Mitochondria: great balls of fire

FEBS Journal, Год журнала: 2024, Номер 291(24), С. 5327 - 5341

Опубликована: Ноя. 14, 2024

Recent experimental studies indicate that mitochondria in mammalian cells are maintained at temperatures of least 50 °C. While acknowledging the limitations current methods and their interpretation, we here consider ramifications this finding for cellular functions evolution. We whether as heat-producing organelles had a role origin eukaryotes emergence homeotherms. The homeostatic responses mitochondrial temperature to externally applied heat imply existence molecular heat-sensing system mitochondria. findings high innermost compartments mitochondria, those surface immediately surrounding cytosol remain be determined. ask some aspects dynamics motility could reflect changes supply demand heat, production factor diseases immunity.

Язык: Английский

Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation

Smart Materials in Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Advances in research on mitochondrial dysfunction in neurodegenerative diseases

Journal of Neurology, Год журнала: 2025, Номер 272(5)

Опубликована: Апрель 28, 2025

Язык: Английский