Preliminary evidence of immune infiltration and neutrophil degranulation in peripheral blood of non-obese OSA patients related to cognitive decline
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 28, 2025
Obstructive
sleep
apnea
(OSA)
patients
have
varying
degrees
of
cognitive
impairment,
but
the
specific
pathogenic
mechanism
is
still
unclear.
Meanwhile,
poor
compliance
with
continuous
positive
airway
pressure
(CPAP)
in
OSA
prompts
better
solutions.
This
study
aimed
to
identify
differentially
expressed
genes
between
non-obese
and
healthy
controls,
explore
potential
biomarkers
associated
impairment.
Cohorts
control
(n
=
20)
non-obese,
treatment-naïve
were
recruited.
We
collected
their
peripheral
blood
mononuclear
cells
neutrophils,
performances
evaluated
by
Montreal
Cognitive
Assessment
(MoCA).
The
identified
bioinformatic
analysis
confirmed
PCR.
Imbalanced
immune
cell
proportions
assessed
Cibersort.
Biomarkers
related
enriched
cellular
pathways
measured
ELISA.
showed
a
significant
decline
overall
function
higher
daytime
sleepiness
scores.
Multiple
signaling
cohort,
including
upregulation
neutrophil-degranulation.
Increased
monocyte
proportion
decreased
NK
figured
out.
relevant
genes,
upregulated
defensin
alpha
4
(DEFA4),
haptoglobin
(HP),
survivin
(BIRC5),
suppressed
interferon
gamma
(IFNG)
expression
detected.
relative
DEFA4
was
significantly
correlated
MoCA
score
parameters.
such
as
myeloperoxidase
(MPO),
H2O2,
lipocalin-2,
representatives
neutrophils'
activation,
elevated
group.
data
demonstrated
correlation
MPO
oxygen
desaturation
index
(ODI)
negative
lowest
saturation
(LSaO2).
level
Lipocalin-2
positively
apnea-hypopnea
(AHI)
ODI
negatively
LSaO2
score.
also
observed
H2O2
mean
(MSaO2).
Degranulation
neutrophils
activated
without
other
complications.
process
severity
implying
its
role
pathogenesis.
Язык: Английский
Esketamine alleviates cognitive impairment signs induced by modified electroconvulsive therapy in a depression rat model via the KLF4/p38 MAPK pathway
Journal of Affective Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Neurobiological perturbations in bipolar disorder compared to schizophrenia – evidence from cell cultures and brain organoids
Biological Psychiatry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
NLRP3 inflammasome mediates astroglial dysregulation of innate and adaptive immune responses in schizophrenia
Brain Behavior and Immunity,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls
Psychological Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Окт. 2, 2024
Abstract
Background
While
inflammation
is
associated
with
cognitive
impairment
in
severe
mental
illnesses
(SMI),
there
substantial
heterogeneity
and
evidence
of
transdiagnostic
subgroups
across
schizophrenia
(SZ)
bipolar
(BD)
spectrum
disorders.
There
however,
limited
knowledge
about
the
longitudinal
course
this
relationship.
Methods
Systemic
(C-Reactive
Protein,
CRP)
cognition
(nine
domains)
was
measured
from
baseline
to
1
year
follow-up
first
treatment
SZ
BD
(
n
=
221),
healthy
controls
(HC,
220).
Linear
mixed
models
were
used
evaluate
changes
separately
CRP
domains
specific
diagnostic
status
(SZ,
BD,
HC).
Hierarchical
clustering
applied
on
entire
sample
investigate
inflammatory-cognitive
subgroups.
Results
no
case-control
differences
or
change
follow-up.
We
confirm
previous
observations
at
both
time-points
domain
stability/improvement
over
time
regardless
status.
identified
differing
demographics
clinical
severity.
Despite
improvement
cognition,
symptoms
functioning,
higher
–
lower
subgroup
(75%
SZ;
48%
BD;
38%
HC)
had
sustained
more
symptoms,
functioning
(SMI
only)
This
comparison
a
(25%
SZ,
52%
62%
HC),
where
SMI
participants
showed
HC
level
positive
course.
Conclusions
Our
findings
support
heterogenous
that
are
stable
time,
may
benefit
targeted
interventions.
Язык: Английский
Correspondence to Sæther et al. Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain
Brain Behavior and Immunity,
Год журнала:
2024,
Номер
118, С. 521 - 522
Опубликована: Март 19, 2024
Язык: Английский
Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 9, 2024
Abstract
Background
While
inflammation
is
associated
with
cognitive
impairment
in
severe
mental
illnesses
(SMI),
there
substantial
heterogeneity
and
evidence
of
transdiagnostic
subgroups
across
schizophrenia
(SZ)
bipolar
(BD)
spectrum
disorders.
There
however,
limited
knowledge
about
the
longitudinal
course
this
relationship.
Methods
Systemic
(C-Reactive
Protein,
CRP)
cognition
(nine
domains)
was
measured
from
baseline
to
1
year
follow-up
first
treatment
SZ
BD
(n=221),
healthy
controls
(HC,
n=220).
Linear
mixed
models
were
used
evaluate
changes
separately
CRP
domains
specific
diagnostic
status
(SZ,
BD,
HC).
Hierarchical
clustering
applied
on
entire
sample
investigate
inflammatory-cognitive
subgroups.
Results
no
case-control
differences
or
change
follow-up.
We
confirm
previous
observations
at
both
time-points
domain
stability/improvement
over
time
regardless
status.
identified
differing
demographics
clinical
severity.
Despite
improvement
cognition,
symptoms
functioning,
higher
–
lower
subgroup
(75%
SZ;
48%
BD;
38%
HC)
had
sustained
more
symptoms,
functioning
(SMI
only)
This
comparison
a
(25%
SZ,
52%
62%
HC),
where
SMI
participants
showed
HC
level
positive
course.
Conclusions
Our
findings
support
heterogenous
that
are
stable
time,
may
benefit
targeted
interventions.
Язык: Английский