Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(7)
Опубликована: Март 20, 2024
Abstract
Articular
cartilage
defect
is
challenged
by
insufficient
regenerative
ability
of
cartilage.
Catalpol
(CA),
the
primary
active
component
Rehmanniae
Radix,
could
exert
protective
effects
against
various
diseases.
However,
impact
CA
on
treatment
articular
injuries
still
unclear.
In
this
study,
full‐thickness
was
induced
in
a
mouse
model
via
surgery.
The
animals
were
intraperitoneally
injected
with
for
4
or
8
weeks.
According
to
results
macroscopic
observation,
micro‐computed
tomography
CT
(μCT),
histological
and
immunohistochemistry
staining,
promote
repair,
resulting
regeneration,
bone
structure
improvement
matrix
anabolism.
Specifically,
an
increase
expression
CD90,
marker
mesenchymal
stem
cells
(MSCs),
observed.
addition,
we
evaluated
migratory
chondrogenic
MSCs.
Different
concentration
added
C3H10
T1/2
cells.
showed
that
enhanced
cell
migration
chondrogenesis
without
affecting
proliferation.
Collectively,
our
findings
indicate
may
be
effective
defects
stimulation
endogenous
Materials Today Bio,
Год журнала:
2023,
Номер
23, С. 100870 - 100870
Опубликована: Ноя. 17, 2023
Human
cartilage
tissue
can
be
categorized
into
three
types:
hyaline
cartilage,
elastic
and
fibrocartilage.
Each
type
of
possesses
unique
properties
functions,
which
presents
a
significant
challenge
for
the
regeneration
repair
damaged
tissue.
Bionics
is
discipline
in
humans
study
imitate
nature.
A
bionic
strategy
based
on
comprehensive
knowledge
anatomy
histology
human
expected
to
contribute
fundamental
core
elements
repair.
Moreover,
as
novel
tissue-engineered
technology,
3D
bioprinting
has
distinctive
advantage
rapid
precise
construction
targeted
models.
Thus,
by
selecting
suitable
materials,
cells
cytokines,
leveraging
advanced
printing
technology
concepts,
it
becomes
possible
simultaneously
realize
multiple
beneficial
achieve
improved
This
article
provides
an
overview
key
involved
combination
strategies,
with
particular
focus
recent
advances
mimicking
different
types
Cells,
Год журнала:
2023,
Номер
12(7), С. 1018 - 1018
Опубликована: Март 26, 2023
Exosomes
are
effective
therapeutic
vehicles
that
may
transport
their
substances
across
cells.
They
shown
to
possess
the
capacity
affect
cell
proliferation,
migration,
anti-apoptosis,
anti-scarring,
and
angiogenesis,
via
action
of
transporting
molecular
components.
Possessing
immense
potential
in
regenerative
medicine,
exosomes,
especially
stem
cell-derived
have
advantages
low
immunogenicity,
minimal
invasiveness,
broad
clinical
applicability.
Exosome
biodistribution
pharmacokinetics
be
altered,
response
recent
advancements
technology,
for
purpose
treating
particular
illnesses.
Yet,
prior
application,
it
is
crucial
ascertain
ideal
dose
any
negative
consequences
an
exosome.
This
review
focuses
on
exosomes
further
illustrates
mechanisms
underpin
musculoskeletal
regeneration,
wound
healing,
female
infertility,
cardiac
recovery,
immunomodulation,
neurological
disease,
metabolic
regulation.
In
addition,
we
provide
a
summary
currently
techniques
isolating
describe
innovations
biomaterials
improve
efficacy
exosome-based
treatments.
Overall,
this
paper
provides
updated
overview
biological
factors
found
as
well
targets
future
cell-free
applications.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(24)
Опубликована: Ноя. 22, 2022
Human
articular
cartilage
has
a
poor
ability
to
self-repair,
meaning
small
injuries
often
lead
osteoarthritis,
painful
and
debilitating
condition
which
is
major
contributor
the
global
burden
of
disease.
Existing
clinical
strategies
generally
do
not
regenerate
hyaline
type
cartilage,
motivating
research
toward
tissue
engineering
solutions.
Prospective
therapies
can
be
placed
into
two
broad
categories:
i)
Ex
situ
strategies,
where
constructs
are
engineered
in
lab
prior
implantation
ii)
cells
and/or
bioscaffold
delivered
defect
site
stimulate
chondral
repair
directly.
While
commonalities
exist
between
these
approaches,
core
point
distinction-whether
chondrogenesis
primarily
occurs
"within"
or
"without"
(outside)
body-can
dictate
many
aspects
treatment.
This
difference
influences
decisions
around
cell
selection,
biomaterials
formulation
surgical
procedure,
processes
integration
maturation,
as
well
as,
prospects
for
regulatory
clearance
translation.
Here,
ex
compared:
Highlighting
their
respective
challenges,
opportunities,
on
translational
pathways
long
term
human
repair.
Biomedical Technology,
Год журнала:
2022,
Номер
1, С. 30 - 38
Опубликована: Ноя. 17, 2022
Oral
delivery
is
with
high
patient
compliance
but
low
bioavailability
and
controllability.
The
emerging
microfluidics-derived
microcarriers
have
sprung
up
to
relieve
the
hurdles.
Herein,
a
review
on
recent
progress
in
applying
for
oral
presented.
First,
we
briefly
introduce
microfluidic
fabrication
of
based
laminar
flow
droplets.
Then,
focus
applications
stomach,
small
intestine,
colon.
Last
not
least,
discuss
challenges
outlooks
microparticles
end.
This
anticipated
help
readers
follow
research
frontiers
this
field,
guide
future
development
direction
microcarriers.
Abstract
The
use
of
natural
cartilage
extracellular
matrix
(ECM)
has
gained
widespread
attention
in
the
field
tissue
engineering.
However,
current
approaches
for
delivering
functional
scaffolds
osteoarthritis
(OA)
therapy
rely
on
knee
surgery,
which
is
limited
by
narrow
and
complex
structure
articular
cavity
carries
risk
injuring
surrounding
tissues.
This
work
introduces
a
novel
cell
microcarrier,
magnetized
ECM‐derived
(M‐CEDSs),
are
derived
from
decellularized
porcine
ECM.
Human
bone
marrow
mesenchymal
stem
cells
selected
their
therapeutic
potential
OA
treatments.
Owing
to
composition,
M‐CEDSs
have
biomechanical
environment
similar
that
human
can
efficiently
load
while
maintaining
high
mobility.
released
spontaneously
at
target
location
least
20
days.
Furthermore,
cell‐seeded
show
better
joint
function
recovery
than
control
groups
3
weeks
after
surgery
preclinical
experiments,
ex
vivo
experiments
reveal
rapidly
aggregate
inside
samples.
demonstrates
microrobots
delivery
effects
tests.
Nano-Micro Letters,
Год журнала:
2023,
Номер
16(1)
Опубликована: Ноя. 30, 2023
Synthetic
micromotor
has
gained
substantial
attention
in
biomedicine
and
environmental
remediation.
Metal-based
degradable
composed
of
magnesium
(Mg),
zinc
(Zn),
iron
(Fe)
have
promise
due
to
their
nontoxic
fuel-free
propulsion,
favorable
biocompatibility,
safe
excretion
degradation
products
Recent
advances
metallic
shown
fast
movement
complex
biological
media,
efficient
cargo
delivery
biocompatibility.
A
noteworthy
number
metal-based
micromotors
employ
bubble
utilizing
water
as
fuel
generate
hydrogen
bubbles.
This
novel
feature
projected
for
active
vivo
drug
applications.
In
addition,
understanding
the
mechanism
these
is
also
a
key
parameter
design
performance.
Its
propulsion
efficiency
life
span
govern
overall
performance
micromotor.
Here
we
review
recent
advancements
micromotors.
Furthermore,
describe
controlled
degradation,
delivery,
built-in
acid
neutralization
capabilities
with
versatile
biomedical
Moreover,
discuss
micromotors'
efficacy
detecting
destroying
pollutants.
Finally,
address
limitations
future
research
directions
Journal of Orthopaedic Translation,
Год журнала:
2024,
Номер
48, С. 70 - 88
Опубликована: Июль 31, 2024
Tendon-bone
interface
(TBI)
repair
is
slow
and
challenging
owing
to
its
hierarchical
structure,
gradient
composition,
complex
function.
In
this
work,
enlightened
by
the
natural
characteristics
of
TBI
microstructure
demands
regeneration,
a
function-based
scaffold
was
fabricated.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
64(15), С. 4966 - 4976
Опубликована: Ноя. 17, 2022
Edible
microcarriers
are
essential
for
developing
cell-based
meat
in
large-scale
cell
cultures.
As
they
required
to
be
embedded
the
final
products,
should
edible,
biocompatible,
cost-effective,
and
pathogen-free.
The
invention
of
edible
animal-free
would
a
breakthrough
culture.
We
reviewed
fabrication
techniques
materials
microcarriers,
found
that
plant
proteins,
having
diverse
structures
composition,
could
possess
active
domains
hypnotized
replace
animal-based
extracellular
matrix
(ECM)
culture
applications.
In
addition,
bioactive
peptides
plants
have
been
most
them
were
resulted
from
enzyme
hydrolysis.
Therefore,
proteins
with
rich
potential
development
microcarriers.
Our
work
provided
some
new
trains
thought
plant-based
biomaterials
as
ECM
advances
