Materials,
Год журнала:
2022,
Номер
15(13), С. 4446 - 4446
Опубликована: Июнь 24, 2022
The
existing
harder
biomaterial
does
not
protect
the
tissue
cells
with
blunt-force
trauma
effects,
making
it
a
poor
choice
for
articular
cartilage
scaffold
design.
Despite
traditional
mechanical
strengths,
this
study
aims
to
discover
alternative
structural
strengths
supports.
metallic
filler
polymer
reinforced
method
was
used
fabricate
test
specimen,
either
low
brass
(Cu80Zn20)
or
titanium
dioxide
filler,
composition
weight
percentages
(wt.%)
of
0,
2,
5,
15,
and
30
in
polyester
urethane
adhesive.
specimens
were
investigated
tensile,
flexural,
field
emission
scanning
electron
microscopy
(FESEM),
X-ray
diffraction
(XRD)
tests.
tensile
flexural
results
increased
wt.%,
but
there
higher
values
specimens.
strength
curves
extended
an
additional
occurring
before
83%
wt.%.
stress
because
Cu
solvent
Zn
solute
substituting
each
other
randomly.
FESEM
micrograph
showed
cubo-octahedron
shaped
structure
that
similar
AuCu3
class.
XRD
pattern
two
prominent
peaks
2θ
42.6°
(110)
49.7°
(200)
d-spacings
1.138
Å
1.010
Å,
respectively,
indicated
typical
face-centred
cubic
superlattice
atoms.
Compared
copper,
zinc,
cart
brass,
these
structures
had
ordered-disordered
transitional
states.
As
result,
created
by
This
innovative
has
potential
develop
into
anti-trauma
osteoarthritic
patients.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 13, 2025
The
latest
research
on
nanotechnology
through
the
new
tailored
scaffolds
encompassed
therapeutic
effects
of
natural
compounds,
and
unique
properties
metallic
nanoparticles
offer
possibilities
in
emerging
biomedical
fields.
Various
strategies
have
been
developed
to
address
limitations
existing
agents
concerning
specificity,
vectorization,
bioavailability,
drug
resistance,
adverse
effects.
In
this
study,
medicinal
plant
Portulaca
oleracea
L.
magnetite
were
used
develop
an
innovative
target
carrier
system,
designed
enhance
cytotoxic
effect
overcome
main
drawbacks
(permeability
localization)
phytoconstituents.
low-metabolite
profile
Romanian
wild-grown
exhibits
a
diverse
range
hundred
fifty-five
compounds
across
various
chemical
categories
(amino
acids,
peptides,
fatty
flavonoids,
alkaloids,
terpenoids,
phenolic
organic
esters,
sterols,
coumarins,
nucleosides,
lignans,
miscellaneous
compounds).
Morpho-structural
magnetic
phytocarrier
investigated
using
variety
methods,
including
XRD,
FTIR,
Raman,
SEM,
DLS),
determinations.
MTT
assay
was
conducted
evaluate
vitro
potential
cytotoxicity
normal
human
dermal
fibroblasts
(NHDF),
as
well
two
tumoral
cell
lines:
osteosarcoma
(HOS)
cervical
cancer
(HeLa).
Results
indicated
that
significant
inhibition
both
lines'
viability
exerted
by
compared
herbal
extract.
Furthermore,
results
obtained
for
total
content
antioxidant
screening
performed
FRAP
DPPH
assays
superior
system.
These
findings
suggest
applications
system
its
promising
implications
future
development
field.
Abstract
Dialdehyde
cellulose
(DAC)
prepared
from
sugarcane
bagasse
(SC)
by
an
eco-friendly,
fast
and
low-cost
microwave
method
was
used
for
loading
sustained
release
of
4-aminoacetophenone
(4-AAP).
DAC
reacted
with
chitosan
(Ch)
4-AAP
via
a
Schiff
base
reaction.
FTIR
analysis
confirmed
successful
formation
between
Ch,
evidenced
the
disappearance
aldehyde
peak
at
1716
cm⁻
1
appearance
imine
1631
,
as
well
strong
hydrogen
bonding
incorporated
4-AAP,
indicated
shift
in
O–H
stretch
3336
to
3330
.Swelling
studies
showed
increased
water
absorption
higher
content,
4-AAP@DAC/Ch2
demonstrating
pseudo-second-order
kinetics
non-Fickian
diffusion.
The
DFT
calculations
revealed
that
4-AAP@DAC/Ch
hydrogel
exhibited
enhanced
stability
reactivity.
A
significantly
reduced
HOMO–LUMO
energy
gap,
coupled
negative
Pi
values,
interactions
DAC,
chitosan,
4-AAP.
high
adsorption
further
supported
observed
slow
drug
release,
validating
experimental
findings.
Graphical
Cells,
Год журнала:
2023,
Номер
12(7), С. 1018 - 1018
Опубликована: Март 26, 2023
Exosomes
are
effective
therapeutic
vehicles
that
may
transport
their
substances
across
cells.
They
shown
to
possess
the
capacity
affect
cell
proliferation,
migration,
anti-apoptosis,
anti-scarring,
and
angiogenesis,
via
action
of
transporting
molecular
components.
Possessing
immense
potential
in
regenerative
medicine,
exosomes,
especially
stem
cell-derived
have
advantages
low
immunogenicity,
minimal
invasiveness,
broad
clinical
applicability.
Exosome
biodistribution
pharmacokinetics
be
altered,
response
recent
advancements
technology,
for
purpose
treating
particular
illnesses.
Yet,
prior
application,
it
is
crucial
ascertain
ideal
dose
any
negative
consequences
an
exosome.
This
review
focuses
on
exosomes
further
illustrates
mechanisms
underpin
musculoskeletal
regeneration,
wound
healing,
female
infertility,
cardiac
recovery,
immunomodulation,
neurological
disease,
metabolic
regulation.
In
addition,
we
provide
a
summary
currently
techniques
isolating
describe
innovations
biomaterials
improve
efficacy
exosome-based
treatments.
Overall,
this
paper
provides
updated
overview
biological
factors
found
as
well
targets
future
cell-free
applications.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(24)
Опубликована: Ноя. 22, 2022
Human
articular
cartilage
has
a
poor
ability
to
self-repair,
meaning
small
injuries
often
lead
osteoarthritis,
painful
and
debilitating
condition
which
is
major
contributor
the
global
burden
of
disease.
Existing
clinical
strategies
generally
do
not
regenerate
hyaline
type
cartilage,
motivating
research
toward
tissue
engineering
solutions.
Prospective
therapies
can
be
placed
into
two
broad
categories:
i)
Ex
situ
strategies,
where
constructs
are
engineered
in
lab
prior
implantation
ii)
cells
and/or
bioscaffold
delivered
defect
site
stimulate
chondral
repair
directly.
While
commonalities
exist
between
these
approaches,
core
point
distinction-whether
chondrogenesis
primarily
occurs
"within"
or
"without"
(outside)
body-can
dictate
many
aspects
treatment.
This
difference
influences
decisions
around
cell
selection,
biomaterials
formulation
surgical
procedure,
processes
integration
maturation,
as
well
as,
prospects
for
regulatory
clearance
translation.
Here,
ex
compared:
Highlighting
their
respective
challenges,
opportunities,
on
translational
pathways
long
term
human
repair.
Biomedical Technology,
Год журнала:
2022,
Номер
1, С. 30 - 38
Опубликована: Ноя. 17, 2022
Oral
delivery
is
with
high
patient
compliance
but
low
bioavailability
and
controllability.
The
emerging
microfluidics-derived
microcarriers
have
sprung
up
to
relieve
the
hurdles.
Herein,
a
review
on
recent
progress
in
applying
for
oral
presented.
First,
we
briefly
introduce
microfluidic
fabrication
of
based
laminar
flow
droplets.
Then,
focus
applications
stomach,
small
intestine,
colon.
Last
not
least,
discuss
challenges
outlooks
microparticles
end.
This
anticipated
help
readers
follow
research
frontiers
this
field,
guide
future
development
direction
microcarriers.
Abstract
The
use
of
natural
cartilage
extracellular
matrix
(ECM)
has
gained
widespread
attention
in
the
field
tissue
engineering.
However,
current
approaches
for
delivering
functional
scaffolds
osteoarthritis
(OA)
therapy
rely
on
knee
surgery,
which
is
limited
by
narrow
and
complex
structure
articular
cavity
carries
risk
injuring
surrounding
tissues.
This
work
introduces
a
novel
cell
microcarrier,
magnetized
ECM‐derived
(M‐CEDSs),
are
derived
from
decellularized
porcine
ECM.
Human
bone
marrow
mesenchymal
stem
cells
selected
their
therapeutic
potential
OA
treatments.
Owing
to
composition,
M‐CEDSs
have
biomechanical
environment
similar
that
human
can
efficiently
load
while
maintaining
high
mobility.
released
spontaneously
at
target
location
least
20
days.
Furthermore,
cell‐seeded
show
better
joint
function
recovery
than
control
groups
3
weeks
after
surgery
preclinical
experiments,
ex
vivo
experiments
reveal
rapidly
aggregate
inside
samples.
demonstrates
microrobots
delivery
effects
tests.
Nano-Micro Letters,
Год журнала:
2023,
Номер
16(1)
Опубликована: Ноя. 30, 2023
Synthetic
micromotor
has
gained
substantial
attention
in
biomedicine
and
environmental
remediation.
Metal-based
degradable
composed
of
magnesium
(Mg),
zinc
(Zn),
iron
(Fe)
have
promise
due
to
their
nontoxic
fuel-free
propulsion,
favorable
biocompatibility,
safe
excretion
degradation
products
Recent
advances
metallic
shown
fast
movement
complex
biological
media,
efficient
cargo
delivery
biocompatibility.
A
noteworthy
number
metal-based
micromotors
employ
bubble
utilizing
water
as
fuel
generate
hydrogen
bubbles.
This
novel
feature
projected
for
active
vivo
drug
applications.
In
addition,
understanding
the
mechanism
these
is
also
a
key
parameter
design
performance.
Its
propulsion
efficiency
life
span
govern
overall
performance
micromotor.
Here
we
review
recent
advancements
micromotors.
Furthermore,
describe
controlled
degradation,
delivery,
built-in
acid
neutralization
capabilities
with
versatile
biomedical
Moreover,
discuss
micromotors'
efficacy
detecting
destroying
pollutants.
Finally,
address
limitations
future
research
directions
