pericyte alterations, further fosters failure toxic metabolite removal. We here provide a comprehensive overview pathogenesis impaired how novel magnetic resonance imaging techniques aid detection. In particular, we discuss patterns supply cortex number branches anterior middle arteries acting as marker resistance resilience against downstream events ALS. outline certain interventions adapted patient needs capabilities have potential mechanistically target microvasculature towards favorable patterns. Through this strategy, aim guide approaches management better understanding pathophysiology.

Язык: Английский

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The brain–body energy conservation model of aging

Nature Aging, Год журнала: 2024, Номер 4(10), С. 1354 - 1371

Опубликована: Окт. 8, 2024

Язык: Английский

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Exploring the interplay of psychological and biological components of stress response and telomere length in the transition from middle age to late adulthood: A systematic review

Stress and Health, Год журнала: 2024, Номер 40(4)

Опубликована: Март 5, 2024

Abstract Ageing and chronic stress have been linked to reduced telomere length (TL) in mixed‐age groups. Whether response components are TL during the midlife‐to‐late adulthood transition remains unclear. Our study aimed synthesise evidence on relationship between psychological biological of middle‐aged older adults. We conducted a systematic review studies obtained from six databases (PubMed, CINAHL, EMBASE, PsycINFO, Web Science, Scopus) evaluated by two independent reviewers. Original research measuring human individuals were included. From an initial pool 614 studies, 15 included ( n = 9446 participants). Synthesis showed that higher (i.e., global perceived or within specific life domain cognitive appraisal social‐evaluative stressors) shorter TL, specifically women under major stressors. For response, cortisol, dehydroepiandrosterone sulphate IGF‐1/cortisol imbalance, IL‐6, MCP‐1, blood pressure, heart rate presented significant association with but this depended stressors context (manipulated vs. non‐manipulated conditions). This comprehensive mainly those stressor stress‐induced conditions. The interaction attributes reactions middle late still needs be fully understood, examining it is critical step expanding our understanding stress's impact ageing trajectories.

Язык: Английский

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Social relationships and epigenetic aging in older adulthood: Results from the Health and Retirement Study

Brain Behavior and Immunity, Год журнала: 2023, Номер 114, С. 349 - 359

Опубликована: Сен. 7, 2023

Язык: Английский

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