Effects of Treatment on Structural and Functional Parameters of the Left Heart in Naïve Acromegaly Patients: Prospective Single-Centre Study: 12-Month Follow-Up

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(10), С. 3397 - 3397

Опубликована: Май 13, 2025

Background/Objectives: Cardiovascular diseases are the most prevalent comorbidities in patients with acromegaly (APs). Acromegalic cardiomyopathy is leading cause of mortality APs. This study aimed to assess changes morphology and function left heart naïve APs 12 months after beginning treatment explore effects disease activity body composition parameters on heart. Methods: prospective involved 34 healthy controls (CON) matched for age, gender, BMI. DXA 2D echocardiography were performed at diagnosis treatment. Results: In APs, prevalence ventricular (LV) hypertrophy was 70%. LV mass index (LVMI) greater compared CON (124 vs. 86 ± g/m2, p < 0.001), but no difference size systolic LV. presented increased atrium volume (LAVI) diastolic dysfunction Twelve treatment, IGF-1 levels decreased significantly (p biochemical control achieved 73.52% We found that all LAVI LVMI (all 0.05), improved without function. multiple analyses, surface area (β = -0.444, 0.001) lean -0.298, 0.027) independent predictors reverse remodelling Conclusions: confirmed reversal structure, followed by an improvement

Язык: Английский

---

Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease

npj Metabolic Health and Disease, Год журнала: 2024, Номер 2(1)

Опубликована: Ноя. 29, 2024

Adipose tissue depots develop specific functions in a location dependent manner. In humans, this for example includes thermogenic capacity the brown adipose supraclavicular, deep neck and perirenal depots, healthy lipid storage primarily gluteofemoral subcutaneous depot, immunogenic support visceral omental depot. These distinct are at some point programmed into progenitor cells, which retain of phenotype from depot they originated upon isolation differentiation vitro. Cardiometabolic diseases associate with body fat distribution, an accumulation lipids accompanied by low grade inflammation insulin resistance as typical phenotype. However, well-functioning contribute to metabolically phenotype, it is therefore worth understanding function regulation these adipocytes. review, we will discuss dysregulations human associated cardiometabolic disease, consequences has on whole metabolism, how depot-specific might affect other progress disease condition.

Язык: Английский

---

The Effects of Body Cold Exposure (Cryolipolysis) on Fat Mass and Plasma Cholesterol

Life, Год журнала: 2024, Номер 14(9), С. 1082 - 1082

Опубликована: Авг. 29, 2024

This study investigates the impact of cryolipolysis on reducing localized fat and altering plasma lipid profiles in 30 overweight obese women. Conducted at Health Technology Laboratory Evangelical University Goiás, this clinical research adhered to stringent ethical guidelines.

Язык: Английский

---

[Association Between Triglyceride Glucose Index and Triglyceride Glucose-Obesity Composite Indices and the Risk of Ischemic Heart Disease].

PubMed, Год журнала: 2024, Номер 55(5), С. 1123 - 1132

Опубликована: Сен. 20, 2024

To explore the association between triglyceride-glucose index (TyG) and TyG-obesity composite indices, including TyG-waist circumference (TyG-WC), TyG-body mass (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), risk of ischemic heart disease (IHD), to provide reference for prevention IHD.

Язык: Английский

---