Structural Strength Analyses for Low Brass Filler Biomaterial with Anti-Trauma Effects in Articular Cartilage Scaffold Design DOI Open Access
Yan Yik Lim, Azizi Miskon,

Ahmad Mujahid Ahmad Zaidi

и другие.

Materials, Год журнала: 2022, Номер 15(13), С. 4446 - 4446

Опубликована: Июнь 24, 2022

The existing harder biomaterial does not protect the tissue cells with blunt-force trauma effects, making it a poor choice for articular cartilage scaffold design. Despite traditional mechanical strengths, this study aims to discover alternative structural strengths supports. metallic filler polymer reinforced method was used fabricate test specimen, either low brass (Cu80Zn20) or titanium dioxide filler, composition weight percentages (wt.%) of 0, 2, 5, 15, and 30 in polyester urethane adhesive. specimens were investigated tensile, flexural, field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) tests. tensile flexural results increased wt.%, but there higher values specimens. strength curves extended an additional occurring before 83% wt.%. stress because Cu solvent Zn solute substituting each other randomly. FESEM micrograph showed cubo-octahedron shaped structure that similar AuCu3 class. XRD pattern two prominent peaks 2θ 42.6° (110) 49.7° (200) d-spacings 1.138 Å 1.010 Å, respectively, indicated typical face-centred cubic superlattice atoms. Compared copper, zinc, cart brass, these structures had ordered-disordered transitional states. As result, created by This innovative has potential develop into anti-trauma osteoarthritic patients.

Язык: Английский

Injectable chitosan microspheres resisting inflammatory and oxidative stress for ameliorating intervertebral disc degeneration DOI
Lin Huang,

Wantao Wang,

Lei Liu

и другие.

Science China Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

1

Wild grown Portulaca oleracea as a novel magnetite based carrier with in vitro antioxidant and cytotoxicity potential DOI Creative Commons
Adina‐Elena Segneanu, Gabriela Vlase, C.N. Marin

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 13, 2025

The latest research on nanotechnology through the new tailored scaffolds encompassed therapeutic effects of natural compounds, and unique properties metallic nanoparticles offer possibilities in emerging biomedical fields. Various strategies have been developed to address limitations existing agents concerning specificity, vectorization, bioavailability, drug resistance, adverse effects. In this study, medicinal plant Portulaca oleracea L. magnetite were used develop an innovative target carrier system, designed enhance cytotoxic effect overcome main drawbacks (permeability localization) phytoconstituents. low-metabolite profile Romanian wild-grown exhibits a diverse range hundred fifty-five compounds across various chemical categories (amino acids, peptides, fatty flavonoids, alkaloids, terpenoids, phenolic organic esters, sterols, coumarins, nucleosides, lignans, miscellaneous compounds). Morpho-structural magnetic phytocarrier investigated using variety methods, including XRD, FTIR, Raman, SEM, DLS), determinations. MTT assay was conducted evaluate vitro potential cytotoxicity normal human dermal fibroblasts (NHDF), as well two tumoral cell lines: osteosarcoma (HOS) cervical cancer (HeLa). Results indicated that significant inhibition both lines' viability exerted by compared herbal extract. Furthermore, results obtained for total content antioxidant screening performed FRAP DPPH assays superior system. These findings suggest applications system its promising implications future development field.

Язык: Английский

Процитировано

1

Microwaved schiff base dialdehyde cellulose-chitosan hydrogels for sustained drug release with DFT calculations DOI Creative Commons

Hebat‐Allah S. Tohamy

BMC Chemistry, Год журнала: 2025, Номер 19(1)

Опубликована: Май 2, 2025

Abstract Dialdehyde cellulose (DAC) prepared from sugarcane bagasse (SC) by an eco-friendly, fast and low-cost microwave method was used for loading sustained release of 4-aminoacetophenone (4-AAP). DAC reacted with chitosan (Ch) 4-AAP via a Schiff base reaction. FTIR analysis confirmed successful formation between Ch, evidenced the disappearance aldehyde peak at 1716 cm⁻ 1 appearance imine 1631 , as well strong hydrogen bonding incorporated 4-AAP, indicated shift in O–H stretch 3336 to 3330 .Swelling studies showed increased water absorption higher content, 4-AAP@DAC/Ch2 demonstrating pseudo-second-order kinetics non-Fickian diffusion. The DFT calculations revealed that 4-AAP@DAC/Ch hydrogel exhibited enhanced stability reactivity. A significantly reduced HOMO–LUMO energy gap, coupled negative Pi values, interactions DAC, chitosan, 4-AAP. high adsorption further supported observed slow drug release, validating experimental findings. Graphical

Язык: Английский

Процитировано

1

Oxygen metabolism-balanced engineered hydrogel microspheres promote the regeneration of the nucleus pulposus by inhibiting acid-sensitive complexes DOI Creative Commons
Ziang Li, Feng Cai, Jincheng Tang

и другие.

Bioactive Materials, Год журнала: 2022, Номер 24, С. 346 - 360

Опубликована: Дек. 30, 2022

Intervertebral disc degeneration (IVDD) is commonly caused by imbalanced oxygen metabolism-triggered inflammation. Overcoming the shortcomings of antioxidants in IVDD treatment, including instability and lack targeting, remains challenging. Microfluidic surface modification technologies were combined to graft chitosan nanoparticles encapsulated with strong reductive black phosphorus quantum dots (BPQDs) onto GelMA microspheres via amide bonds construct metabolism-balanced engineered hydrogel (GM@CS-BP), which attenuate extracellular acidosis nucleus pulposus (NP), block inflammatory cascade, reduce matrix metalloproteinase expression (MMP), remodel (ECM) intervertebral discs (IVDs). The GM@CS-BP H2O2 intensity 229%. Chemical grafting electrostatic attraction increase encapsulation rate BPQDs 167% maintain stable release for 21 days, demonstrating antioxidant properties sustained modulation BPQDs. After western blotting revealed decreased acid-sensitive ion channel-3 factors. Histological staining an 8-week model confirmed regeneration NP. therefore a balance between ECM synthesis degradation regulating positive feedback metabolism IVDs This study provides in-depth interpretation mechanisms underlying antioxidation new approach treatment.

Язык: Английский

Процитировано

29

Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes DOI Creative Commons
Liang-Yun Chen, Ting‐Wan Kao, Chang-Cyuan Chen

и другие.

Cells, Год журнала: 2023, Номер 12(7), С. 1018 - 1018

Опубликована: Март 26, 2023

Exosomes are effective therapeutic vehicles that may transport their substances across cells. They shown to possess the capacity affect cell proliferation, migration, anti-apoptosis, anti-scarring, and angiogenesis, via action of transporting molecular components. Possessing immense potential in regenerative medicine, exosomes, especially stem cell-derived have advantages low immunogenicity, minimal invasiveness, broad clinical applicability. Exosome biodistribution pharmacokinetics be altered, response recent advancements technology, for purpose treating particular illnesses. Yet, prior application, it is crucial ascertain ideal dose any negative consequences an exosome. This review focuses on exosomes further illustrates mechanisms underpin musculoskeletal regeneration, wound healing, female infertility, cardiac recovery, immunomodulation, neurological disease, metabolic regulation. In addition, we provide a summary currently techniques isolating describe innovations biomaterials improve efficacy exosome-based treatments. Overall, this paper provides updated overview biological factors found as well targets future cell-free applications.

Язык: Английский

Процитировано

15

Within or Without You? A Perspective Comparing In Situ and Ex Situ Tissue Engineering Strategies for Articular Cartilage Repair DOI Creative Commons
Cathal O’Connell, Serena Duchi, Carmine Onofrillo

и другие.

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(24)

Опубликована: Ноя. 22, 2022

Human articular cartilage has a poor ability to self-repair, meaning small injuries often lead osteoarthritis, painful and debilitating condition which is major contributor the global burden of disease. Existing clinical strategies generally do not regenerate hyaline type cartilage, motivating research toward tissue engineering solutions. Prospective therapies can be placed into two broad categories: i) Ex situ strategies, where constructs are engineered in lab prior implantation ii) cells and/or bioscaffold delivered defect site stimulate chondral repair directly. While commonalities exist between these approaches, core point distinction-whether chondrogenesis primarily occurs "within" or "without" (outside) body-can dictate many aspects treatment. This difference influences decisions around cell selection, biomaterials formulation surgical procedure, processes integration maturation, as well as, prospects for regulatory clearance translation. Here, ex compared: Highlighting their respective challenges, opportunities, on translational pathways long term human repair.

Язык: Английский

Процитировано

22

Microfluidics-derived microcarrier systems for oral delivery DOI Creative Commons
Lijun Cai, Ning Li, Yong Zhang

и другие.

Biomedical Technology, Год журнала: 2022, Номер 1, С. 30 - 38

Опубликована: Ноя. 17, 2022

Oral delivery is with high patient compliance but low bioavailability and controllability. The emerging microfluidics-derived microcarriers have sprung up to relieve the hurdles. Herein, a review on recent progress in applying for oral presented. First, we briefly introduce microfluidic fabrication of based laminar flow droplets. Then, focus applications stomach, small intestine, colon. Last not least, discuss challenges outlooks microparticles end. This anticipated help readers follow research frontiers this field, guide future development direction microcarriers.

Язык: Английский

Процитировано

20

Using Decellularized Magnetic Microrobots to Deliver Functional Cells for Cartilage Regeneration DOI
Hanjin Huang, Junyang Li, Cheng Wang

и другие.

Small, Год журнала: 2023, Номер 20(11)

Опубликована: Ноя. 8, 2023

Abstract The use of natural cartilage extracellular matrix (ECM) has gained widespread attention in the field tissue engineering. However, current approaches for delivering functional scaffolds osteoarthritis (OA) therapy rely on knee surgery, which is limited by narrow and complex structure articular cavity carries risk injuring surrounding tissues. This work introduces a novel cell microcarrier, magnetized ECM‐derived (M‐CEDSs), are derived from decellularized porcine ECM. Human bone marrow mesenchymal stem cells selected their therapeutic potential OA treatments. Owing to composition, M‐CEDSs have biomechanical environment similar that human can efficiently load while maintaining high mobility. released spontaneously at target location least 20 days. Furthermore, cell‐seeded show better joint function recovery than control groups 3 weeks after surgery preclinical experiments, ex vivo experiments reveal rapidly aggregate inside samples. demonstrates microrobots delivery effects tests.

Язык: Английский

Процитировано

13

Recent Developments in Metallic Degradable Micromotors for Biomedical and Environmental Remediation Applications DOI Creative Commons
Sourav Dutta,

Seungmin Noh,

Roger Sanchis‐Gual

и другие.

Nano-Micro Letters, Год журнала: 2023, Номер 16(1)

Опубликована: Ноя. 30, 2023

Synthetic micromotor has gained substantial attention in biomedicine and environmental remediation. Metal-based degradable composed of magnesium (Mg), zinc (Zn), iron (Fe) have promise due to their nontoxic fuel-free propulsion, favorable biocompatibility, safe excretion degradation products Recent advances metallic shown fast movement complex biological media, efficient cargo delivery biocompatibility. A noteworthy number metal-based micromotors employ bubble utilizing water as fuel generate hydrogen bubbles. This novel feature projected for active vivo drug applications. In addition, understanding the mechanism these is also a key parameter design performance. Its propulsion efficiency life span govern overall performance micromotor. Here we review recent advancements micromotors. Furthermore, describe controlled degradation, delivery, built-in acid neutralization capabilities with versatile biomedical Moreover, discuss micromotors' efficacy detecting destroying pollutants. Finally, address limitations future research directions

Язык: Английский

Процитировано

13

Advancing bone regeneration: Unveiling the potential of 3D cell models in the evaluation of bone regenerative materials DOI
Minglu Hao,

Linyuan Xue,

Xiaobo Wen

и другие.

Acta Biomaterialia, Год журнала: 2024, Номер 183, С. 1 - 29

Опубликована: Май 28, 2024

Язык: Английский

Процитировано

5