Journal of Materials Chemistry B,
Год журнала:
2014,
Номер
2(28), С. 4564 - 4564
Опубликована: Янв. 1, 2014
Fluorescent
carbon
nanodots
(C-dots;
4.3
±
0.8
nm)
from
fresh
tender
ginger
juice
provide
high
suppression
of
the
growth
human
hepatocellular
carcinoma
cells
(HepG2),
with
low
toxicity
to
normal
mammary
epithelial
(MCF-10A)
and
liver
(FL83B).
The
inhibition
is
selective
HepG2
over
other
tested
cancer
cells,
including
lung
cell
line
(A549),
breast
(MDA-MB-231),
cervical
(HeLa).
Western
blot
results
reveal
that
C-dots
up-regulate
expression
p53
protein
only
in
line.
50%
inhibiting
concentration
(IC50)
value
on
0.35
mg
mL-1.
Image
cytometry
show
significant
uptake
by
induce
intracellular
production
reactive
oxygen
species
(ROS,
18.2-fold
increased),
while
remain
almost
same
ROS
levels
after
treatment
(1.11
mL-1).
trigger
pro-apoptotic
factor
promote
apoptosis.
effectively
inhibit
tumors
nude
mice
(104
14
vs.
3.7
0.2
without
within
days).
RSC Advances,
Год журнала:
2015,
Номер
5(35), С. 27986 - 28006
Опубликована: Янв. 1, 2015
The
normal
biochemical
reactions
in
our
body,
increased
exposure
to
the
environment,
and
higher
levels
of
dietary
xenobiotic's
result
generation
reactive
oxygen
species
(ROS)
nitrogen
(RNS).
Chemical Reviews,
Год журнала:
2018,
Номер
118(2), С. 614 - 678
Опубликована: Янв. 16, 2018
Lignin,
a
major
component
of
lignocellulose,
is
the
largest
source
aromatic
building
blocks
on
planet
and
harbors
great
potential
to
serve
as
starting
material
for
production
biobased
products.
Despite
initial
challenges
associated
with
robust
irregular
structure
lignin,
valorization
this
intriguing
biopolymer
has
come
long
way:
recently,
many
creative
strategies
emerged
that
deliver
defined
products
via
catalytic
or
biocatalytic
depolymerization
in
good
yields.
The
purpose
review
provide
insight
into
these
novel
approaches
application
such
emerging
new
structures
synthesis
polymers
pharmacologically
active
molecules.
Existing
functionalization
defunctionalization
lignin-based
compounds
are
also
summarized.
Following
whole
value
chain
from
raw
lignocellulose
through
whenever
possible,
specific
emerge
could
be
future
considered
lignin-derived
platform
chemicals.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2011,
Номер
10(4), С. 221 - 247
Опубликована: Июнь 14, 2011
Abstract:
While
use
of
synthetic
antioxidants
(such
as
butylated
hydroxytoluene
and
hydroxyanisole)
to
maintain
the
quality
ready-to-eat
food
products
has
become
commonplace,
consumer
concern
regarding
their
safety
motivated
industry
seek
natural
alternatives.
Phenolic
can
inhibit
free
radical
formation
and/or
interrupt
propagation
autoxidation.
Fat-soluble
vitamin
E
(α-tocopherol)
water-soluble
C
(L-ascorbic
acid)
are
both
effective
in
appropriate
matrix.
Plant
extracts,
generally
used
for
flavoring
characteristics,
often
have
strong
H-donating
activity
thus
making
them
extremely
antioxidants.
This
antioxidant
is
most
due
phenolic
acids
(gallic,
protocatechuic,
caffeic,
rosmarinic
acids),
diterpenes
(carnosol,
carnosic
acid,
rosmanol,
rosmadial),
flavonoids
(quercetin,
catechin,
naringenin,
kaempferol),
volatile
oils
(eugenol,
carvacrol,
thymol,
menthol).
Some
plant
pigments
(anthocyanin
anthocyanidin)
chelate
metals
donate
H
oxygen
radicals
slowing
oxidation
via
2
mechanisms.
Tea
extracts
grape
seeds
skins
contain
catechins,
epicatechins,
acids,
proanthocyanidins,
resveratrol,
all
which
contribute
antioxidative
activity.
The
objective
this
article
provide
an
overview
antioxidants,
mechanisms
action,
potential
applications.
Molecular Therapy,
Год журнала:
2010,
Номер
18(9), С. 1606 - 1614
Опубликована: Июнь 22, 2010
Monocyte-derived
myeloid
cells
play
vital
roles
in
inflammation-related
autoimmune/inflammatory
diseases
and
cancers.
Here,
we
report
that
exosomes
can
deliver
anti-inflammatory
agents,
such
as
curcumin,
to
activated
vivo.
This
technology
provides
a
means
for
drugs,
target
the
inflammatory
well
overcome
unwanted
off-target
effects
limit
their
utility.
Using
delivery
vehicle,
provide
evidence
curcumin
delivered
by
is
more
stable
highly
concentrated
blood.
We
show
specificity
determined
exosomes,
improvement
of
activity
achieved
directing
associated
with
therapeutic,
but
not
toxic,
effects.
Furthermore,
validate
therapeutic
relevance
this
technique
lipopolysaccharide
(LPS)-induced
septic
shock
mouse
model.
further
lipid
alone,
are
required
enhanced
curcumin.
The
using
drug
carrier
creates
opportunities
treatments
many
without
significant
side
due
innocent
bystander
or
Molecular Therapy,
Год журнала:
2011,
Номер
19(10), С. 1769 - 1779
Опубликована: Сен. 13, 2011
In
this
study,
exosomes
used
to
encapsulate
curcumin
(Exo-cur)
or
a
signal
transducer
and
activator
of
transcription
3
(Stat3)
inhibitor,
i.e.,
JSI124
(Exo-JSI124)
were
delivered
noninvasively
microglia
cells
via
an
intranasal
route.
The
results
generated
from
three
inflammation-mediated
disease
models,
lipopolysaccharide
(LPS)-induced
brain
inflammation
model,
experimental
autoimmune
encephalitis
GL26
tumor
showed
that
mice
treated
intranasally
with
Exo-cur
Exo-JSI124
are
protected
LPS-induced
inflammation,
the
progression
myelin
oligodendrocyte
glycoprotein
(MOG)
peptide
induced
encephalomyelitis
(EAE),
had
significantly
delayed
growth
in
model.
Intranasal
administration
led
rapid
delivery
exosome
encapsulated
drug
was
selectively
taken
up
by
microglial
cells,
subsequently
apoptosis
cells.
Our
demonstrate
strategy
may
provide
noninvasive
novel
therapeutic
approach
for
treating
inflammatory-related
diseases.
Angewandte Chemie International Edition,
Год журнала:
2012,
Номер
51(22), С. 5308 - 5332
Опубликована: Май 4, 2012
Abstract
Turmeric
is
traditionally
used
as
a
spice
and
coloring
in
foods.
It
an
important
ingredient
curry
gives
powder
its
characteristic
yellow
color.
As
consequence
of
intense
color,
turmeric,
or
curcumin
(food
additive
E100),
food
(e.g.
mustard).
contains
the
curcuminoids
curcumin,
demethoxycurcumin,
bisdemethoxycurcumin.
Recently,
health
properties
(neuroprotection,
chemo‐,
cancer
prevention)
have
gained
increasing
attention.
Curcuminoids
induce
endogenous
antioxidant
defense
mechanisms
organism
anti‐inflammatory
activity.
influence
gene
expression
well
epigenetic
mechanisms.
Synthetic
analogues
also
exhibit
biological
This
Review
describes
development
from
“traditional”
to
“modern”
regulator.
Clinical and Experimental Pharmacology and Physiology,
Год журнала:
2011,
Номер
39(3), С. 283 - 299
Опубликована: Ноя. 24, 2011
1.
Curcumin
is
the
active
ingredient
of
dietary
spice
turmeric
and
has
been
consumed
for
medicinal
purposes
thousands
years.
Modern
science
shown
that
curcumin
modulates
various
signalling
molecules,
including
inflammatory
transcription
factors,
enzymes,
protein
kinases,
reductases,
carrier
proteins,
cell
survival
drug
resistance
adhesion
growth
receptors,
cycle
regulatory
chemokines,
DNA,
RNA
metal
ions.
2.
Because
this
polyphenol's
potential
to
modulate
multiple
it
reported
possess
pleiotropic
activities.
First
demonstrated
have
antibacterial
activity
in
1949,
since
anti-inflammatory,
anti-oxidant,
pro-apoptotic,
chemopreventive,
chemotherapeutic,
antiproliferative,
wound
healing,
antinociceptive,
antiparasitic
antimalarial
properties
as
well.
Animal
studies
suggested
may
be
against
a
wide
range
human
diseases,
diabetes,
obesity,
neurological
psychiatric
disorders
cancer,
well
chronic
illnesses
affecting
eyes,
lungs,
liver,
kidneys
gastrointestinal
cardiovascular
systems.
3.
Although
many
clinical
trials
evaluating
safety
efficacy
ailments
already
completed,
others
are
still
ongoing.
Moreover,
used
supplement
several
countries,
India,
Japan,
US,
Thailand,
China,
Korea,
Turkey,
South
Africa,
Nepal
Pakistan.
inexpensive,
apparently
tolerated
potentially
active,
not
approved
treatment
any
disease.
4.
In
present
article,
we
discuss
discovery
key
biological
activities
curcumin,
with
particular
emphasis
on
its
at
molecular
cellular
levels,
animals
humans.
International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(5), С. 1033 - 1033
Опубликована: Фев. 27, 2019
Cancer
is
the
second
leading
cause
of
death
in
world
and
one
major
public
health
problems.
Despite
great
advances
cancer
therapy,
incidence
mortality
rates
remain
high.
Therefore,
quest
for
more
efficient
less
toxic
treatment
strategies
still
at
forefront
current
research.
Curcumin,
active
ingredient
Curcuma
longa
plant,
has
received
attention
over
past
two
decades
as
an
antioxidant,
anti-inflammatory,
anticancer
agent.
In
this
review,
a
summary
medicinal
chemistry
pharmacology
curcumin
its
derivatives
regard
to
activity,
their
main
mechanisms
action,
cellular
targets
been
provided
based
on
literature
data
from
experimental
clinical
evaluation
cell
lines,
animal
models,
human
subjects.
addition,
recent
drug
delivery
systems
cells
have
highlighted.
