ACS Medicinal Chemistry Letters, Год журнала: 2023, Номер 14(8), С. 1047 - 1048
Опубликована: Авг. 1, 2023
Provided herein are novel pyridazine derivatives as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating asthma, COPD, Parkinson's disease, and Alzheimer's processes for preparing compounds.
Язык: Английский
Physiological Reviews, Год журнала: 2023, Номер 103(4), С. 2847 - 2892
Опубликована: Июль 13, 2023
The kidneys play a key role in maintaining total body homeostasis. complexity of this task is reflected the unique architecture organ. Ureteral obstruction greatly affects renal physiology by altering hemodynamics, changing glomerular filtration and metabolism, inducing architectural malformations kidney parenchyma, most importantly fibrosis. Persisting pathological changes lead to chronic disease, which currently ∼10% global population one major causes death worldwide. Studies on consequences ureteral date back 1800s. Even today, experimental unilateral (UUO) remains standard model for tubulointerstitial However, has certain limitations when it comes studying tubular injury repair, as well limited potential human translation. Nevertheless, provided scientific community with wealth knowledge (patho)physiology. With introduction advanced omics techniques, classical UUO remained relevant day been instrumental understanding fibrosis at molecular, genomic, cellular levels. This review details concepts recent advances obstructive nephropathy, highlighting pathophysiological hallmarks responsible functional induced obstruction, special emphasis
Язык: Английский
Процитировано
64
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Май 13, 2024
Abstract Macrophages are exceptionally diversified cell types and perform unique features functions when exposed to different stimuli within the specific microenvironment of various kidney diseases. In instances tissue necrosis or infection, patterns associated with damage pathogens prompt development pro-inflammatory macrophages (M1). These M1 contribute exacerbating damage, inflammation, eventual fibrosis. Conversely, anti-inflammatory (M2) arise in same circumstances, contributing repair regeneration processes. Impaired causes fibrosis, hence play a protective pathogenic role. response harmful body, inflammasomes, complex assemblies multiple proteins, assume pivotal function innate immunity. The initiation inflammasomes triggers activation caspase 1, which turn facilitates maturation cytokines, death. kidneys possess complete elements NLRP3 inflammasome, including NLRP3, ASC, pro-caspase-1. When activated, it caspase-1, resulting release mature proinflammatory cytokines (IL)-1β IL-18 cleavage Gasdermin D (GSDMD). This process therefore then induces pyroptosis, leading renal death, dysfunction. NLRP3–ASC–caspase-1–IL-1β–IL-18 pathway has been identified as factor pathophysiology numerous this review, we explore current progress understanding macrophage behavior concerning injury, fibrosis kidneys. Emphasizing role activated both advancement recovery phases diseases, article delves into potential strategies modify functionality also discusses emerging approaches selectively target their signaling components kidney, aiming facilitate healing
Язык: Английский
Процитировано
22
Metabolism, Год журнала: 2024, Номер 155, С. 155913 - 155913
Опубликована: Апрель 11, 2024
Язык: Английский
Процитировано
19
Cells, Год журнала: 2023, Номер 12(12), С. 1584 - 1584
Опубликована: Июнь 8, 2023
Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the global population. encompasses diverse group disorders that vary in their underlying pathophysiology, clinical presentation, and outcomes. These include acute kidney injury (AKI), chronic (CKD), glomerulonephritis, nephrotic syndrome, polycystic disease, diabetic many others. Despite distinct etiologies, these share common feature immune system dysregulation metabolic disturbances. The pathways are intimately connected interact to modulate pathogenesis diseases. responses diseases includes complex interplay between various cell types, including resident infiltrating cells, cytokines, chemokines, complement factors. factors can trigger perpetuate inflammation, causing renal tissue progressive fibrosis. In addition, play critical roles diseases, glucose lipid metabolism, oxidative stress, mitochondrial dysfunction, altered nutrient sensing. Dysregulation contributes progression by inducing tubular injury, apoptosis, Recent studies have provided insights into intricate revealing novel therapeutic targets for prevention treatment Potential strategies modulating through targeting key or inhibiting pro-inflammatory signaling pathways, improving function, nutrient-sensing such as mTOR, AMPK, SIRT1. This review highlights importance potential implications pathways.
Язык: Английский
Процитировано
33
Current Obesity Reports, Год журнала: 2024, Номер 13(4), С. 680 - 702
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
12
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
1
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
1
Archives of Biochemistry and Biophysics, Год журнала: 2024, Номер 755, С. 109986 - 109986
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
4
Clinical Kidney Journal, Год журнала: 2024, Номер 17(9)
Опубликована: Июль 26, 2024
Chronic kidney disease (CKD) is now an unquestionable progressive condition that affects more than 10% of the general population worldwide, and has emerged as one most important causes global mortality. It clear prevalence CKD among aging significantly elevated. involves a broad range complex poorly understood concerns in older adults such frailty, malnutrition, sarcopenia, even cognitive mental dysfunction. In kidneys, renal function glomerular filtration, urine concentration dilution, homeostasis sodium potassium, can be influenced by process. addition, it worth noting end-stage patients often have accompanying activation immune system inflammation, involving both innate adaptive system. Based on this background, review article we attempt to summarize epidemiological characteristics population, discuss immunological mechanisms aging-related CKD, furnish reader with processes for therapy management elderly CKD.
Язык: Английский
Процитировано
4
Nature Reviews Cardiology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 18, 2024
Язык: Английский
Процитировано
4