Mitochondria: great balls of fire DOI Creative Commons
Howard T. Jacobs, Pierre Rustin, Paule Bénit

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: 291(24), P. 5327 - 5341

Published: Nov. 14, 2024

Recent experimental studies indicate that mitochondria in mammalian cells are maintained at temperatures of least 50 °C. While acknowledging the limitations current methods and their interpretation, we here consider ramifications this finding for cellular functions evolution. We whether as heat-producing organelles had a role origin eukaryotes emergence homeotherms. The homeostatic responses mitochondrial temperature to externally applied heat imply existence molecular heat-sensing system mitochondria. findings high innermost compartments mitochondria, those surface immediately surrounding cytosol remain be determined. ask some aspects dynamics motility could reflect changes supply demand heat, production factor diseases immunity.

Language: Английский

Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation DOI Creative Commons
O. Yu. Antonova, O. Yu. Kochetkova,

Maxim Tailakov

et al.

Smart Materials in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advances in research on mitochondrial dysfunction in neurodegenerative diseases DOI
Yao Zhang, Xiaowen Li,

Yuan Zhang

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(5)

Published: April 28, 2025

Language: Английский

Citations

0
Mitochondria: great balls of fire DOI Creative Commons
Howard T. Jacobs, Pierre Rustin, Paule Bénit

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: 291(24), P. 5327 - 5341

Published: Nov. 14, 2024

Recent experimental studies indicate that mitochondria in mammalian cells are maintained at temperatures of least 50 °C. While acknowledging the limitations current methods and their interpretation, we here consider ramifications this finding for cellular functions evolution. We whether as heat-producing organelles had a role origin eukaryotes emergence homeotherms. The homeostatic responses mitochondrial temperature to externally applied heat imply existence molecular heat-sensing system mitochondria. findings high innermost compartments mitochondria, those surface immediately surrounding cytosol remain be determined. ask some aspects dynamics motility could reflect changes supply demand heat, production factor diseases immunity.

Language: Английский

Citations

3