Macromolecular Bioscience,
Год журнала:
2023,
Номер
23(11)
Опубликована: Июнь 2, 2023
Abstract
Bacterial
adhesion
and
subsequent
biofilm
formation
on
the
surfaces
of
synthetic
materials
imposes
a
significant
burden
in
various
fields,
which
can
lead
to
infections
patients
or
reduce
service
life
industrial
devices.
Therefore,
there
is
increasing
interest
imbuing
with
antibacterial
properties.
Bioinspired
superhydrophobic
high
water
contact
angles
(>150°)
exhibit
excellent
surface
repellency
against
contaminations,
thereby
preventing
initial
bacterial
inhibiting
formation.
However,
conventional
typically
lack
long‐term
durability
are
incapable
achieving
persistent
efficacy
adhesion.
To
overcome
these
limitations,
recent
decades,
dual‐function
both
bacteria‐repelling
bacteria‐killing
properties
have
been
developed
by
introducing
bactericidal
components.
These
demonstrated
improved
performance
addressing
issues
associated
surface‐attached
bacteria.
This
review
summarizes
advancements
surfaces.
First,
brief
overview
fabrication
strategies
mechanism
provided
then
classified
into
three
types
based
mechanism:
i)
mechanotherapy,
ii)
chemotherapy,
iii)
phototherapy.
Finally,
limitations
challenges
current
research
discussed
future
perspectives
this
promising
area
proposed.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 31, 2023
Antimicrobial
photodynamic
therapy
(aPDT)
has
become
a
potent
contender
in
the
fight
against
microbial
infections,
especially
context
of
rising
antibiotic
resistance
crisis.
Recently,
there
been
significant
interest
polyphenolic
natural
products
as
potential
photosensitizers
(PSs)
aPDT,
given
their
unique
chemical
structures
and
inherent
antimicrobial
properties.
Polyphenolic
products,
abundant
readily
obtainable
from
sources,
are
generally
regarded
safe
highly
compatible
with
human
body.
This
comprehensive
review
focuses
on
latest
developments
future
implications
using
polyphenols
PSs
aPDT.
Paramount
compounds,
including
curcumin,
hypericin,
quercetin,
hypocrellin,
celastrol,
riboflavin,
resveratrol,
gallic
acid,
aloe
emodin,
elaborated
upon
respect
to
structural
characteristics,
absorption
properties,
effects.
Furthermore,
aPDT
mechanism,
specifically
its
targeted
action
cells
biofilms,
is
also
discussed.
demonstrate
immense
representing
promising
alternate
approach
counteract
antibiotic-resistant
bacteria
biofilm-related
infections.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(19), С. 22985 - 22998
Опубликована: Май 8, 2023
Bacterial-induced
infectious
diseases
have
always
caused
an
unavoidable
problem
and
lead
to
increasing
threat
human
health.
Hence,
there
is
urgent
need
for
effective
antibacterial
strategies
treat
diseases.
Current
methods
are
often
ineffective
require
large
amounts
of
hydrogen
peroxide
(H2O2),
with
harmful
effects
on
normal
healthy
tissue.
Chemodynamic
therapy
(CDT)
provides
ideal
infection
microenvironment
(IME)-activated
paradigm
tackle
bacterial-related
To
take
full
advantage
the
specificity
IME
enhanced
CDT
wounds
bacterial
infection,
we
designed
intelligent
system
that
exploits
nanocatalytic
ZIF-67@Ag2O2
nanosheets.
In
this
system,
silver
nanoparticles
(Ag2O2
NPs)
were
grown
ultrathin
zeolitic
imidazolate
framework-67
(ZIF-67)
nanosheets
by
in
situ
oxidation,
then,
ability
self-generate
H2O2
triggered
mildly
acidic
environment
IME.
Lamellar
ZIF-67
shown
rapidly
degrade
release
Co2+,
allowing
conversion
less
reactive
into
highly
toxic
oxygen
species
hydroxyl
radicals
(•OH)
properties.
vivo
results
revealed
nanosheet
exhibits
excellent
performance
against
both
Gram-positive
(Staphylococcus
aureus)
Gram-negative
(Escherichia
coli)
bacteria.
The
proposed
hybrid
strategy
demonstrates
a
promising
therapeutic
enable
agents
IME-responsive
activity
circumvent
antibiotic
resistance
infections.
Macromolecular Bioscience,
Год журнала:
2023,
Номер
23(11)
Опубликована: Июнь 2, 2023
Abstract
Bacterial
adhesion
and
subsequent
biofilm
formation
on
the
surfaces
of
synthetic
materials
imposes
a
significant
burden
in
various
fields,
which
can
lead
to
infections
patients
or
reduce
service
life
industrial
devices.
Therefore,
there
is
increasing
interest
imbuing
with
antibacterial
properties.
Bioinspired
superhydrophobic
high
water
contact
angles
(>150°)
exhibit
excellent
surface
repellency
against
contaminations,
thereby
preventing
initial
bacterial
inhibiting
formation.
However,
conventional
typically
lack
long‐term
durability
are
incapable
achieving
persistent
efficacy
adhesion.
To
overcome
these
limitations,
recent
decades,
dual‐function
both
bacteria‐repelling
bacteria‐killing
properties
have
been
developed
by
introducing
bactericidal
components.
These
demonstrated
improved
performance
addressing
issues
associated
surface‐attached
bacteria.
This
review
summarizes
advancements
surfaces.
First,
brief
overview
fabrication
strategies
mechanism
provided
then
classified
into
three
types
based
mechanism:
i)
mechanotherapy,
ii)
chemotherapy,
iii)
phototherapy.
Finally,
limitations
challenges
current
research
discussed
future
perspectives
this
promising
area
proposed.
