Integrative Multi-Omics and Mendelian Randomisation Reveal Key Circulating Mediators Linking Type 2 Diabetes to Coronary Atherosclerosis
Опубликована: Янв. 1, 2025
Язык: Английский
Circulating tsRNAs serve as potential biomarkers for predicting postoperative delirium in elderly patients receiving lower extremity orthopedic surgery
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
16
Опубликована: Март 26, 2025
Background
Postoperative
delirium
(POD)
is
a
serious
neuropsychiatric
complication
in
elderly
surgical
patients,
yet
its
pathogenesis
remains
incompletely
understood.
Transfer
RNA-derived
small
RNAs
(tsRNAs)
have
emerged
as
crucial
regulators
neurological
disorders.
We
investigated
whether
specific
tsRNAs
could
serve
predictive
biomarkers
for
POD.
Methods
This
study
conducted
prospective
case-control
of
158
patients
(≥60
years)
undergoing
orthopedic
surgery.
Plasma
samples
were
collected
preoperatively
and
on
postoperative
day
3.tsRNA
expression
profiles
analyzed
using
RNA
sequencing
validated
by
RT-qPCR.
Propensity
score
matching
was
performed
to
balance
demographic
clinical
variables.
The
value
candidate
assessed
ROC
analysis,
their
potential
functions
explored
through
bioinformatic
analyses.
Results
Among
128
non-POD
30
POD
two
(Other-14:
31-tRNA-Gly-CCC-3
Other-39:
73-tRNA-Arg-TCG-5)
showed
significantly
elevated
preoperative
levels
(p<0.001).ROC
analysis
revealed
strong
performance
(AUC=0.868
0.956,
respectively).These
differences
persisted
the
propensity-matched
cohort
(29
pairs).Bioinformatic
analyses
indicated
enrichment
pathways
related
neurotransmission,
inflammation,
metabolism.
Conclusion
identified
novel
tsRNA
that
robustly
predict
risk
provide
insights
into
molecular
pathogenesis.
These
findings
may
facilitate
early
stratification
preventive
interventions.
Язык: Английский
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
Journal of the Neurological Sciences,
Год журнала:
2024,
Номер
467, С. 123291 - 123291
Опубликована: Ноя. 8, 2024
Язык: Английский