Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Despite
the
development
of
many
injectable
hydrogels
intended
for
repair
myocardial
infarction
(MI),
their
effectiveness
is
often
compromised
because
they
target
merely
one
or
two
phases
MI's
pathological
progression.
Here,
a
multifunctional
hydrogel
delivery
platform
prepared
with
brand‐new
small
molecule
cross‐linker
stepwise
treatment
MI.
The
synthesis
and
reporting
novel
small‐molecule
phenylboronic
acid
((N(BA)
3
))
precise
molecular
structure
conducted
first
time,
it
successfully
utilized
polyvinyl
alcohol
(PVA)
dopamine
to
prepare
infarct
microenvironmental
responsiveness
anti‐oxidant.
Further,
considering
multistage
MI
repair,
contains
both
hyperoside
bioactive
nanoparticles
(EGCG@Hyp&Arg
NPs)
PLGA
microspheres
loaded
galunisertib
(PLGA@Gal
Ms).
EGCG@Hyp&Arg
NPs
are
rapidly
released
demonstrate
anti‐inflammatory
pro‐angiogenesis
effects,
while
in
long
term,
Gal
from
PLGA@Gal
Ms
inhibit
fibrosis
improve
cardiac
function.
Results
vitro
vivo
studies
reveal
that
engineered
programmed
capabilities
anti‐oxidation,
reducing
inflammation,
promoting
new
blood
vessel
formation,
inhibiting
fibrosis,
thereby
significantly
enhancing
heart
function
post‐MI.
Overall,
this
has
great
potential
application
as
therapeutic
strategy
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
13(12), С. 5107 - 5120
Опубликована: Июнь 20, 2023
Oxidative
stress
injury
and
mitochondrial
dysfunction
are
major
obstacles
to
neurological
functional
recovery
after
ischemic
stroke.
The
development
of
new
approaches
simultaneously
diminish
oxidative
resist
is
urgently
needed.
Inspired
by
the
overproduced
reactive
oxygen
species
(ROS)
at
neuron
mitochondria,
multifunctional
nanoparticles
with
ROS-responsiveness
mitochondrial-targeted
(SPNPs)
were
engineered,
achieving
specific
targeting
delivery
controllable
drug
release
penumbra.
Due
nose-to-brain
pathway,
SPNPs
which
encapsulated
in
a
thermo-sensitive
gel
intranasal
administration
directly
delivered
penumbra
bypassing
blood‒brain
barrier
(BBB)
enhancing
efficiency.
potential
for
stroke
treatment
was
systematically
evaluated
Advanced Materials,
Год журнала:
2024,
Номер
36(18)
Опубликована: Янв. 15, 2024
Abstract
Mitochondria,
widely
known
as
the
energy
factories
of
eukaryotic
cells,
have
a
myriad
vital
functions
across
diverse
cellular
processes.
Dysfunctions
within
mitochondria
serve
catalysts
for
various
diseases,
prompting
widespread
demise.
Mounting
research
on
remedying
damaged
indicates
that
constitute
valuable
target
therapeutic
intervention
against
diseases.
But
less
clinical
practice
and
lower
recovery
rate
imply
limitation
traditional
drugs,
which
need
further
breakthrough.
Nanotechnology
has
approached
favorable
regiospecific
biodistribution
high
efficacy
by
capitalizing
excellent
nanomaterials
targeting
drug
delivery.
Mitochondria‐remedying
nanodrugs
achieved
ideal
effects.
This
review
elucidates
significance
in
cells
organs,
while
also
compiling
mortality
data
related
Correspondingly,
nanodrug‐mediate
strategies
applicable
mitochondria‐remedying
disease
are
detailed,
with
full
understanding
roles
dysfunction
advantages
nanodrugs.
In
addition,
future
challenges
directions
discussed.
conclusion,
this
provides
comprehensive
insights
into
design
development
nanodrugs,
aiming
to
help
scientists
who
desire
extend
their
fields
engage
interdisciplinary
subject.
Circulation,
Год журнала:
2024,
Номер
149(25), С. 2002 - 2020
Опубликована: Июнь 17, 2024
Myocardial
infarction
is
a
cardiovascular
disease
characterized
by
high
incidence
rate
and
mortality.
It
leads
to
various
cardiac
pathophysiological
changes,
including
ischemia/reperfusion
injury,
inflammation,
fibrosis,
ventricular
remodeling,
which
ultimately
result
in
heart
failure
pose
significant
threat
global
health.
Although
clinical
reperfusion
therapies
conventional
pharmacological
interventions
improve
emergency
survival
rates
short-term
prognoses,
they
are
still
limited
providing
long-lasting
improvements
function
or
reversing
pathological
progression.
Recently,
patches
have
gained
considerable
attention
as
promising
therapy
for
myocardial
infarction.
These
consist
of
scaffolds
loaded
therapeutic
agents
that
provide
mechanical
reinforcement,
synchronous
electrical
conduction,
localized
delivery
within
the
infarct
zone
promote
restoration.
This
review
elucidates
progression
from
failure,
highlighting
targets
patches.
The
considers
primary
scaffold
materials,
synthetic,
natural,
conductive
prevalent
fabrication
techniques
optimal
properties
patch,
well
advanced
strategies.
Last,
current
limitations
prospects
patch
research
considered,
with
goal
shedding
light
on
innovative
products
poised
application.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(22), С. 26298 - 26315
Опубликована: Май 26, 2023
Intestinal
immune
dysfunction
and
gut
microbiota
dysbiosis
are
critically
causative
factors
in
the
pathogenesis
of
ulcerative
colitis
(UC);
however,
current
first-line
drugs
for
UC
treatment
clinics
often
remain
great
challenges
due
to
their
nontargeting
therapeutic
efficacy
severe
side
effects.
In
study,
colon-targeting
nanoparticles
based
on
Angelica
sinensis
polysaccharide
with
pH-
redox-responsiveness
were
fabricated
specifically
release
naturally
active
compound
ginsenoside
Rh2
colonic
inflammatory
site,
which
greatly
alleviated
symptoms
improved
microbial
homeostasis.
These
dual
responsive
Rh2-loaded
(Rh2/LA-UASP
NPs)
a
particle
size
117.00
±
4.80
nm
prepared
using
polymer
LA-UASP
obtained
by
grafting
A.
urocanic
acid
α-lipoic
(α-LA).
As
expected,
these
Rh2/LA-UASP
NPs
achieved
redox-responsive
drug
at
pH
5.5
10
mM
GSH.
The
stability,
biocompatibility,
vivo
safety
experiments
exhibited
had
excellent
ability
significant
accumulation
colon.
Meanwhile,
could
escape
from
lysosomes
be
efficiently
internalized
into
intestinal
mucosal
cells,
thereby
effectively
inhibiting
proinflammatory
cytokines.
animal
indicated
that
significantly
integrity
mucosa
increased
colon
length
compared
mice.
Additionally,
weight
loss,
histological
damage,
inflammation
level
ameliorated.
homeostasis
flora
short-chain
fatty
acids
(SCFAs)
after
being
treated
Our
study
proved
pH-and
promising
candidates
treatment.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(30)
Опубликована: Апрель 26, 2023
Abstract
Vascular
restenosis
after
balloon
dilation
is
largely
caused
by
the
over‐proliferation
of
smooth
muscle
cells,
which
triggered
and
exacerbated
local
excessive
inflammation
oxidative
stress.
The
inflammatory
stress
cause
tissue/cell
damage,
hamper
endothelial
functions,
worsen
intimal
hyperplasia
restenosis.
A
high
level
reactive
oxygen
species
(ROS)
overproduction
regarded
as
main
culprit.
Therefore,
efficiently
inhibiting
ROS
over‐production
or
weightily
depleting
them
great
significance.
Herein,
a
“ROS‐responsive/scavenging
prodrug”
introduced
into
coating
for
treatment
vascular
reversible
phenylboronic
ester‐bearing
caffeic
acid
(CA)
macromolecular
prodrug
(PBC)
designed
controlled
on‐demand
dual‐drug
release
level;
released
CA
4‐hydroxybenzyl
alcohol
exhibit
efficient
antioxidant
anti‐inflammatory
effects
scavenging
ROS,
thereby
regulating
microenvironment
protecting
endothelium
functions.
To
accelerate
regeneration,
pro‐endothelial
microRNA‐126
further
introduced.
ROS‐responsive/scavenging
prodrug/miRNA
prevents
hyperplasia,
alleviates
inflammation,
improves
healing
in
rat
abdominal
aorta
model,
may
provide
applicative
perspectives
next‐generation
drug‐coated
balloons
other
cardiovascular
diseases
treatment.
Intervertebral
disc
degeneration
(IVDD)
is
a
significant
contributor
to
low
back
pain,
characterized
by
excessive
reactive
oxygen
species
generation
and
inflammation-induced
pyroptosis.
Unfortunately,
there
are
currently
no
specific
molecules
or
materials
available
effectively
delay
IVDD.
This
study
develops
multifunctional
full
name
of
PG@Cu
nanoparticle
network
(PG@Cu).
A
designed
pentapeptide,
bonded
on
nanoparticles
via
Schiff
base
bond,
imparts
multifunctionality
the
metal
polyphenol
particles
(PG@Cu-FP).
PG@Cu-FP
exhibits
enhanced
escape
from
lysosomal
capture,
enabling
efficient
targeting
mitochondria
scavenge
excess
species.
The
scavenging
activity
against
originates
polyphenol-based
structures
within
nanoparticles.
Furthermore,
Pyroptosis
blocked
inhibiting
Gasdermin
mediated
pore
formation
membrane
rupture.
successfully
reduces
activation
nucleotide-binding
oligomerization
domain-like
receptor
family
pyrin
domain-containing
3
inflammasome
protein
(Gasdermin
D,
GSDMD)
oligomerization,
leading
reduced
expression
Nod-like
receptors.
multifaceted
approach
demonstrates
higher
efficiency
in
Pyroptosis.
Experimental
results
confirm
that
preserves
height,
retains
water
content,
tissue
structure.
These
findings
highlight
potential
improving
IVDD
provide
novel
insights
for
future
research
treatments.
