Mechanism of medical hemorrhoid gel in relieving pruritus ani via inhibiting the activation of JAK2/STAT3 pathway DOI Creative Commons
Zhiyong Ai, D Yuan, Jingjing Cai

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 13, 2024

Background Pruritus ani (PA), a neurofunctional dermatosis, is one of the most common complications hemorrhoids, which seriously affects quality life patients. Medical hemorrhoid gel (MHG), product mainly composed herbal medicine, widely used for treatment PA clinically. This study aim to assess alleviating effect and mechanism MHG on based rectal epidermis-spinal cord-brain axis using animal models. Methods A chloroquine-induced mouse itching model croton oil preparation-induced rat were established evaluate anti-PA MHG. Scratching behaviors mice recorded, histopathology skin ano-rectal tissues was observed through H&E staining. Network pharmacology western blotting employed explore potential Results The indicated that significantly alleviated improved pathological injuries in tissues. suggested might regulate JAK/STAT signaling pathway. Experimental findings showed downregulated TRPV1 TRPA1 tissue, c-Fos GRPR spinal cord 5-HT1a protein brain while upregulating TRPM8 tissue. Furthermore, inhibited activation JAK2/STAT3 pathway axis. Conclusion improves by inhibiting transmission signals via pathway, providing experimental evidence its clinical application.

Язык: Английский

Decoding the inflammatory signature of the major depressive episode: insights from peripheral immunophenotyping in active and remitted condition, a case–control study DOI Creative Commons
Federico M. Daray, Leandro Nicolás Grendas,

Ángeles Romina Arena

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 12, 2024

Abstract Depression is a prevalent and incapacitating condition with significant impact on global morbidity mortality. Although the immune system’s role in its pathogenesis increasingly recognized, there lack of comprehensive understanding regarding involvement innate adaptive cells. To address this gap, we conducted multicenter case–control study involving 121 participants matched for sex age. These had either an active (or current) major depressive episode (MDE) (39 cases) or remitted MDE (40 cases), including individuals disorder bipolar disorder. We compared these 79 patients to 42 healthy controls (HC), analyzing their immunological profiles. In blood samples, determined complete cell count monocyte subtypes lymphocyte T-cell populations using flow cytometry. Additionally, measured panel cytokines, chemokines, neurotrophic factors plasma. Compared HC, people endorsing current showed monocytosis ( p = 0.001), increased high-sensitivity C-reactive protein 0.002), erythrocyte sedimentation rate 0.003), altered proportion specific subsets. CD4 lymphocytes presented median percentages activation markers CD69 + 0.007) exhaustion PD1 0.013) LAG3 0.014), as well higher frequency CD25 FOXP3 regulatory T cells 0.003). plasma levels sTREM2 0.0089). changes are more likely state markers, indicating presence ongoing inflammatory response during MDE. The Random Forest model achieved remarkable classification accuracies 83.8% vs. HC 70% differentiating Interestingly, cluster analysis identified three distinct profiles among patients. Cluster 1 has highest number leukocytes, mainly given by increment lowest proinflammatory cytokine levels. 3 displayed most robust pattern, high TNFα, CX3CL1, IL-12p70, IL-17A, IL-23, IL-33, associated level IL-10, β-NGF BDNF. This profile also absolute percentage circulating monocytes lymphocytes, denoting process. 2 some cardinal signs acute inflammation, such elevated CCL2 cytokines IL-1β, IFNγ, CXCL8. Similarly, closer value, suggesting possible initiation provides new insights into MDE, paving ground replication prospective studies targeting development diagnostic prognostic tools therapeutic targets.

Язык: Английский

Процитировано

7
Immune links in comorbid depression and psoriasis: a narrative mini-review and perspective DOI Creative Commons
Georgia Lada

Brain Behavior & Immunity - Health, Год журнала: 2025, Номер 44, С. 100949 - 100949

Опубликована: Янв. 15, 2025

Язык: Английский

Процитировано

0
MRI-based neuroimaging alterations in immune-related skin diseases: a comprehensive review DOI
Song Tan, Ziyan Chen, Yunyao Liu

и другие.

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Март 8, 2025

Язык: Английский

Процитировано

0
Molecular Link Between Psoriasis and Depression—Update on Pathophysiology DOI Open Access
Agnieszka Hołdrowicz, Agnieszka Żebrowska

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2467 - 2467

Опубликована: Март 10, 2025

Psoriasis disease is a chronic, systemic condition. Various epidemiological studies have indicated connection between psoriasis and psychiatric diseases. It obvious that easily visible psoriatic skin lesions cause stigmatization of patients impact noticeably their life quality, increasing the risk anxiety depressive disorders. More more attention recently being paid to common pathogenesis depression. The underlying chronic inflammation, depression also increasingly recognized as result neuroinflammation. Therefore, complexity processes both entities implies need observe in terms possible comorbidities, such mental disorders, regardless severity social stigmatization. This study aims present an update on pathophysiology

Язык: Английский

Процитировано

0
Personalized prediction of psoriasis relapse post-biologic discontinuation: a machine learning-driven population cohort study DOI Creative Commons
Shan Huang, Yanping Bai,

Ruili Qi

и другие.

Journal of Dermatological Treatment, Год журнала: 2025, Номер 36(1)

Опубликована: Март 19, 2025

Background Identifying the risk of psoriasis relapse after discontinuing biologics can help optimize treatment strategies, potentially reducing rates and alleviating burden disease management.

Язык: Английский

Процитировано

0
Psoriasis: A Multidimensional Review of Onset, Progression, Treatment, and the Evolution of Disease Models DOI
Yanhong Pan,

Jueyao Zou,

Tianlong Hu

и другие.

Molecular Diagnosis & Therapy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Mechanism of medical hemorrhoid gel in relieving pruritus ani via inhibiting the activation of JAK2/STAT3 pathway DOI Creative Commons
Zhiyong Ai, D Yuan, Jingjing Cai

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Ноя. 13, 2024

Background Pruritus ani (PA), a neurofunctional dermatosis, is one of the most common complications hemorrhoids, which seriously affects quality life patients. Medical hemorrhoid gel (MHG), product mainly composed herbal medicine, widely used for treatment PA clinically. This study aim to assess alleviating effect and mechanism MHG on based rectal epidermis-spinal cord-brain axis using animal models. Methods A chloroquine-induced mouse itching model croton oil preparation-induced rat were established evaluate anti-PA MHG. Scratching behaviors mice recorded, histopathology skin ano-rectal tissues was observed through H&E staining. Network pharmacology western blotting employed explore potential Results The indicated that significantly alleviated improved pathological injuries in tissues. suggested might regulate JAK/STAT signaling pathway. Experimental findings showed downregulated TRPV1 TRPA1 tissue, c-Fos GRPR spinal cord 5-HT1a protein brain while upregulating TRPM8 tissue. Furthermore, inhibited activation JAK2/STAT3 pathway axis. Conclusion improves by inhibiting transmission signals via pathway, providing experimental evidence its clinical application.

Язык: Английский

Процитировано

0