Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

Journal of the Science of Food and Agriculture, Год журнала: 2021, Номер 101(14), С. 5747 - 5762

Опубликована: Июнь 18, 2021

Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as an aromatic stimulant, food preservative, coloring material. The commonly used names of turmeric are castor saffron, turmeric, saffron root. yellow-orange polyphenolic natural substance derived from C. rhizomes. It has been to treat common inflammatory diseases, tumors, biliary anorexia, cough, topical wounds, diabetic injuries, liver disorders, rheumatism, sinusitis. Extensive studies on the biological properties pharmacological consequences extracts have conducted recent years. Curcumin, primary yellow biocomponent anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic, antibacterial, antiprotozoal, antiviral, antifibrotic, immunomodulatory, antifungal properties. Defense assessment tests showed that curcumin tolerated well at high doses, without adverse effects. Thus, highly active material with potential different diseases modern medicine. This review article focuses curcumin's characteristics. most popular methods for encapsulation also discussed. Several effective techniques approaches proposed curcuminoid capsulation, including nanocomplexing, gelation, complex coacervation, electrospraying, solvent-free pH-driven encapsulation. highlights chemical properties, allowing readers expand their perspectives its use development functional products health-promoting © 2021 Society Chemical Industry.

Язык: Английский

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Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability

Molecules, Год журнала: 2020, Номер 25(12), С. 2791 - 2791

Опубликована: Июнь 17, 2020

Curcumin is a bioactive constituent isolated from turmeric that has historically been used as seasoning, pigment, and herbal medicine in food. Recently, it become one of the most commonly studied nutraceuticals pharmaceutical, supplement, food areas because its myriad potential health benefits. For instance, claimed to exhibit antioxidant, anti-inflammatory, antimicrobial, antiparasite, anticancer activities when ingested drug, or Toxicity studies suggest safe consume, even at relatively high levels. Its broad-spectrum biological low toxicity have meant widely explored nutraceutical ingredient for application functional foods. However, there are several hurdles formulators must overcome incorporating curcumin into commercial products, such water solubility (especially under acidic neutral conditions), chemical instability alkaline rapid metabolism by enzymes human body, limited bioavailability. As result, only small fraction actually absorbed bloodstream. These can be least partially using encapsulation technologies, which involve trapping within particles. Some edible microparticles nanoparticles utilized this purpose micelles, liposomes, emulsions, solid lipid particles, biopolymer Each these technologies own benefits limitations particular product applications important select appropriate one.

Язык: Английский

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Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

Nano Today, Год журнала: 2021, Номер 38, С. 101119 - 101119

Опубликована: Март 12, 2021

Язык: Английский

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Curcumin induces ferroptosis in non‐small‐cell lung cancer via activating autophagy

Thoracic Cancer, Год журнала: 2021, Номер 12(8), С. 1219 - 1230

Опубликована: Март 3, 2021

Abstract Background Emerging studies showed curcumin can inhibit glioblastoma and breast cancer cells via regulating ferroptosis. However, the role of ferroptosis in inhibitory effect on non‐small‐cell lung (NSCLC) remains unclear. Methods Cell counting kit‐8 (CCK‐8) assay was used to measure viability A549 H1299 under different conditions. proliferation examined by Ki67 immunofluorescence. The morphological changes tumor tissues were observed optical microscope hematoxylin eosin (H&E) staining. Intracellular reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), iron contents determined corresponding kit. related protein expression levels detected western blot immunohistochemistry. Transmission electron observe ultrastructure cells. Results Curcumin inhibited growth cell proliferation, but promoted death. Characteristic group, including overload, GSH depletion lipid peroxidation. Meanwhile, level ACSL4 higher SLC7A11 GPX4 lower group than that control group. Incubation inhibitors ferrostatin‐1 (Fer‐1) or knockdown iron‐responsive element‐binding 2 (IREB2) notably weakened curcumin‐induced anti‐tumor Further investigation suggested induced mitochondrial membrane rupture cristae decrease, increased autolysosome, Beclin1 LC3, decreased P62. Curcumin‐induced autophagy subsequent both alleviated with inhibitor chloroquine (CQ) siBeclin1. Conclusion activating NSCLC, which enhanced therapeutic NSCLC.

Язык: Английский

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Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Pharmaceutics, Год журнала: 2021, Номер 13(10), С. 1715 - 1715

Опубликована: Окт. 17, 2021

Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to use this compound. Poor absorption, fast metabolism, rapid systemic clearance are most important factors contributing low curcumin levels in plasma tissues. Accordingly, overcome these issues, numerous strategies have been proposed investigated article. Due advances field, we describe here promising for increasing including adjuvant, complexed/encapsulated curcumin, specific formulations, nanoparticles. We analyze current strategies, already available market, advanced technologies that can offer future perspective effective formulations. focus attention on effectiveness curcumin-based formulations clinical trials, providing comprehensive summary. Clinical trial results, employing various methods showed improved bioavailability corresponds increased therapeutic efficacy. Furthermore, field nanoparticles hold great promise developing complexes as agents. Summarizing, suitable polyphenol will ensure possibility using curcumin-derived practice preventive disease-modifying therapeutics.

Язык: Английский

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The biology of ergothioneine, an antioxidant nutraceutical

Nutrition Research Reviews, Год журнала: 2020, Номер 33(2), С. 190 - 217

Опубликована: Фев. 13, 2020

Abstract Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but not plants animals who acquire it via the soil their diet, respectively. Animals have evolved highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) humans, signifying its importance, ERG may even status vitamin. accumulates differentially various tissues, according to expression SLC22A4, favouring those such erythrocytes be subject oxidative stress. Mushroom or consumption seems provide significant prevention against stress large systems. strong cytoprotective status, concentration lowered number chronic inflammatory diseases. been passed safe regulatory agencies, value nutraceutical more generally.

Язык: Английский

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Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy

Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2020, Номер 45, С. 100384 - 100384

Опубликована: Сен. 9, 2020

Язык: Английский

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Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1532 - 1532

Опубликована: Янв. 28, 2022

Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, oxaliplatin, have been widely used to treat a multitude of human cancers. However, considerable proportion patients often relapse due drug resistance and/or toxicity multiple organs including the liver, kidneys, gastrointestinal tract, cardiovascular, hematologic, nervous systems. In this study, we sought provide comprehensive review current state science highlighting use cisplatin in cancer therapy, with special emphasis on its molecular mechanisms action, treatment modalities combination therapy natural products. Hence, searched literature using various scientific databases., MEDLINE, PubMed, Google Scholar, relevant sources, collect publications cisplatin, products, uses treatment, modes therapeutic strategies. Our search results revealed that new strategic approaches for evaluated some degree success. Scientific evidence from both vitro vivo studies demonstrates many medicinal plants contain bioactive compounds are promising candidates diseases, therefore represent an excellent source discovery. preclinical studies, it has demonstrated products not only enhance activity but also attenuate chemotherapy-induced toxicity. Many experimental reported exert their action by triggering apoptosis through modulation mitogen-activated protein kinase (MAPK) p53 signal transduction pathways enhancement chemosensitivity. Furthermore, protect against cisplatin-induced organ modulating several gene transcription factors inducing cell death necrosis. addition, formulations polymeric, lipid, inorganic, carbon-based nano-drug delivery systems found delay release, prolong half-life, reduce systemic while formulations, nanocapsules, nanogels, hydrogels, penetration, target cells, inhibit tumor progression.

Язык: Английский

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The Role of Curcumin in Cancer Treatment

Biomedicines, Год журнала: 2021, Номер 9(9), С. 1086 - 1086

Опубликована: Авг. 26, 2021

Curcumin is a polyphenol extracted from the rhizomes of turmeric plant, Curcuma longa which has anti-inflammatory, and anticancer properties. Chronic inflammation associated with development cancer. acts on regulation various immune modulators, including cytokines, cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), partly explains its effects. It also takes part in downregulation growth factors, protein kinases, oncogenic molecules signaling pathways, such as nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), c-Jun N-terminal kinase (JNK) signal transducer activator transcription 3 (STAT3) signaling. Clinical trials curcumin have been completed or are ongoing for types This review presents molecular mechanisms different cancer evidence most recent clinical trials.

Язык: Английский

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Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers

Biomolecules, Год журнала: 2021, Номер 11(3), С. 392 - 392

Опубликована: Март 7, 2021

Cancer is a major burden of disease globally. Each year, tens millions people are diagnosed with cancer worldwide, and more than half the patients eventually die from it. Significant advances have been noticed in treatment, but mortality incidence rates cancers still high. Thus, there growing research interest developing effective less toxic treatment approaches. Curcumin (CUR), active component turmeric (Curcuma longa L.), has gained great as an antioxidant, anticancer, anti-inflammatory agent. This natural compound shows its anticancer effect through several pathways including interfering multiple cellular mechanisms inhibiting/inducing generation cytokines, enzymes, or growth factors IκB kinase β (IκKβ), tumor necrosis factor-alpha (TNF-α), signal transducer, activator transcription 3 (STAT3), cyclooxygenase II (COX-2), protein D1 (PKD1), nuclear factor-kappa B (NF-κB), epidermal factor, mitogen-activated (MAPK). Interestingly, activity CUR limited primarily due to poor water solubility, which can lead low chemical stability, oral bioavailability, uptake. Delivering drugs at controlled rate, slow delivery, targeted delivery other very attractive methods pursued vigorously. Multiple nanoformulations also developed so far ameliorate solubility bioavailability provide protection against hydrolysis inactivation. In this review, we summarized cancers, for example, gastrointestinal, head neck, brain, pancreatic, colorectal, breast, prostate cancers. addition, focused on findings obtained experimental clinical studies regarding animal models, human subjects, cell lines.

Язык: Английский

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