The intellectual base and global trends in inflammation of diabetic kidney disease: a bibliometric analysis

Renal Failure, Год журнала: 2023, Номер 45(2)

Опубликована: Окт. 23, 2023

Diabetic kidney disease (DKD) is a severe complication of diabetes mellitus (DM). The literature on DKD inflammation research has experienced substantial growth. However, there lack bibliometric analyses. This study aimed to examine the existing in by analyzing articles published Web Science Core Collection (WOSCC) over past 30 years. We conducted visualization analysis using several software, including CiteSpace and VOSviewer. found that growth, indicating rising interest this developing area study. In field, Navarro-Gonzalez, JF most frequently cited author, Kidney International journal, China had highest number publications field inflammation, Monash University emerged as institution with research. primarily centers around investigation 'Glycation end-products', 'chronic disease', 'diabetic nephropathy'. emerging trends will focus 'Gut microbiota', 'NLRP3 inflammasome', 'autophagy', 'pyroptosis', 'sglt2 inhibitor', 'therapeutic target'. Future may further exploring inflammatory response, identifying specific therapeutic targets, studying biomarkers, investigating stem cell therapy tissue engineering, gene editing. summary, examines main areas study, frontiers, which have significant implications for future

Язык: Английский

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Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 4184 - 4184

Опубликована: Фев. 20, 2023

Nod-like receptor protein 3 (NLRP3) is a multi-protein complex belonging to the innate immune system, whose activation by danger stimuli promotes inflammatory cell death. Evidence supports crucial role of NLRP3 inflammasome in transition acute kidney injury Chronic Kidney Disease (CKD), promoting both inflammation and fibrotic processes. Variants pathway-related genes, such as itself CARD8, have been associated with susceptibility different autoimmune diseases. In this study, we investigated for first time association functional variants genes (NLRP3-rs10754558, CARD8-rs2043211), CKD. A cohort transplant recipients, dialysis CKD stage 3–5 patients (303 cases) elderly controls (85 subjects) were genotyped interest compared using logistic regression analyses. Our analysis showed significantly higher G allele frequency variant (67.3%) T CARD8 (70.8%) among cases, control sample (35.9 31.2%, respectively). Logistic regressions significant associations (p < 0.001) between cases. results suggest that rs10754558 rs2043211 could be

Язык: Английский

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Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 3, 2024

Introduction Renal fibrosis associated with inflammation is a critical pathophysiological event in chronic kidney disease (CKD). We have developed DM509 which acts concurrently as farnesoid X receptor agonist and soluble epoxide hydrolase inhibitor investigated efficacy an interventional treatment using the unilateral ureteral obstruction (UUO) mouse model. Methods Male mice went through either UUO or sham surgery. Interventional (10mg/kg/d) was started three days after induction continued for 7 days. Plasma tissue were collected at end of experimental protocol. Results demonstrated marked renal higher hydroxyproline content collagen positive area. reduced by 41% area 65%. evident elevated MCP-1, CD45-positive immune cell infiltration, profibrotic inflammatory gene expression. mice. epithelial-to-mesenchymal transition (EMT) EMT. also had tubular epithelial barrier injury increased KIM-1, NGAL markers 25-50% maintained integrity Vascular 9 to 20-fold ICAM VCAM expression 40-50% treatment. Peritubular vascular density 35% prevented loss. Discussion demonstrating that promising drug combats pathological events progression CKD.

Язык: Английский

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Inflammasome pathway in kidney transplantation

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Ноя. 8, 2023

Kidney transplantation is the best available renal replacement therapy for patients with end-stage kidney disease and associated better quality of life patient survival compared dialysis. However, despite significant technical pharmaceutical advances in this field, transplant recipients are still characterized by reduced long-term graft survival. In fact, almost half lose their allograft after 15–20 years. Most conditions leading to loss triggered activation a large immune-inflammatory machinery. context, several inflammatory markers have been identified, deregulation inflammasome (NLRP3, NLRP1, NLRC4, AIM2), multiprotein complex activated either whole pathogens (including fungi, bacteria, viruses) or host-derived molecules, seems play pivotal pathogenetic role. biological mechanisms developing post-transplant complications (including, ischemia-reperfusion injury, rejections, infections) largely unrecognized, only few research reports, reviewed manuscript, addressed association between abnormal pathway onset/development major clinical effects. Finally, regulation machinery could represent future valuable therapeutic target transplantation.

Язык: Английский

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Pyridazine Derivatives as NLRP3 Inhibitors for Treating Asthma, COPD, Parkinson’s Disease, and Alzheimer’s Disease

ACS Medicinal Chemistry Letters, Год журнала: 2023, Номер 14(8), С. 1047 - 1048

Опубликована: Авг. 1, 2023

Provided herein are novel pyridazine derivatives as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating asthma, COPD, Parkinson's disease, and Alzheimer's processes for preparing compounds.

Язык: Английский

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