Research on drug treatment and the novel signaling pathway of chronic atrophic gastritis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116912 - 116912

Опубликована: Июнь 7, 2024

Chronic atrophic gastritis (CAG) is a global digestive system disease and one of the important causes gastric cancer. The incidence CAG has been increasing yearly worldwide.

Язык: Английский

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FHL3 gene regulates bovine skeletal muscle cell growth through the PI3K/Akt/mTOR signaling pathway

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Год журнала: 2024, Номер 52, С. 101356 - 101356

Опубликована: Ноя. 7, 2024

Язык: Английский

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Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis

Redox Biology, Год журнала: 2024, Номер 76, С. 103333 - 103333

Опубликована: Авг. 30, 2024

Sarcopenia, a prevalent condition, significantly impacts the prognosis of patients with decompensated cirrhosis (DC). Serum fibroblast growth factor 21 (FGF21) levels are higher in DC sarcopenia. Satellite cells (SCs) play role aging- and cancer-induced Here, we investigated roles FGF21 SCs DC-related sarcopenia as well underlying mechanisms. We developed two mouse models performed vivo vitro experiments. Klotho beta (KLB) knockout mice were constructed to investigate KLB downstream FGF21. In addition, biological samples collected from control validate results. Muscle wasting impaired SC myogenesis observed model DC. Elevated circulating liver-derived observed, which negatively correlated skeletal muscle mass/skeletal index. Liver-secreted induces dysfunction, contributing Mechanistically, state exhibits enhanced interactions on surfaces, leading phosphatase tensin homolog upregulation. This inhibits protein kinase B (PI3K/Akt) pathway, hampering proliferation differentiation, blocking new myotube formation repair atrophy. Neutralizing using neutralizing antibodies, knockdown hepatic by adeno-associated virus, or effectively improved reversed Hepatocyte-derived mediates liver-muscle crosstalk, impairs regeneration via inhibition PI3K/Akt thereby demonstrating novel therapeutic strategy for

Язык: Английский

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The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer

Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101567 - 101567

Опубликована: Фев. 1, 2025

Язык: Английский

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Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Май 19, 2025

Precancerous lesions of the stomach (PLGC), a critical stage in gastric cancer development, have garnered significant attention for its prevention and treatment. PLGC refers to series pathological histological changes preceding cancer. Due complex pathogenesis multi-factor influence, no currently existing drug can effectively prevent or delay this process. Therefore, identifying safe effective treatment method remains an important research focus. In recent years, traditional Chinese medicine has demonstrated unique advantages potential Many studies focused on regulation medicine's active ingredients relevant signaling pathways. Studies show regulate cell proliferation, apoptosis, differentiation, autophagy, oxidative stress, inflammatory response via multi-target, multi-pathway intervention key pathways like hypoxia-inducible factor 1 (HIF-1α), nuclear kappa-B (NF-κB), wingless-type MMTV integration site family/beta-catenin (Wnt/β-catenin), phosphoinositide 3-kinases/Protein kinase B (PI3K/AKT), Sonic Hedgehog (Shh), Janus kinase/signal transducer activator transcription (JAK/STAT), mitogen-activated protein (MAPK), erythroid 2-related 2 (Nrf2), more, thereby delaying reversing progression. This paper summarizes sorts these by ingredients, seeking provide theoretical basis medication reference with medicine.

Язык: Английский

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Mutual information stacking method for prediction of the growth traits in pigs

Briefings in Bioinformatics, Год журнала: 2025, Номер 26(3)

Опубликована: Май 1, 2025

Genomic prediction is a crucial technique for phenotype estimation, with the genomic best linear unbiased (GBLUP) being most widely adopted method. Yet, GBLUP falls short in capturing intricate nonlinear relationships between data and phenotypes. Given its ability to more effectively capture genetic effects, machine learning (ML) has become increasingly appealing prediction. However, almost ML methods utilize all single nucleotide polymorphisms (SNPs) prediction, ignoring fact that only subset of SNPs are effective. This not consumes computation time but also poor accuracy. So, this paper proposed mutual information stacking method (MISM). Firstly, was introduced select effect remove redundant SNPs. Then, we constructed model can both phenotypes improve To assess effectiveness MISM, compared performance on pig growth traits other methods. The statistical analysis results indicated MISM outperformed models GBLUP.

Язык: Английский

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Muscle‐specific pyruvate kinase isoforms, PKM1 and PKM2, regulate mammalian SWI/SNF proteins and histone 3 phosphorylation during myoblast differentiation

The FASEB Journal, Год журнала: 2024, Номер 38(11)

Опубликована: Июнь 4, 2024

Abstract Pyruvate kinase is a glycolytic enzyme that converts phosphoenolpyruvate and ADP into pyruvate ATP. There are two genes encode in vertebrates; Pkm Pkl muscle‐ liver/erythrocyte‐specific forms, respectively. Each gene encodes isoenzymes due to alternative splicing. Both muscle‐specific enzymes, PKM1 PKM2, function glycolysis, but PKM2 also has been implicated regulation its ability phosphorylate histone 3 threonine 11 (H3T11) cancer cells. Here, we examined the roles of during myoblast differentiation. RNA‐seq analysis revealed promotes expression Dpf2/Baf45d Baf250a/Arid1A . DPF2 BAF250a subunits identify specific sub‐family mammalian SWI/SNF (mSWI/SNF) chromatin remodeling enzymes required for activation myogenic mediated incorporation regulatory sequences controlling expression. did not affect was nuclear localization DPF2. Additionally, only phosphorylated H3T11 promoters H3T6 H3T45 at via AKT protein C isoforms those amino acids. Our results multiple unique novel

Язык: Английский

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CircRNA profiling of skeletal muscle satellite cells in goats reveals circTGFβ2 promotes myoblast differentiation

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Ноя. 12, 2024

Circular RNAs (circRNAs) function as essential regulatory elements with pivotal roles in various biological processes. However, their expression profiles and functional regulation during the differentiation of goat myoblasts have not been thoroughly explored. This study conducts an analysis circRNA proliferation phase (cultured growth medium, GM) DM1/DM5) skeletal muscle satellite cells (MuSCs) goats.

Язык: Английский

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Circular RNAs and host genes act synergistically in regulating cellular processes and functions in skeletal myogenesis

Gene, Год журнала: 2024, Номер unknown, С. 149189 - 149189

Опубликована: Дек. 1, 2024

Язык: Английский

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MEK inhibitors and DA‐Raf, a dominant‐negative antagonist of the Ras–ERK pathway, prevent the migration and invasion of KRAS‐mutant cancer cells

Cytoskeleton, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract The Ras‐induced ERK pathway (Raf–MEK–ERK signaling cascade) regulates a variety of cellular responses including cell proliferation, survival, and migration. Activating mutations in RAS genes, particularly the KRAS gene, constitutively activate pathway, resulting tumorigenesis, cancer invasion, metastasis. DA‐Raf1 (DA‐Raf) is splicing isoform A‐Raf contains Ras‐binding domain but lacks kinase domain. Consequently, DA‐Raf antagonizes Ras–ERK dominant‐negative manner can serve as tumor suppressor that targets mutant Ras protein‐induced tumorigenesis. We show here MEK inhibitors interfere with vitro collective migration invasion human ‐mutant carcinoma lines, lung adenocarcinoma A549, colorectal HCT116, pancreatic MIA PaCa‐2 cells. expression was silenced these lines. All lines had high abilities properties Matrigel, compared nontumor Their were impaired by suppressing U0126 trametinib, an approved anticancer drug. Expression cells reduced activity hindered abilities. Therefore, may function protein blocking when induced invasive

Язык: Английский

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