BMC Endocrine Disorders,
Год журнала:
2023,
Номер
23(1)
Опубликована: Янв. 9, 2023
Both
age
and
gender
are
the
influence
factors
of
hemoglobin
concentration.
However,
changing
trend
levels
between
males
females
with
remains
unclear.
This
study
aimed
to
explore
their
characteristics
in
different
genders.A
cross-sectional
was
conducted
Physical
Examination
Center
First
Affiliated
Hospital
Wannan
Medical
College
Wuhu,
China
from
2014
2016.
The
generalized
linear
model
applied
relationship
age,
levels.Among
303,084
participants,
mean
for
46.9
±
13.4(15-98)
48.1
13.7(14-98)
years
old,
respectively.
Generalized
smoothing
splines
showed
that
increased
up
25
then
decreased
men;
women
until
20,
decreased,
slight
increase
again
(β
=
0.244,
P
<
0.01).
After
dividing
all
participants
into
hyperglycemia
normal
groups,
only
female
group
a
significant
upward
0.257,
0.01)
ages
50-59.Hemoglobin
concentration
changes
curve
is
females.
slightly
range
50-59
old
should
be
considered
developing
reference
making.
Frontiers in Pediatrics,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 11, 2024
Introduction
Down
syndrome
(DS)
is
linked
to
unique
hematopoietic
characteristics
that
affect
complete
blood
count
(CBC)
parameters.
Accurate
reference
ranges
are
essential
for
proper
CBC
interpretation
in
this
population.
Methods
This
retrospective
study
analyzed
2,627
CBCs
from
481
DS
patients,
aged
31
days
18
years,
at
a
tertiary
care
center
Italy.
Patients
with
significant
comorbidities
were
excluded
ensure
homogeneous
group.
Results
parameters
assessed
establish
age-
and
sex-specific
ranges.
Centile
charts
developed
each
parameter,
an
online
tool
was
created
allow
clinicians
compare
individual
results
the
new
Comparisons
general
pediatric
population
revealed
differences,
particularly
hemoglobin,
hematocrit,
mean
corpuscular
volume,
which
higher
(
p
<
0.001).
In
contrast,
percentage
of
showed
white
cell
counts
below
2.5th
centile
healthy
controls
0.001),
except
days–1
year
age
A
similar
trend
observed
lymphocytes
0.001)
1-18
years
Discussion
These
newly
established
DS-specific
provide
crucial
evaluating
results,
potentially
reducing
unnecessary
tests
emphasizing
need
tailored
clinical
assessment
managing
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2023,
Номер
109(1), С. e25 - e31
Опубликована: Авг. 25, 2023
The
T4DM
study
randomized
1007
men
with
impaired
glucose
tolerance
or
newly
diagnosed
diabetes
to
testosterone
undecanoate
(TU,
1000
mg)
matching
placebo
(P)
injections
every
12
weeks
for
24
months
a
lifestyle
program
(T)
treatment
reducing
diagnosis
by
40%.The
long-term
effects
on
new
of
diabetes,
cardiovascular
and
prostate
disease,
sleep
apnea,
weight
maintenance
trajectory
androgen
dependence
were
not
yet
described.A
follow-up
email
survey
after
median
5.1
years
since
last
injection
obtained
599
(59%)
completed
surveys
(316
T,
283
P),
participants
in
the
compared
nonparticipants
23
anthropometric
demographic
variables.Randomization
was
TU
associated
stronger
belief
benefits
during
(64%
vs
49%,
P
<
.001)
but
(44%
40%,
=
.07);
there
is
high
interest
future
studies.
At
entry,
25%
had
apnea
more
frequent
(3.0%
0.4%,
.03)
during,
after,
study.
Poststudy,
resuming
prescribed
T
among
TU-treated
(6%
2.8%,
.03).
Five
cessation
no
difference
self-reported
rates
nor
change
loss
behaviors.We
conclude
that
without
pathological
hypogonadism
higher
levels
as
well
poststudy
consistent
some
receiving
prolonged
injectable
TU.
Blood Reviews,
Год журнала:
2023,
Номер
62, С. 101132 - 101132
Опубликована: Сен. 9, 2023
Despite
recent
advancements,
treatment
of
cytopenia
due
to
bone
marrow
failures
(BMF)
and
myeloid
neoplasms
remains
challenging.
Androgens
promote
renewal
maturation
blood
cells
may
be
beneficial
in
these
forms.
Here
we
report
a
systematic
review
androgens
use
as
single
agent
hematologic
conditions.
Forty-five
studies,
mainly
retrospective
with
various
androgen
types
doses,
were
included:
12
on
acquired
aplastic
anemia
(AA),
11
inherited
BMF,
17
myelodysplastic
syndromes
(MDS),
7
myelofibrosis.
Responses
ranged
from
50
70%
40–50%
AA
MDS,
while
very
limited
evidence
emerged
for
In
AA,
response
was
associated
presence
non-severe
disease;
MDS
more
effective
thrombocytopenia
or
mild
moderate
anemia,
whilst
benefit
observed
transfusion
dependent
anemia.
Toxicity
profile
consisted
virilization
liver
enzyme
elevation,
the
risk
leukemic
evolution
controversial.
BMC Endocrine Disorders,
Год журнала:
2023,
Номер
23(1)
Опубликована: Янв. 9, 2023
Both
age
and
gender
are
the
influence
factors
of
hemoglobin
concentration.
However,
changing
trend
levels
between
males
females
with
remains
unclear.
This
study
aimed
to
explore
their
characteristics
in
different
genders.A
cross-sectional
was
conducted
Physical
Examination
Center
First
Affiliated
Hospital
Wannan
Medical
College
Wuhu,
China
from
2014
2016.
The
generalized
linear
model
applied
relationship
age,
levels.Among
303,084
participants,
mean
for
46.9
±
13.4(15-98)
48.1
13.7(14-98)
years
old,
respectively.
Generalized
smoothing
splines
showed
that
increased
up
25
then
decreased
men;
women
until
20,
decreased,
slight
increase
again
(β
=
0.244,
P
<
0.01).
After
dividing
all
participants
into
hyperglycemia
normal
groups,
only
female
group
a
significant
upward
0.257,
0.01)
ages
50-59.Hemoglobin
concentration
changes
curve
is
females.
slightly
range
50-59
old
should
be
considered
developing
reference
making.
