Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls DOI Creative Commons
Linn Sofie Sæther, Thor Ueland, Beathe Haatveit

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Abstract Background While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) bipolar (BD) spectrum disorders. There however, limited knowledge about the longitudinal course this relationship. Methods Systemic (C-Reactive Protein, CRP) cognition (nine domains) was measured from baseline to 1 year follow-up first treatment SZ BD (n=221), healthy controls (HC, n=220). Linear mixed models were used evaluate changes separately CRP domains specific diagnostic status (SZ, BD, HC). Hierarchical clustering applied on entire sample investigate inflammatory-cognitive subgroups. Results no case-control differences or change follow-up. We confirm previous observations at both time-points domain stability/improvement over time regardless status. identified differing demographics clinical severity. Despite improvement cognition, symptoms functioning, higher – lower subgroup (75% SZ; 48% BD; 38% HC) had sustained more symptoms, functioning (SMI only) This comparison a (25% SZ, 52% 62% HC), where SMI participants showed HC level positive course. Conclusions Our findings support heterogenous that are stable time, may benefit targeted interventions.

Language: Английский

Preliminary evidence of immune infiltration and neutrophil degranulation in peripheral blood of non-obese OSA patients related to cognitive decline DOI Creative Commons
Qingqing Liu,

Yanru Ou,

Ting Liu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 28, 2025

Obstructive sleep apnea (OSA) patients have varying degrees of cognitive impairment, but the specific pathogenic mechanism is still unclear. Meanwhile, poor compliance with continuous positive airway pressure (CPAP) in OSA prompts better solutions. This study aimed to identify differentially expressed genes between non-obese and healthy controls, explore potential biomarkers associated impairment. Cohorts control (n = 20) non-obese, treatment-naïve were recruited. We collected their peripheral blood mononuclear cells neutrophils, performances evaluated by Montreal Cognitive Assessment (MoCA). The identified bioinformatic analysis confirmed PCR. Imbalanced immune cell proportions assessed Cibersort. Biomarkers related enriched cellular pathways measured ELISA. showed a significant decline overall function higher daytime sleepiness scores. Multiple signaling cohort, including upregulation neutrophil-degranulation. Increased monocyte proportion decreased NK figured out. relevant genes, upregulated defensin alpha 4 (DEFA4), haptoglobin (HP), survivin (BIRC5), suppressed interferon gamma (IFNG) expression detected. relative DEFA4 was significantly correlated MoCA score parameters. such as myeloperoxidase (MPO), H2O2, lipocalin-2, representatives neutrophils' activation, elevated group. data demonstrated correlation MPO oxygen desaturation index (ODI) negative lowest saturation (LSaO2). level Lipocalin-2 positively apnea-hypopnea (AHI) ODI negatively LSaO2 score. also observed H2O2 mean (MSaO2). Degranulation neutrophils activated without other complications. process severity implying its role pathogenesis.

Language: Английский

Citations

0

Esketamine alleviates cognitive impairment signs induced by modified electroconvulsive therapy in a depression rat model via the KLF4/p38 MAPK pathway DOI
Xiaohui Zhou, Li Zhang, Weiwei Gao

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0

Neurobiological perturbations in bipolar disorder compared to schizophrenia – evidence from cell cultures and brain organoids DOI Creative Commons
Ibrahim A. Akkouh, Jordi Requena Osete, Attila Szabó

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0

NLRP3 inflammasome mediates astroglial dysregulation of innate and adaptive immune responses in schizophrenia DOI Creative Commons
Attila Szabó, Ibrahim A. Akkouh, Jordi Requena Osete

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

3

Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls DOI
Linn Sofie Sæther, Thor Ueland, Beathe Haatveit

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Oct. 2, 2024

Abstract Background While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) bipolar (BD) spectrum disorders. There however, limited knowledge about the longitudinal course this relationship. Methods Systemic (C-Reactive Protein, CRP) cognition (nine domains) was measured from baseline to 1 year follow-up first treatment SZ BD ( n = 221), healthy controls (HC, 220). Linear mixed models were used evaluate changes separately CRP domains specific diagnostic status (SZ, BD, HC). Hierarchical clustering applied on entire sample investigate inflammatory-cognitive subgroups. Results no case-control differences or change follow-up. We confirm previous observations at both time-points domain stability/improvement over time regardless status. identified differing demographics clinical severity. Despite improvement cognition, symptoms functioning, higher – lower subgroup (75% SZ; 48% BD; 38% HC) had sustained more symptoms, functioning (SMI only) This comparison a (25% SZ, 52% 62% HC), where SMI participants showed HC level positive course. Conclusions Our findings support heterogenous that are stable time, may benefit targeted interventions.

Language: Английский

Citations

1

Correspondence to Sæther et al. Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain DOI
Rikas Saputra,

Setyorini,

Siti Aminah

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 521 - 522

Published: March 19, 2024

Language: Английский

Citations

0

Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls DOI Creative Commons
Linn Sofie Sæther, Thor Ueland, Beathe Haatveit

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Abstract Background While inflammation is associated with cognitive impairment in severe mental illnesses (SMI), there substantial heterogeneity and evidence of transdiagnostic subgroups across schizophrenia (SZ) bipolar (BD) spectrum disorders. There however, limited knowledge about the longitudinal course this relationship. Methods Systemic (C-Reactive Protein, CRP) cognition (nine domains) was measured from baseline to 1 year follow-up first treatment SZ BD (n=221), healthy controls (HC, n=220). Linear mixed models were used evaluate changes separately CRP domains specific diagnostic status (SZ, BD, HC). Hierarchical clustering applied on entire sample investigate inflammatory-cognitive subgroups. Results no case-control differences or change follow-up. We confirm previous observations at both time-points domain stability/improvement over time regardless status. identified differing demographics clinical severity. Despite improvement cognition, symptoms functioning, higher – lower subgroup (75% SZ; 48% BD; 38% HC) had sustained more symptoms, functioning (SMI only) This comparison a (25% SZ, 52% 62% HC), where SMI participants showed HC level positive course. Conclusions Our findings support heterogenous that are stable time, may benefit targeted interventions.

Language: Английский

Citations

0