Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways DOI Creative Commons

Parya Pashootan,

Fatemeh Saadati,

Hossein Fahimi

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 649, С. 123622 - 123622

Опубликована: Ноя. 19, 2023

Photodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on administration photosensitizer (PS) subsequent irradiation with light specific wavelengths, thereby generating reactive oxygen species (ROS) within targeted cells. The cellular effects PDT are dependent both localization PS severity ROS challenge, potentially leading to stimulation various cell death modalities. For many years, concept regulated (RCD) triggered by photodynamic reactions predominantly encompassed apoptosis, necrosis, autophagy. However, recent decades, further explorations have unveiled additional modalities, such as necroptosis, ferroptosis, cuproptosis, pyroptosis, parthanatos, immunogenic (ICD), which helps achieve tumor elimination. Recently, nanoparticles (NPs) demonstrated substantial advantages over traditional PSs become important components PDT, due their improved physicochemical properties, enhanced solubility superior specificity for review aims summarize advancements applications different metal-based NPs or delivery systems optimized cancer treatment. Furthermore, it mechanistically highlights contribution RCD pathways during metal how these forms can improve regimens therapy.

Язык: Английский

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects DOI

Shuang Zeng,

Xiaosheng Liu, Yves S. Kafuti

и другие.

Chemical Society Reviews, Год журнала: 2023, Номер 52(16), С. 5607 - 5651

Опубликована: Янв. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Язык: Английский

Процитировано

161
Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments DOI Creative Commons

Markéta Kolaříková,

Barbora Hošíková, Hanna Dilenko

и другие.

Medicinal Research Reviews, Год журнала: 2023, Номер 43(4), С. 717 - 774

Опубликована: Фев. 9, 2023

Abstract Photodynamic therapy is an alternative treatment mainly for cancer but also bacterial infections. This dates back to 1900 when a German medical school graduate Oscar Raab found photodynamic effect while doing research his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, revealed that the toxicity of acridine on paramecium depends intensity light in laboratory. therefore based administration photosensitizer subsequent irradiation within absorption maxima this substance followed by reactive oxygen species formation and finally cell death. Although not novelty, there endeavor various modifications therapy. For example, selectivity efficiency photosensitizer, as well types sources are still being modified improve final results The main aim review summarize anticancer antibacterial modifications, namely compounds, approaches, techniques, enhance effectiveness

Язык: Английский

Процитировано

131
Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy DOI Creative Commons
Liang Zhang, An Song,

Qi‐Chao Yang

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 2, 2023

Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response boosts antitumor immunity. However, the exploration of dual-inducers, particularly nonmetallic inducers, capable triggering both ferroptosis remains limited. Here we show construction a covalent organic framework (COF-919) from planar twisted AIEgen-based motifs dual-inducer for efficient Mechanistic studies reveal that COF-919 displays stronger near-infrared light absorption, lower band energy, longer lifetime to favor generation reactive oxygen species (ROS) photothermal conversion, pyroptosis. Because its good ROS production capability, it upregulates intracellular lipid peroxidation, leading glutathione depletion, low expression peroxidase 4, induction ferroptosis. Additionally, by effectively inhibits tumor metastasis recurrence, resulting in over 90% growth inhibition cure rates exceeding 80%.

Язык: Английский

Процитировано

99
Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response DOI
Mingle Li, Jungryun Kim, Hyeonji Rha

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(11), С. 6007 - 6023

Опубликована: Март 7, 2023

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by release pro-inflammatory cytokines. Our knowledge pyroptosis has expanded beyond cellular level and now includes extracellular responses. In recent years, attracted considerable attention due its potential induce host immunity. For instance, at 2022 International Medicinal Chemistry Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled activation ("PhotoPyro"), emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share Perspective our views on area expound how why "PhotoPyro" could trigger antitumor (i.e., turning so-called "cold" tumors "hot"). doing so, have tried highlight cutting-edge breakthroughs PhotoPyro while suggesting areas future contributions. By providing insights into current state art serving as a resource individuals interested working area, it is hoped that will set stage evolve broadly applicable cancer treatment strategy.

Язык: Английский

Процитировано

89
An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway DOI

Zhenzhen Feng,

Gui Chen,

Min Zhong

и другие.

Biomaterials, Год журнала: 2023, Номер 302, С. 122333 - 122333

Опубликована: Сен. 16, 2023

Язык: Английский

Процитировано

82
Nanozyme-mediated biocatalysis as a mitochondrial oxidative stress amplifier for tumor nanocatalytic immunotherapy DOI

Junya Lu,

Luming Song,

Shuaipeng Feng

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 481, С. 148270 - 148270

Опубликована: Дек. 23, 2023

Язык: Английский

Процитировано

80
An ER‐targeted, Viscosity‐sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway DOI

Shuang Zeng,

Yang Wang, Chen Chen

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)

Опубликована: Янв. 10, 2024

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend modern medical advancement. Herein, we rationally designed smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis treatment in cell animal models by combining hemicyanine dyes ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability target ER a highly specific response viscosity, demonstrated substantial fluorescence turn-on only after binding ER, independent other physiological environments. In addition, ER-ZS, being small molecule, allows nonalcoholic fatty liver disease (NAFLD) via imaging based on high stress. Importantly, is type I photosensitizer, producing O

Язык: Английский

Процитировано

73
Photodynamic therapy combined with immunotherapy: Recent advances and future research directions DOI Creative Commons
Marta Warszyńska, Paweł Repetowski, J. Dąbrowski

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 495, С. 215350 - 215350

Опубликована: Авг. 19, 2023

Innovative anticancer therapies based on the activation of immune system offer promise in battle against cancers resistant to traditional treatments. Examples such therapeutic approaches include, along with various types immunotherapies, photodynamic therapy (PDT). PDT is a photochemistry-based strategy that results not only from its direct effects cancer cells but also disruption tumor vasculature and host system. However, achieve success manifested eradication primary distant metastases, it necessary design suitable photosensitizers (PSs) desired optical photophysical properties enable efficient generation ROS under microenvironmental (TME) conditions, especially hypoxia. Thus, this review particular attention paid photochemical PSs, notably sufficiently long-lived triplet states mechanisms energy/electron transfer reactions. Photogenerated initiate inflammatory reaction, expression heat-shock proteins, infiltration long-term memory. These unique features give new possibilities combine agents stimulating response as well immunotherapy, PD-1/PD-L1 blockade. Most systems explored aspect so far are either derivatives naturally occurring metal complexes (Heme, Chlorophyll a, Bacteiochorophyll - inspired PSs), synthetic (metallo)porphyrins, (metallo)phthalocyanines or hybrid materials containing nanoparticles. This work summarizes recent reports synthesis antibody-PS conjugates spectroscopic enhanced selectivity biological activity. Finally, most notable drawbacks presented, scenario outlined for development alone, combined immunotherapy overcome these challenges future.

Язык: Английский

Процитировано

65
Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example DOI
Qi Meng, Binbin Ding,

Ping’an Ma

и другие.

Small Methods, Год журнала: 2023, Номер 7(5)

Опубликована: Янв. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Язык: Английский

Процитировано

49
A Mild Hyperthermia Hollow Carbon Nanozyme as Pyroptosis Inducer for Boosted Antitumor Immunity DOI
Na Tao, Lei Jiao, Huihuang Li

и другие.

ACS Nano, Год журнала: 2023, Номер 17(22), С. 22844 - 22858

Опубликована: Ноя. 9, 2023

The immune checkpoint blockade (ICB) antibody immunotherapy has demonstrated clinical benefits for multiple cancers. However, the efficacy of in tumors is suppressed by deficient tumor immunogenicity and immunosuppressive microenvironments. Pyroptosis, a form programmed cell death, can release antigens, activate effective immunogenicity, improve efficiency ICB, but efficient pyroptosis treatment currently limited. Herein, we show mild hyperthermia-enhanced pyroptosis-mediated based on hollow carbon nanozyme, which specifically amplify oxidative stress-triggered synchronously magnify anticancer responses microenvironment. sphere modified with iron copper atoms (HCS-FeCu) enzyme-mimicking activities been engineered to induce via radical oxygen species (ROS)-Tom20-Bax-Caspase 3-gasdermin E (GSDME) signaling pathway under light activation. Both vitro vivo antineoplastic results confirm superiority HCS-FeCu nanozyme-induced pyroptosis. Moreover, photothermal-activated combining anti-PD-1 enhance antitumor immunotherapy. Theoretical calculations further indicate that photothermal stimulation generates high-energy electrons enhances interaction between surface adsorbed oxygen, facilitating molecular activation, improves ROS production efficiency. This work presents an approach effectively transforms immunologically "cold" into "hot" ones, significant implications

Язык: Английский

Процитировано

48