Integrative Multi-Omics and Mendelian Randomisation Reveal Key Circulating Mediators Linking Type 2 Diabetes to Coronary Atherosclerosis

Published: Jan. 1, 2025

Language: Английский

Circulating tsRNAs serve as potential biomarkers for predicting postoperative delirium in elderly patients receiving lower extremity orthopedic surgery

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Postoperative delirium (POD) is a serious neuropsychiatric complication in elderly surgical patients, yet its pathogenesis remains incompletely understood. Transfer RNA-derived small RNAs (tsRNAs) have emerged as crucial regulators neurological disorders. We investigated whether specific tsRNAs could serve predictive biomarkers for POD. Methods This study conducted prospective case-control of 158 patients (≥60 years) undergoing orthopedic surgery. Plasma samples were collected preoperatively and on postoperative day 3.tsRNA expression profiles analyzed using RNA sequencing validated by RT-qPCR. Propensity score matching was performed to balance demographic clinical variables. The value candidate assessed ROC analysis, their potential functions explored through bioinformatic analyses. Results Among 128 non-POD 30 POD two (Other-14: 31-tRNA-Gly-CCC-3 Other-39: 73-tRNA-Arg-TCG-5) showed significantly elevated preoperative levels (p<0.001).ROC analysis revealed strong performance (AUC=0.868 0.956, respectively).These differences persisted the propensity-matched cohort (29 pairs).Bioinformatic analyses indicated enrichment pathways related neurotransmission, inflammation, metabolism. Conclusion identified novel tsRNA that robustly predict risk provide insights into molecular pathogenesis. These findings may facilitate early stratification preventive interventions.

Language: Английский

Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 467, P. 123291 - 123291

Published: Nov. 8, 2024

Language: Английский