Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 242, С. 114074 - 114074
Опубликована: Июль 4, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215560 - 215560
Опубликована: Ноя. 27, 2023
Язык: Английский
Процитировано
54
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Май 7, 2024
Abstract Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer more challenging and may be unresponsive to conventional therapy. Immunotherapy crucial for treating but its resistance a major limitation. tumor microenvironment (TME) vital in modulating immunotherapy response. Various microenvironmental components, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), are involved TME modulation cause resistance. This review highlights role stromal microenvironment, including involvement CAF-TAM interaction, alteration metabolism leading failure, other latest strategies, high throughput genomic screening, single-cell spatial omics techniques identifying immune genes regulating emphasizes therapeutic approach overcome through CAF reprogramming, TAM polarization, metabolism, alterations.
Язык: Английский
Процитировано
44
Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 150154 - 150154
Опубликована: Март 2, 2024
Язык: Английский
Процитировано
12
Journal of drug targeting, Год журнала: 2024, Номер 32(3), С. 287 - 299
Опубликована: Янв. 22, 2024
Carbon nanotubes (CNTs) are allotropes of carbon, composed carbon atoms forming a tube-like structure. Their high surface area, chemical stability, and rich electronic polyaromatic structure facilitate their drug-carrying capacity. Therefore, CNTs have been intensively explored for several biomedical applications, including as potential treatment option cancer. By incorporating smart fabrication strategies, can be designed to specifically target cancer cells. This targeted drug delivery approach not only maximizes the therapeutic utility but also minimizes any side effects free molecules. utilised photothermal therapy (PTT) which uses photosensitizers generate reactive oxygen species (ROS) kill cells, in immunotherapeutic applications. Regarding latter, example, CNT-based formulations preferentially intra-tumoural regulatory T-cells. act efficient antigen presenters. With capabilities photoacoustic, fluorescent Raman imaging, excellent diagnostic tools well. Further, metallic nanoparticles, such gold or silver combined with create nanobiosensors measure biological reactions. review focuses on current knowledge about theranostic CNT, challenges associated large-scale production, possible important parameters consider when exploring clinical usage.
Язык: Английский
Процитировано
11
Advanced Science, Год журнала: 2024, Номер 11(26)
Опубликована: Май 6, 2024
Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356) for synergistic SDT/immunotherapy. Specifically, a‐CoW‐LDH act as sonosensitizer generate abundant reactive oxygen species (ROS) under US irradiation. After loading a‐LDH@356 plus irradiation not only effectively induces ROS generation immunogenic death, but also inhibits elevation citrullinated histone H3 (H3cit) release NETs, enabling enhancement anti‐tumor metastasis effect. Using 4T1 model, it that combining YW3‐56 stimulates an by upregulating proportion immune‐activated cells inducing polarization M1 macrophages, escape downregulating expression PD‐1 on irradiation, which arrests primary progression inhibition rate 69.5% prevents least number lung nodules.
Язык: Английский
Процитировано
10
Dyes and Pigments, Год журнала: 2024, Номер 229, С. 112262 - 112262
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
10
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
10
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 2, 2025
Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within tumor microenvironment (TME) following therapy (PDT). In this study, we report design guidelines towards efficient Type-I semiconducting polymer photosensitizer modify best-performing into hypoxia-tolerant polymeric prodrug (HTPSNiclo) for cancer photo-immunotherapy. HTPSNiclo not only performs PDT process to partially overcome limitation of hypoxic tumors in recycling oxygen but also specifically releases Signal Transducer Activator Transcription-3 (STAT3) inhibitor (Niclosamide) response biomarker TME. Consequently, inhibits phosphorylation STAT3, suppresses expression hypoxia-inducible factor-1α. The synergistic effect results enhanced activation immune cells (including mature dendritic cells, cytotoxic T cells) production immunostimulatory cytokines compared alone. Thus, HTPSNiclo-mediated enhances inhibition rate from 75.53% 91.23%, prolongs 100% survival 39 days 60 as This study provides generic polymer-based photosensitizers uncovers effective strategies counteract TME photo-immunotherapy 4T1 bearing female BALB/c mice. Photodynamic therapy, microenvironment. Here, authors development
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
The tumor-specific efficacy of the most current anticancer therapeutic agents, including antibody-drug conjugates (ADCs), oligonucleotides, and photosensitizers, is constrained by limitations such as poor cell penetration low drug delivery. In this study, we addressed these challenges developing, a positively charged, amphiphilic Chlorin e6 (Ce6)-conjugated, cell-penetrating anti-PD-L1 peptide nanomedicine (CPPD1) with enhanced tissue permeability. CPPD1 molecule, bioconjugate hydrophobic photosensitizer strongly charged programmed death-ligand 1 (PD-L1) binding (CPP), capable self-assembling into nanoparticles an average size 199 nm in aqueous solution without need for any carriers. These carrier-free possess ability to penetrate membrane cancer cells target tumors expressing PD-L1 on their surface. Notably, effectively blocked death-1 (PD-1)/PD-L1 interactions reduced expression via lysosomal degradation. They also demonstrated responsiveness photodynamic therapy (PDT) 635 laser, leading generation ROS, induction various immunogenic deaths (ICD). Highly penetrating could immunogenically modulate microenvironment CT26 were effective treating abscopal metastatic tumors, addressing major traditional PDT.
Язык: Английский
Процитировано
1
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 69 - 69
Опубликована: Янв. 21, 2025
Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.
Язык: Английский
Процитировано
1