The Intersections between Neuroscience and Medulloblastoma

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217660 - 217660

Опубликована: Март 1, 2025

Язык: Английский

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Multifocal medulloblastoma in an adult: a case report and review of the literature

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Background: Medulloblastoma (MB) is a highly aggressive tumor originating in the cerebellum, predominantly affecting children. Adult medulloblastoma rare, leading to lack of standardized treatment protocol. Although multimodal strategies from pediatric MB have improved outcomes adult patients, challenges persist, including early diagnosis difficulties, toxicity, recurrence risks, targeted therapies, and controversies over chemotherapy timing regimen. Case Description: We present clinical case involving 53-year-old male patient diagnosed with multifocal medulloblastoma, who presented symptoms dizziness. Cranial magnetic resonance imaging (MRI) revealed space-occupying lesions right cerebellar infratentorial region temporal pole, which were initially suspected be meningiomas. The subsequently underwent surgical resection subtentorial lesion, was pathologically confirmed medulloblastoma. Molecular classification through genetic testing classified it as SHH subtype. Postoperatively, received sequential radiotherapy chemotherapy. After radiotherapy, lesion pole disappeared, recovered well. Disease-free survival this more than 2 years, during returned hospital for follow-up every three months. Currently, good condition no significant sequelae or signs recurrence. Conclusion: even rarer. we report surgery followed by chemotherapy, resulting favorable prognosis. This may suggest that postoperative combined could effective controlling

Язык: Английский

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Multifocal medulloblastoma in an adult: a case report and review of the literature

Journal of Cancer Research and Clinical Oncology, Год журнала: 2025, Номер 151(5)

Опубликована: Май 15, 2025

Язык: Английский

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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

Cancer Cell, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Clinical advances in analytical profiling of signature lipids: implications for severe non-communicable and neurodegenerative diseases

Metabolomics, Год журнала: 2024, Номер 20(2)

Опубликована: Март 8, 2024

Язык: Английский

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Overcoming Treatment Resistance in Medulloblastoma: Underlying Mechanisms and Potential Strategies

Cancers, Год журнала: 2024, Номер 16(12), С. 2249 - 2249

Опубликована: Июнь 18, 2024

Medulloblastoma is the most frequently encountered malignant brain tumor in pediatric population. The standard of care currently consists surgical resection, craniospinal irradiation, and multi-agent chemotherapy. However, despite this combination multiple aggressive modalities, recurrence disease remains a substantial concern, treatment resistance rising issue. development results from interplay myriad anatomical properties, cellular processes, molecular pathways, genetic epigenetic alterations. In fact, several efforts have been directed towards domain characterizing major contributors to resistance. Herein, review highlights different mechanisms that drive relapse are implicated occurrence discusses them context latest molecular-based classification medulloblastoma. These include impermeability blood-brain barrier drugs, overactivation specific resistant multipotent nature cancer stem cells, intratumoral intertumoral heterogeneity, metabolic plasticity. Subsequently, we build on explore potential strategies targeted agents can abrogate these mechanisms, undermine resistance, augment medulloblastoma’s response therapeutic modalities.

Язык: Английский

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A preface to the special issue “Pediatric tumors”

Biochemical Pharmacology, Год журнала: 2023, Номер 217, С. 115844 - 115844

Опубликована: Окт. 4, 2023

Язык: Английский

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