Dermatological patients with itch report more stress, stigmatization experience, anxiety and depression compared to patients without itch: Results from a European multi‐centre study

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер 38(8), С. 1649 - 1661

Опубликована: Март 12, 2024

Abstract Background Itch as the most common symptom in dermatology has been shown to be related psychological factors such stress, anxiety and depression. Moreover, associations were found between perceived stigmatization itch. However, studies investigating differences patients with dermatoses without itch regarding stigmatization, depression are missing. Therefore, one of aims second study European Society for Dermatology Psychiatry (ESDaP II) was investigate these relationships a large cohort different itchy dermatoses. Results 3399 14 recruited at 22 centres 17 countries. They filled questionnaires assess signs clinically relevant or depression, itch‐related quality life, overall health status, duration, frequency intensity. The significant association severity itching perception stress observed among individuals rosacea (correlation coefficient r = 0.314). Similarly, strongest links intensity experiences anxiety, seborrheic dermatitis coefficients 0.317, 0.356, 0.400, respectively). Utilizing stepwise linear regression analysis, it determined that within entire patient cohort, 9.3% variation could accounted by including gender, levels stigmatization. Females elevated scores reported more pronounced intensities compared those contrary attributes. Conclusion This underscores connection experiencing its strain places on individuals. Consequently, interventions should encompass both addressing itself interconnected factors. In specific cases, becomes imperative dermatologists direct towards suitable healthcare resources undergo further assessment.

Язык: Английский

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T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities

Journal of Autoimmunity, Год журнала: 2024, Номер 144, С. 103176 - 103176

Опубликована: Фев. 15, 2024

Язык: Английский

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Polyphenol encapsulated nanofibers in wound healing and drug delivery

European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер 12, С. 100184 - 100184

Опубликована: Июнь 26, 2024

Polyphenol is a versatile green phytochemical vital in several biomedical applications with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The emergence of novel nanotechnology techniques, such as electrospinning, has proven to be an excellent option for nanotechnology, ensuring effective drug delivery system recognised medicinal plant extracts containing polyphenols electrospun nanofibers can provide the necessary environment encapsulation. Together, have shown promising usage wound healing. When are incorporated into nanofibrous scaffolds, their combined properties enhance cell attachment, proliferation, differentiation. This review explores potential polyphenol-loaded therapy, highlighting importance efficient systems polyphenols. It provides brief assessment specific (resveratrol, curcumin, thymol, quercetin, tannic acid, ferulic hesperidin, gallic kaempferol, chlorogenic acid) that been successfully encapsulated applied treatment. Despite ongoing research, certain carvacrol, oleuropein, kaempferol remain less explored. underscores need continued investigation these while recognising growing application healing more extensive therapeutic use.

Язык: Английский

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Psychodermatology of Chronic Pruritus: An Overview of the Link Between Itch and Distress

Dermatology and Therapy, Год журнала: 2024, Номер 14(7), С. 1799 - 1809

Опубликована: Июнь 24, 2024

Chronic pruritus (CP) is defined as an unpleasant sensation causing a desire to scratch and lasting > 6 weeks. It has multifactorial etiology but more frequently associated with chronic inflammatory dermatoses systemic disorders. Psychogenic neurological disorders are other less common etiologies, while, in some patients, it idiopathic. CP appears be processed by non-histaminergic pathway, contributing its complexity therapeutic challenge. Moreover, regardless of the etiology, multidimensional, including cognitive, motivational affective components. There close link between psychological distress pruritus, particular clinical expression dermatoses, involving activation hypothalamic-pituitary-adrenal axis (and cutaneous equivalent), sympathetic nervous system, release hormones peptides, role immune cells (T B cells, macrophages) immune-related skin (mast dendritic keratinocytes). there strong evidence that factors influence experience pruritus. can also cause psychiatric disorders, not limited anxiety depression, lead significant quality life (QoL) impairment. Thereby, although psychodermatological assessment should ideally carried out context specific psychodermatology consultation, brief mental health could part general dermatological approach these patients. Considering health, QoL closely linked, psychotherapeutic interventions and/or psychotropic drugs thus considered patients adjunct pharmacological treatment CP.

Язык: Английский

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‘A boy actually said I looked like a fire victim’: Exploring the psychosocial impacts of psoriasis, eczema and acne amongst young women in the UK through thematic analysis

Journal of Health Psychology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Our knowledge of the psychosocial implications skin conditions continues to broaden, as research identifies multiple psychological morbidities relating psoriasis, eczema and acne. This includes findings poor body image, a result change in physical appearance skin. However, there is limited qualitative UK that explores how young women with experience unique impacts, including image issues. The present study explored experiences seven Four main themes were developed: Embarrassment over related symptoms; An unrealistic female beauty standard; Change attacking personal identity; Lack support. these are discussed, call for biopsychosocial approach condition treatment, prioritises social well being patients, their health.

Язык: Английский

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Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 749 - 749

Опубликована: Янв. 17, 2025

Psoriasis is a chronic inflammatory condition that polygenic and multisystemic, impacting approximately 2-3% of the global population. The onset this disease influenced by an intricate interplay genetic environmental factors, predisposing individuals to psoriasis phenotype. complex pathogenesis contains certain key aspects found in other autoinflammatory autoimmune dermatological diseases. Among these, vitiligo, alopecia areata, hidradenitis suppurativa, connective tissue diseases, bullous dermatoses, atopic dermatitis are conditions share overlapping immune system dysfunction, making their relationship with particularly significant. For our research, we explored various terms including "shared", "concomitant", "coincident", "overlap", "coexist", "concurrent", relation such as "psoriasis", "alopecia areata", "hidradenitis suppurativa", "atopic dermatitis", "vitiligo", "bullous pemphigoid", "pemphigus vulgaris", "lupus erythematosus", "dermatomyositis", "systemic sclerosis." Additionally, used specific search queries like syndrome" "psoriasis vitiligo concomitant disease" PubMed Web Science databases. While distinct clinical presentation, skin diseases related may become associated, complicating diagnosis treatment. In narrative review, pathophysiology described, along its close conditions. This review provides exhaustive description both immunological non-immunological pathways contributing development. Understanding interconnection between these interest scientists developing novel research directions clinicians providing holistic care, managing one influence course others.

Язык: Английский

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Happiness – ein Konzept zur ganzheitlichen, personenzentrierten Gesundheitsversorgung in der Dermatologie

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Happiness ist ein Konzept der Positiven Psychologie. Studien belegen Zusammenhänge zwischen Happiness, Krankheitsverläufen und Gesundheit. In Dermatologie die Rolle von bisher wenig untersucht. Welchen Einfluss haben Hauterkrankungen auf individuelle welchen Beitrag kann zur ganzheitlichen dermatologischen Versorgung leisten? Aufbereitung aktuellen Literatur selektiven Übersicht wissenschaftlicher Primärarbeiten zu anhand heuristischer dem subjektiven Wohlbefinden gemessen am positiven negativen Affekt sowie Lebenszufriedenheit in Dermatologie. Patient:innen mit zeigen Einschränkungen ihrer insbesondere im verglichen gesunden Bevölkerung. Die scheinen bei verschiedenen Dermatosen unterschiedlich ausgeprägt sein; beispielsweise Hautkrebs eine deutlich höhere als andere dermatologische Patient:innen. Einflussfaktoren variieren Stärke Richtung abhängig Operationalisierung Hauterkrankung. Dermatologische Erkrankungen beim Affekt, verbunden sein. Integration könnte helfen, Bedürfnisse besser verstehen Sinne einer personenzentrierten Gesundheitsversorgung. Zukünftige Forschung spezifische Interventionen Verbesserung sollten entwickelt werden, um positive Gesundheitsergebnisse fördern.

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From Brain to Skin: Neurocosmetics Pave the Way into a No-Cosmetics Future

Regenerative Engineering and Translational Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Erythema along hemodialysis vascular access

International Urology and Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Язык: Английский

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The Impact of Perceived Stress and Parent-Child Relationship on the Quality of Life of Adolescents with Skin Diseases

Jundishapur journal of health sciences, Год журнала: 2025, Номер 17(2)

Опубликована: Март 2, 2025

Background: Adolescents with skin diseases often face significant challenges related to their physical appearance and social interactions. Objectives: The present study aimed investigate the correlation between perceived stress, parent-child relationships, quality of life in adolescents diseases. Methods: This descriptive-correlational was conducted on a sample (acne, lupus, vitiligo, psoriasis) referred hospitals superspecialty centers Babol, Iran 2023. A total 206 individuals were selected as sample. Data collection tools included questionnaires life, relationships. analyzed using Pearson coefficient stepwise regression. Results: Perceived stress demonstrated negative (r = -0.38, P < 0.001), whereas relationships exhibited positive 0.60, 0.001). Together, accounted for 38% variance among Furthermore, emerged stronger predictor this population. Conclusions: highlights correlations diseases, emphasizing need consider both psychological factors care. Future research should explore interventions at reduction family strengthening potentially improve well-being

Язык: Английский

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