Biomaterials, Год журнала: 2022, Номер 287, С. 121656 - 121656
Опубликована: Июнь 28, 2022
Язык: Английский
Acta Biomaterialia, Год журнала: 2022, Номер 149, С. 82 - 95
Опубликована: Июнь 29, 2022
Язык: Английский
Процитировано
55
Molecular Pharmaceutics, Год журнала: 2022, Номер 20(2), С. 886 - 904
Опубликована: Дек. 23, 2022
The integration of progressive technologies such as nanomedicine with the use natural products from traditional medicine (TM) provides a unique opportunity for longed-for harmonization between and modern medicine. Although several actions have been initiated decades ago, disparity reasons including some misunderstandings each other limits possibilities truly complementation. Herein, we analyze common challenges Chinese (TCM). These challenges, if solved in consensual way, can give boost to harmonization. Nanomedicine is recently born technology, while TCM has used by people thousands years. However, these disciplines, regulation standardization many protocols, especially related toxicity safety, regulatory aspects, manufacturing procedures, are under discussion. Besides, both still need achieve wider social acceptance. first briefly discuss strengths weaknesses TCM. This analysis serves focus afterward on aspects where mutually help bridge existing gaps Western As discussed, be applied TM general. Finally, recent successful cases scientific literature that merge reviewed examples benefits this
Язык: Английский
Процитировано
49
Frontiers in Oncology, Год журнала: 2022, Номер 12
Опубликована: Июль 14, 2022
The pathological processes of cancer are complex. Current methods used for chemotherapy have various limitations, such as cytotoxicity, multi-drug resistance, stem-like cells growth, and lack specificity. Several types nanomaterials treatment. Nanomaterials 1–100 nm in size special optical, magnetic, electrical characteristics. been fabricated treatments to overcome cytotoxicity low specificity, improve drug capacity bioavailability. Despite the increasing number related studies, few nanodrugs approved clinical use. To translation these materials, studies targeted delivery using nanocarriers needed. Cytotoxicity, enhanced permeability retention effects, protective role protein corona remain be addressed. This mini-review summarizes new manufactured use, analyses current barriers preventing their describes effective application
Язык: Английский
Процитировано
48
Bioactive Materials, Год журнала: 2022, Номер 17, С. 320 - 333
Опубликована: Фев. 1, 2022
Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, it is closely related to the free radical explosion overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed mediate efficient co-delivery siRNA against MOF (siMOF) microRNA-21 (miR21) into macrophages, cooperatively orchestrating microenvironment IR injury. Bioreducible, branched poly(β-amino ester) (BPAE-SS) designed co-condense siMOF miR21 NCs in multivalency-reinforced approach, they surface-decorated with carboxylated mannan (Man-COOH) shield positive surface charges enhance serum stability. The final MBSsm efficiently internalized by macrophages systemic administration, wherein BPAE-SS degraded small segments intracellular glutathione promote siMOF/miR21 release, finally provoking gene silencing. Thus, cardiomyocyte protection macrophage modulation realized via combined effects ROS scavenging, inflammation inhibition, autophagy attenuation, which ameliorates restores cardiac function cellular crosstalk. This study renders promising solutions address multiple barriers vivo nucleic acid delivery, also offers new options for manipulating reciprocal bio-reactions.
Язык: Английский
Процитировано
44
Biomaterials, Год журнала: 2022, Номер 287, С. 121656 - 121656
Опубликована: Июнь 28, 2022
Язык: Английский
Процитировано
44