Medicine,
Год журнала:
2024,
Номер
103(49), С. e40629 - e40629
Опубликована: Дек. 6, 2024
Numerous
studies
have
substantiated
the
pivotal
role
of
long
non-coding
RNAs
(lncRNAs)
in
progression
non-small
cell
lung
cancer
(NSCLC)
and
prognosis
afflicted
patients.
Notably,
individuals
with
NSCLC
may
exhibit
heightened
vulnerability
to
novel
coronavirus
disease
(COVID-19),
resulting
a
more
unfavorable
subsequent
infection.
Nevertheless,
impact
COVID-19-related
lncRNAs
on
remains
unexplored.
The
aim
our
study
was
develop
an
innovative
model
that
leverages
optimize
Pertinent
genes
patient
data
were
procured
from
reputable
databases,
including
TCGA,
Finngen,
RGD.
Through
co-expression
analysis,
we
identified
associated
COVID-19.
Subsequently,
employed
univariate,
LASSO,
multivariate
COX
regression
techniques
construct
risk
based
these
lncRNAs.
validity
assessed
using
KM
PCA,
ROC.
Furthermore,
functional
enrichment
analysis
conducted
elucidate
pathways
linked
Lastly,
performed
TME
predicted
drug
sensitivity
model.
Based
scores,
patients
categorized
into
high-
low-risk
subgroups,
revealing
distinct
clinicopathological
factors,
immune
pathways,
chemotherapy
between
subgroups.
Four
(AL161431.1,
AC079949.1,
AC123595.1,
AC108136.1)
as
potential
candidates
for
constructing
prognostic
prediction
models
NSCLC.
We
also
observed
positive
correlation
score
MDSC,
exclusion,
CAF.
Additionally,
two
high-risk
subgroups
identified.
Our
findings
further
support
association
COVID-19
infection
neuroactive
ligand-receptor
interaction,
well
steroid
metabolism
Moreover,
several
highly
sensitive
drugs
treatment.
developed
holds
significant
value
predicting
guiding
treatment
decisions.
Gels,
Год журнала:
2024,
Номер
10(7), С. 440 - 440
Опубликована: Июль 1, 2024
Cancer
is
a
highly
heterogeneous
disease
and
remains
global
health
challenge
affecting
millions
of
human
lives
worldwide.
Despite
advancements
in
conventional
treatments
like
surgery,
chemotherapy,
immunotherapy,
the
rise
multidrug
resistance,
tumor
recurrence,
their
severe
side
effects
complex
nature
microenvironment
(TME)
necessitates
innovative
therapeutic
approaches.
Recently,
stimulus-responsive
nanomedicines
designed
to
target
TME
characteristics
(e.g.,
pH
alterations,
redox
conditions,
enzyme
secretion)
have
gained
attention
for
potential
enhance
anticancer
efficacy
while
minimizing
adverse
chemotherapeutics/bioactive
compounds.
Among
various
nanocarriers,
hydrogels
are
intriguing
due
high-water
content,
adjustable
mechanical
characteristics,
responsiveness
external
internal
stimuli,
making
them
promising
candidates
cancer
therapy.
These
properties
make
an
ideal
nanocarrier
controlled
drug
release
within
TME.
This
review
comprehensively
surveys
latest
area
therapy,
exploring
stimuli-responsive
mechanisms,
including
biological
pH,
redox),
chemical
enzymes,
glucose),
physical
temperature,
light),
as
well
dual-
or
multi-stimuli
responsiveness.
Furthermore,
this
addresses
current
developments
challenges
treatment.
Our
aim
provide
readers
with
comprehensive
understanding
treatment,
offering
novel
perspectives
on
development
therapy
other
medical
applications.
World Journal of Biology Pharmacy and Health Sciences,
Год журнала:
2024,
Номер
17(2), С. 068 - 079
Опубликована: Фев. 9, 2024
This
review
provides
a
comprehensive
analysis
of
the
progress
made
in
cancer
research
within
United
States.
Over
past
few
decades,
significant
strides
have
been
taken
to
understand
complexities
cancer,
leading
breakthroughs
diagnostics,
treatment
modalities,
and
overall
patient
care.
The
explores
key
themes,
including
advancements
genomic
medicine,
immunotherapy,
personalized
approaches.
Advancements
medicine
emerged
as
cornerstone
research,
allowing
for
deeper
understanding
genetic
basis
various
cancers.
integration
precision
techniques
has
facilitated
identification
specific
mutations,
paving
way
targeted
therapies
tailored
individual
patients.
Genomic
profiling
not
only
enhanced
diagnostic
accuracy
but
also
provided
valuable
insights
into
heterogeneity,
guiding
researchers
toward
more
effective
strategies.
Immunotherapy
revolutionized
by
harnessing
body's
immune
system
target
eliminate
cells.
delves
remarkable
developing
checkpoint
inhibitors,
adoptive
cell
therapies,
vaccines.
These
innovations
shown
unprecedented
success
treating
previously
challenging
malignancies,
offering
new
hope
patients
with
advanced-stage
concept
is
further
explored,
emphasizing
shift
from
one-size-fits-all
approach
tailoring
treatments
based
on
characteristics.
advent
liquid
biopsies
advanced
imaging
enabled
real-time
monitoring
responses,
facilitating
timely
adjustments
improving
outcomes.
Despite
these
advancements,
acknowledges
persistent
challenges,
such
need
collaboration
between
institutions,
imperative
increased
funding,
importance
addressing
healthcare
disparities
ongoing
commitment
interdisciplinary
translational
initiatives,
patient-centered
emphasized
essential
overcoming
challenges
propelling
field
USA.
In
conclusion,
this
paints
picture
insights,
immunotherapeutic
breakthroughs,
approaches
underscores
promising
future
patients,
while
acknowledging
necessity
continued
efforts
address
existing
propel
even
greater
advancements.
Current Opinion in Biotechnology,
Год журнала:
2024,
Номер
88, С. 103149 - 103149
Опубликована: Май 28, 2024
Single-cell
chemical
and
metabolic
imaging
technologies
provide
unprecedented
insights
into
individual
cell
dynamics,
advancing
our
understanding
of
cellular
processes,
molecular
interactions,
activities.
Advances
in
fluorescence,
Raman,
optoacoustic
(photoacoustic),
or
mass
spectrometry
methods
have
paved
the
way
to
characterize
metabolites,
signaling
molecules,
other
moieties
within
cells.
These
modalities
can
also
lead
single-cell
capabilities
by
targeting
endogenous
contrast
employing
exogenous
generation
techniques,
including
agents
that
target
specific
structure
function.
In
this
review,
we
present
key
developments,
summarize
recent
applications
interrogation
imaging,
illustrate
their
advantages,
limitations,
outlook.
Aging advances.,
Год журнала:
2024,
Номер
1(2), С. 118 - 134
Опубликована: Дек. 1, 2024
Aging
is
a
complex
biological
process
characterized
by
gradual
deterioration
in
physiological
activities,
contributing
to
an
elevated
risk
of
different
age-associated
malignancies,
including
cancer.
The
current
review
paper
aims
elucidate
the
association
between
hallmarks
aging
and
parallel
development
Various
cellular
molecular
mechanisms
underlying
such
as
senescence,
genomic
instability,
telomere
shortening
play
significant
role
accumulation
genetic
mutations
disruption
activities.
It
has
also
discussed
immune
system’s
aging,
indicating
how
age-linked
dysfunction
compromises
body’s
capacity
recognize
eradicate
pre-tumorous
cells,
thus
promoting
cancer
advancement.
This
examines
affects
tumor
microenvironment,
where
age-related
alterations
stromal
extracellular
matrix
factors
lead
conditions
that
promote
growth
proliferation.
Furthermore,
it
discusses
concept
“accelerated
aging”
survivors,
highlighting
negative
effects
its
therapy
intensify
process,
resulting
greater
physical
cognitive
decline.
explores
prospect
new
therapies
target
aging-related
processes
ameliorate
outcomes.
Overall,
underscores
need
for
ongoing
interdisciplinary
research
understand
relationship
cancer,
ultimately
aiming
develop
more
effective
prevention
treatment
approaches.
