Classification of Metal-Based Drugs according to Their Mechanisms of Action

Chem, Год журнала: 2019, Номер 6(1), С. 41 - 60

Опубликована: Ноя. 7, 2019

Язык: Английский

---

Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention

Cancer Prevention Research, Год журнала: 2011, Номер 4(8), С. 1158 - 1171

Опубликована: Май 6, 2011

Abstract Since ancient times, chemopreventive agents have been used to treat/prevent several diseases including cancer. They are found elicit a spectrum of potent responses anti-inflammatory, antioxidant, antiproliferative, anticarcinogenic, and antiangiogenic activity in various cell cultures some animal studies. Research over the past 4 decades has shown that chemopreventives affect number proteins involved molecular pathways regulate inflammatory carcinogenic cell. Various enzymes, transcription factors, receptors, adhesion also affected by chemopreventives. Although, these natural compounds significant efficacy culture studies, they elicited limited clinical Their introduction into setting is hindered largely their poor solubility, rapid metabolism, or combination both, ultimately resulting bioavailability upon oral administration. Therefore, circumvent limitations ease transition clinics, alternate strategies should be explored. Drug delivery systems such as nanoparticles, liposomes, microemulsions, polymeric implantable devices emerging one viable alternatives deliver therapeutic concentrations curcumin, ellagic acid, green tea polyphenols, resveratrol systemic circulation. In this review article, we attempted provide comprehensive outlook for approaches, using curcumin model agent, discussed future enable highly physician's armamentarium. Cancer Prev Res; 4(8); 1158–71. ©2011 AACR.

Язык: Английский

---

Curcumin and Diabetes: A Systematic Review

Evidence-based Complementary and Alternative Medicine, Год журнала: 2013, Номер 2013, С. 1 - 16

Опубликована: Янв. 1, 2013

Turmeric ( Curcuma longa ), a rhizomatous herbaceous perennial plant of the ginger family, has been used for treatment diabetes in Ayurvedic and traditional Chinese medicine. The active component turmeric, curcumin, caught attention as potential its complications primarily because it is relatively safe inexpensive drug that reduces glycemia hyperlipidemia rodent models diabetes. Here, we review recent literature on applications curcumin diabetes-related liver disorders, adipocyte dysfunction, neuropathy, nephropathy, vascular diseases, pancreatic other complications, also discuss antioxidant anti-inflammatory properties. additional curcuminoid compounds prevention are included this paper. Finally, mention approaches currently being sought to generate “super curcumin” through improvement bioavailability bring promising natural product forefront therapeutics.

Язык: Английский

---

Comparative Absorption of a Standardized Curcuminoid Mixture and Its Lecithin Formulation

Journal of Natural Products, Год журнала: 2011, Номер 74(4), С. 664 - 669

Опубликована: Март 17, 2011

The relative absorption of a standardized curcuminoid mixture and its corresponding lecithin formulation (Meriva) was investigated in randomized, double-blind, crossover human study. Clinically validated dosages were used for both products, plasma levels all three major curcuminoids [curcumin (1a), demethoxycurcumin (1b), bisdemethoxycurcumin (1c)] evaluated. Total about 29-fold higher Meriva than unformulated mixture, but only phase-2 metabolites could be detected, concentrations still significantly lower those required the inhibition most anti-inflammatory targets curcumin. Remarkably, phospholipid increased demethoxylated much more that curcumin with significant differences profile between mixture. Thus, after administration not potent analogue many vitro assays. improved absorption, possibly also better profile, might underlie clinical efficacy at doses mixtures.

Язык: Английский

---

Carbon dots prepared from ginger exhibiting efficient inhibition of human hepatocellular carcinoma cells

Journal of Materials Chemistry B, Год журнала: 2014, Номер 2(28), С. 4564 - 4564

Опубликована: Янв. 1, 2014

Fluorescent carbon nanodots (C-dots; 4.3 ± 0.8 nm) from fresh tender ginger juice provide high suppression of the growth human hepatocellular carcinoma cells (HepG2), with low toxicity to normal mammary epithelial (MCF-10A) and liver (FL83B). The inhibition is selective HepG2 over other tested cancer cells, including lung cell line (A549), breast (MDA-MB-231), cervical (HeLa). Western blot results reveal that C-dots up-regulate expression p53 protein only in line. 50% inhibiting concentration (IC50) value on 0.35 mg mL-1. Image cytometry show significant uptake by induce intracellular production reactive oxygen species (ROS, 18.2-fold increased), while remain almost same ROS levels after treatment (1.11 mL-1). trigger pro-apoptotic factor promote apoptosis. effectively inhibit tumors nude mice (104 14 vs. 3.7 0.2 without within days).

Язык: Английский

---