Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease

npj Metabolic Health and Disease, Journal Year: 2024, Volume and Issue: 2(1)

Published: Nov. 29, 2024

Adipose tissue depots develop specific functions in a location dependent manner. In humans, this for example includes thermogenic capacity the brown adipose supraclavicular, deep neck and perirenal depots, healthy lipid storage primarily gluteofemoral subcutaneous depot, immunogenic support visceral omental depot. These distinct are at some point programmed into progenitor cells, which retain of phenotype from depot they originated upon isolation differentiation vitro. Cardiometabolic diseases associate with body fat distribution, an accumulation lipids accompanied by low grade inflammation insulin resistance as typical phenotype. However, well-functioning contribute to metabolically phenotype, it is therefore worth understanding function regulation these adipocytes. review, we will discuss dysregulations human associated cardiometabolic disease, consequences has on whole metabolism, how depot-specific might affect other progress disease condition.

Language: Английский

[Association Between Triglyceride Glucose Index and Triglyceride Glucose-Obesity Composite Indices and the Risk of Ischemic Heart Disease].

PubMed, Journal Year: 2024, Volume and Issue: 55(5), P. 1123 - 1132

Published: Sept. 20, 2024

To explore the association between triglyceride-glucose index (TyG) and TyG-obesity composite indices, including TyG-waist circumference (TyG-WC), TyG-body mass (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), risk of ischemic heart disease (IHD), to provide reference for prevention IHD.

Language: Английский