European Journal of Inflammation,
Год журнала:
2023,
Номер
21
Опубликована: Июнь 1, 2023
Heart
failure
(HF)
is
a
complicated
clinical
syndrome
caused
by
abnormal
cardiac
structure
and/or
function,
leading
to
ventricular
filling
ejection
dysfunction.
Pyroptosis
newly
identified
form
of
programmed
cell
death
often
accompanied
inflammation
during
HF.
The
NLRP3
inflammasome,
acting
as
caspase-1
activation
platform,
plays
critical
role
in
the
production
key
pro-inflammatory
cytokines
and
pyroptosis.
Therefore,
inflammasomes
are
involved
pathophysiological
process
Our
paper
will
review
latest
research
progress
on
relationship
among
pyroptosis,
inflammasomes,
Cell Stress and Chaperones,
Год журнала:
2024,
Номер
29(1), С. 158 - 174
Опубликована: Янв. 29, 2024
The
endoplasmic
reticulum
(ER)
plays
a
vital
function
in
maintaining
cellular
homeostasis.
Endoplasmic
stress
(ERS)
can
trigger
various
modes
of
cell
death
by
activating
the
unfolded
protein
response
(UPR)
signaling
pathway.
Cell
crucial
role
occurrence
and
development
diseases
such
as
cancer,
liver
diseases,
neurological
cardiovascular
diseases.
Several
including
hypertension,
atherosclerosis,
heart
failure
are
associated
with
ER
stress.
stress-mediated
is
interest
disease.
Moreover,
an
increasing
body
evidence
supports
potential
modulating
ERS
for
treating
This
paper
provides
comprehensive
review
UPR
pathway,
mechanisms
that
induce
death,
Additionally,
we
discuss
common
along
therapeutic
strategies.
International Reviews of Immunology,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Янв. 3, 2025
Heart
failure
(HF)
causes
structural
and
functional
changes
in
the
heart,
with
pyroptosis-mediated
inflammatory
response
as
core
link
HF
pathogenesis.
E3
ubiquitin
ligases
participate
cardiovascular
disease
progression.
Here,
we
explored
underlying
molecular
mechanisms
of
ligase
Smurf1
governing
HF.
Abstract
Myocardial
remodeling
is
a
crucial
pathophysiological
factor
underlying
heart
failure,
the
leading
cause
of
death
globally.
In
this
study,
we
utilized
confocal
Raman
spectroscopy
imaging
to
gain
unprecedented
insights
into
myocardial
tissue
during
remodeling.
We
induced
in
rats
via
subcutaneous
administration
isoproterenol
(ISO)
(5
mg/kg)
over
seven
days,
meticulously
validated
by
echocardiography
and
histopathological
staining.
Subsequent
analyses
using
transmission
electron
microscopy
revealed
significant
mitochondrial
damage.
Confocal
imaging,
however,
provided
most
detailed
visualization
complex
architecture
within
remodeled
tissue.
Notably,
technique
enabled
precise
differentiation
between
hypertrophic
fibrotic
regions
myocardium.
These
findings
not
only
deepen
our
understanding
mechanisms
driving
but
also
highlight
transformative
potential
as
label‐free,
high‐resolution
tool
for
assessing
cardiac
pathology.
Additionally,
artificial
intelligence
(AI)
assisted
identification
rapid
sites
tissues
further
enhance
technology
targeted
clinical
applications,
marking
advancement
managing
failure.
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 5, 2024
Cell
death
is
an
essential
cellular
mechanism
that
ensures
quality
control
and
whole-body
homeostasis.
Various
modes
of
cell
have
been
studied
detailed.
Unbalanced
can
lead
to
uncontrolled
proliferation
(i.e.,
tumors)
or
excessive
loss
cells
ischemia
injury
tissue
loss).
Thus,
it
imperative
for
be
balanced
controlled.
Here,
we
will
focus
on
a
recent
mode
called
pyroptosis.
While
extensive
studies
shown
the
role
this
route
in
macrophages
monocytes,
evidence
pyroptosis
expanded
encompass
other
pathologies,
including
cancer
cardiac
diseases.
Herein,
provide
brief
review
discuss
current
gaps
knowledge
scientific
advances
years.
Lastly,
conclusions
prospective
relevance
various
Objective
This
study
aimed
to
explore
the
serum
levels
of
gasdermin
D
(GSDMD)
in
uremic
(end-stage
kidney
disease,
ESKD)
patients
and
their
correlation
with
vascular
calcification
(VC)
clinical
results.
Journal of Cellular Biochemistry,
Год журнала:
2023,
Номер
124(6), С. 785 - 796
Опубликована: Май 14, 2023
Exosomes
are
membrane-surrounded
extracellular
vesicles
released
by
almost
all
cell
types,
which
mediate
intercellular
communications
delivering
bioactive
molecules
from
secretory
cells
to
recipient
cells.
Long
noncoding
RNAs
(lncRNAs)
a
large
class
of
non-(protein)-coding
with
lengths
exceeding
200
nucleotides
that
very
active
in
the
development
cardiovascular
diseases
(CVDs).
Increasing
evidence
suggests
exosomal
lncRNAs
also
play
important
roles
progress
CVDs.
We
focus
on
current
available
studies
regarding
these
secreted
and
absorbed
cardiomyocytes
their
functional
CVDs,
hopefully
providing
basis
for
deeper
understanding
pathological
mechanisms
CVDs
potential
clinical
diagnosis
therapy.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 13, 2023
Evidence
from
clinical
research
and
animal
studies
indicates
that
inflammation
is
an
important
factor
in
the
occurrence
development
of
cardiovascular
disease
(CVD).
Emerging
evidence
shows
nucleic
acids
serve
as
crucial
pathogen-associated
molecular
patterns
(PAMPs)
or
non-infectious
damage-associated
(DAMPs),
are
released
then
recognized
by
pattern
recognition
receptors
(PRRs),
which
activates
immunological
signaling
pathways
for
host
defense.
Mechanistically,
activate
cyclic
GMP-AMP
synthase
(cGAS)
its
downstream
receptor
stimulator
interferon
genes
(STING)
to
promote
type
I
interferons
(IFNs)
production,
play
regulatory
function
during
initiation
innate
immune
response
various
diseases,
including
CVD.
This
pathway
represents
essential
defense
mechanism
organism’s
system.
In
this
review,
we
outline
overall
profile
cGAS-STING
signaling,
summarize
latest
findings
on
acid
release
trafficking,
discuss
their
potential
role
review
also
sheds
light
directions
future
investigations
