Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Фев. 13, 2025

Introduction While the influence of both genetic and environmental factors on development psychiatric symptoms is well-recognized, precise nature their interaction throughout remains a subject ongoing debate. This study investigated association between expression 78 candidate genes, previously associated with phenotypes, in peripheral blood adversity psychopathology sample 298 young individuals assessed at two time points from Brazilian High Risk Cohort Study for Mental Conditions (BHRCS). Methods Psychopathology was using Child Behavior Checklist (CBCL), considering total CBCL, p-factor (i.e. general factor psychopathology), internalizing externalizing as clinical variables. The life adversities considered this includes four composite variables: child maltreatment, stressful events, threat deprivation. Gene measured next-generation sequencing target genes differential gene analyzed DESeq2 package. Results Mixed models revealed six symptoms: NR3C1, HSPBP1, SIN3A, SMAD4, CRLF3 exhibited negative correlation these symptoms, while FAR1 showed positive correlation. Additionally, we also found USP38 symptoms. Finally, DENND11 PRRC1 were negatively deprivation, latent characterized by neglect, parental absence, measures material forms No mediation or moderation effect observed meaning that they might distinct pathways. Discussion Among nine which encodes glucocorticoid receptor, far most investigated, being depressive early adversity, stress. further research needed to fully understand complex relationship expression, adversities, psychopathology, our findings provide valuable insights into molecular mechanisms underlying mental disorders.

Язык: Английский

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Differential immune profiles in the context of chronic stress among childhood adversity-exposed adolescents

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Leukocytes: Likely not the immune system’s white knights in the wake of early life adversity

Brain Behavior and Immunity, Год журнала: 2024, Номер 121, С. 70 - 71

Опубликована: Июль 21, 2024

Язык: Английский

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