Importance of long non-coding RNAs in the pathogenesis, diagnosis, and treatment of myocardial infarction
IJC Heart & Vasculature,
Год журнала:
2024,
Номер
55, С. 101529 - 101529
Опубликована: Окт. 17, 2024
Язык: Английский
Cardioprotective Effects of hUCMSCs-Exosi-EGR1 MN Patch in MI/RI by Modulating Oxidative Stress and Mitophagy
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101500 - 101500
Опубликована: Янв. 19, 2025
In
an
effort
to
address
the
detrimental
effects
of
myocardial
ischemia/reperfusion
injury
(MI/RI),
this
study
introduces
a
novel
therapeutic
strategy
that
involves
microneedle
(MN)
patch
loaded
with
exosomes
derived
from
human
umbilical
cord
mesenchymal
stem
cells
(hUCMSCs)
and
carrying
small
interfering
RNA
(siRNA)
targeting
early
growth
response-1
(EGR1).
By
delivering
hUCMSCs-derived
containing
EGR1
siRNA
(hUCMSCs-Exosi-EGR1),
MN
demonstrated
promising
cardioprotective
in
both
vitro
vivo
models
MI/RI.
The
results
highlighted
efficacy
Exosi-EGR1
enhancing
cardiomyocyte
viability,
attenuating
oxidative
stress
levels,
fostering
mitophagy
regulation.
Moreover,
exhibited
excellent
mechanical
properties
sustained
drug
release
characteristics
when
embedded
Gelatin
methacryloyl
(GelMA)
matrix.
Noteworthy
outcomes
experiments
included
significant
improvements
cardiac
function,
reduced
fibrosis,
decreased
apoptosis
rates
MI/RI
mice,
emphasizing
potential
value
mitigating
through
modulation
mechanisms.
Язык: Английский
miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection
Archives of Microbiology,
Год журнала:
2023,
Номер
205(8)
Опубликована: Июль 21, 2023
Язык: Английский
Roles of extracellular vesicles derived from healthy and obese adipose tissue in inter-organ crosstalk and potential clinical implication
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 29, 2024
Extracellular
vesicles
(EVs)
are
nanovesicles
containing
bioactive
molecules
including
proteins,
nucleic
acids
and
lipids
that
mediate
intercellular
inter-organ
communications,
holding
promise
as
potential
therapeutics
for
multiple
diseases.
Adipose
tissue
(AT)
serves
a
dynamically
distributed
energy
storage
organ
throughout
the
body,
whose
accumulation
leads
to
obesity,
condition
characterized
by
infiltration
with
abundant
immune
cells.
Emerging
evidence
has
illustrated
EVs
secreted
AT
novel
class
of
adipokines
regulate
homeostasis
between
peripheral
organs.
However,
most
studies
focused
on
investigations
derived
from
adipocytes
or
adipose-derived
stem
cells
(ADSCs),
summarization
functions
in
cellular
crosstalk
directly
adipose
(AT-EVs)
still
limited.
Here,
we
provide
systemic
summary
key
components
healthy
tissue,
showing
their
significance
recovery
metabolic
regulation.
Also,
discuss
harmful
influences
obese
distal
Furthermore,
elucidate
applications
constraints
patients
lipoaspirates
therapeutic
agents,
highlighting
AT-EVs
valuable
biological
material
broad
prospects
future
clinical
use.
Язык: Английский
Genetics in the diagnosis and treatment of cardiovascular diseases
Journal of Translational Genetics and Genomics,
Год журнала:
2024,
Номер
8(2), С. 186 - 206
Опубликована: Апрель 15, 2024
Cardiovascular
diseases
(CVDs)
remain
one
of
the
leading
causes
morbidity
and
mortality
worldwide,
with
genetics
being
a
major
risk
factor.
Genetic
cardiovascular
disease
can
occur
either
because
single
variant
(Mendelian)
or
polygenic
influences
has
been
linked
to
inherited
conditions
(ICC)
such
as
arrhythmias,
cardiomyopathies,
dyslipidemias,
aortopathies
which
are
significant
factors
sudden
cardiac
death
in
young
adults.
Timely
screening,
diagnosis,
management
ICC
not
only
provide
life-saving
treatment
patient,
but
also
identify
at-risk
family
members.
The
field
pharmacogenomics
(PGx)
helped
understand
variable
action
medications
clopidogrel,
aspirin,
warfarin,
statin
according
genotype.
Newer
technologies
multi-omics
combine
data
from
multiple
sources
genomics,
epigenomics,
transcriptomics,
proteomics,
metabolomics,
microbiome.
These
advancements
contribute
development
prediction
scores
precision
medicine
tailored
individual
genotypes.
Substantial
strides
have
made
genetic-based
therapeutics,
gene
editing
technologies,
drug
delivery
systems,
significantly
expanded
options
for
patients
acquired
CVDs.
Although
variable,
country-
society-specific
guidelines
on
genetic
testing
PGx
continuously
updated
keep
up
ongoing
research
field.
Along
appropriate
knowledge,
other
including
cost
availability
play
vital
role
usage
by
both
physicians
patients.
With
advent
newer
CVDs,
key
factor
is
counselors
(GCs)
who
specifically
trained
genomics.
current
review
provides
concise
summary
diagnosis
Язык: Английский