CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(9), С. 10998 - 11007

Опубликована: Апрель 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Язык: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Язык: Английский

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H2O2 self-supplied CuFeOx nanosystem as fenton-like reaction agents for endogenous/exogenous responsive synergetic antibacterial therapy

Chemical Engineering Journal, Год журнала: 2024, Номер 492, С. 152265 - 152265

Опубликована: Май 15, 2024

Язык: Английский

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Acidic biofilm microenvironment-responsive ROS generation via a protein nanoassembly with hypoxia-relieving and GSH-depleting capabilities for efficient elimination of biofilm bacteria

Acta Biomaterialia, Год журнала: 2024, Номер 186, С. 439 - 453

Опубликована: Авг. 2, 2024

Язык: Английский

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A self-supplied hydrogen peroxide and nitric oxide-generating nanoplatform enhances the efficacy of chemodynamic therapy for biofilm eradication

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 20 - 29

Опубликована: Авг. 22, 2024

Язык: Английский

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One-pot assembly of gold nanoparticles in different dimensional MOFs with peroxidase-like activity for enhanced bacterial eradication

Materials & Design, Год журнала: 2024, Номер 239, С. 112804 - 112804

Опубликована: Фев. 28, 2024

Bacterially infected wounds are a hidden danger to human health, and the elimination of invasive wound bacteria is critical for proper healing. Nanozymes with peroxidase (POD)-like catalase (CAT)-like activities serve as promising antimicrobial agents since they avoid damage caused by high concentrations hydrogen peroxide (H2O2) while providing sufficient oxygen (O2). Herein, we report hybrid composites gold nanoparticles (AuNPs) assembled on two-dimensional or three-dimensional (2D/3D) Zn-based metal organic frameworks (Zn-MOFs) via free amino groups. Specifically, formed 3D Zn-MOF@Au, which combines advantages AuNPs stabilized MOFs, exhibits more significant POD-like activity in terms decomposing H2O2 into toxic hydroxyl radicals than 2D Zn-MOF@Au being able supply O2. We performed systematic tests against using this composite nanomaterial different dimensions, results showed that had better antibacterial effects gram-positive (methicillin-resistant Staphylococcus aureus, MRSA) gram-negative (Escherichia coli, E. coli) addition low dose H2O2. Animal experiments effectively accelerated bacteria-infected healing excellent biocompatibility. This study demonstrated great promise modified dimensional MOFs therapy applications.

Язык: Английский

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Engineering H₂O₂ Self-Supplying Platform for Xdynamic Therapies via Ru–Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(19), С. 24172 - 24190

Опубликована: Апрель 30, 2024

Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in tumor microenvironment (TME) are main barriers to advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial chemodynamic therapy (CDT), yet endogenous levels not sufficient attain better anticancer efficacy. Specifically, there a need amplify reactivity within tumors, leveraging unique attributes TME. Herein, for first time, we design RuxCu1–xO2–Ce6/CPT (RCpCCPT) nanoagent TME-mediated synergistic based on heterogeneous Ru–Cu peroxide nanodots (RuxCu1–xO2 NDs) chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The NDs (RCp NDs, x 0.50) possess highest vacancy (OV) density, which grants them potential form massive Lewis's acid sites adsorption, while dispersibility targetability were improved via surface modification using hyaluronic (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, Cu+/2+ ions, cooperatively facilitate hydroxyl radical (•OH) formation deactivate antioxidant GSH enzymes through cocatalytic loop, resulting excellent therapeutic Furthermore, when combined laser treatment, produces singlet (1O2) PDT, induces cell apoptosis at sites. Following ROS generation, TK linkage disrupted, up 92% CPT 48 h. vitro investigations showed that laser-treated caused 81.5% death from PDT/CDT chemotherapy (CT). cancer cells red-blue emission images taking in, allows fluorescence image-guided treatment. overall results show RCp more biocompatible have effectiveness vivo.

Язык: Английский

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Infection microenvironment-triggered nanoparticles eradicate MRSA by thermally amplified chemodynamic therapy and M1 macrophage

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 30, 2024

Abstract It is of great significance to develop a novel approach treat bacterial infections, as the frequent misuse antibiotics leads serious problem resistance. This study proposed antibiotic-free antibacterial nanoparticles for eliminating methicillin-resistant Staphylococcus aureus (MRSA) based on multi-model synergistic ability chemodynamic therapy (CDT), photothermal effect, and innate immunomodulation. Specifically, polydopamine (PDA) layer coated Ag loaded core-shell structure Fe 3 O 4 (Fe @PDA-Ag) prepared. The catalyzes H 2 present in acidic microenvironment infection into more toxic reactive oxygen species (ROS) synergizes with released ions exert stronger bactericidal capacity, which can be augmented by action PDA triggered near-infrared light loosen biofilm promote penetration ROS ion biofilm, result disrupting along killing encapsulated bacteria. Furthermore, @PDA-Ag exerts indirect effects promoting M1 macrophage polarizing. Animal models demonstrated that effectively controlled MRSA-induced infections through enhanced CDT, + releasing, macrophage-mediated properties. acid-triggered are expected combat drug-resistant bacteria infection. Graphical abstract

Язык: Английский

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Zinc Cerium Peroxide Antibacterial Agent with Acid-Activated Cascade Multienzymatic Activities

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Recently, metal peroxides with the ability to self-supply H2O2 have been intensively used in antibacterial and cancer therapy. However, performances are unsatisfactory due low efficiency of peroxide-mediated Fenton-like reaction. In this work, a novel zinc cerium bimetallic peroxide (CeZnOx) has first reported, which possesses acid-activated POD-like, OXD-like, CAT-like multienzymatic activities for efficiently bacterial inhibition. Specifically, CeZnOx self-supplying under weakly acidic conditions subsequently catalyzes production reactive oxygen species (ROS) through synergistically enhanced POD-like OXD-like activity. They can also exhibit activity catalyze excessive into O2 play an anti-inflammatory role normal pH conditions. The cascade inhibit growth alleviate hypoxia, improving microenvironment at wound site. As expected, exhibits superior effect on Staphylococcus aureus Escherichia coli. Therefore, CeZnOx-mediated offer simple promising strategy efficient treatment infections.

Язык: Английский

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Group IB Metal‐Based Nanomaterials for Antibacterial Applications

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Март 9, 2025

Pathogenic bacteria pose significant threats to human health. In recent years, escalating bacterial resistance against antibiotics has diminished their efficacy in treating infections like pneumonia, tuberculosis, and sepsis, making some cases virtually untreatable. Hence, there is an urgent demand for novel approaches combat threats. Group IB metal‐based nanomaterials including copper, silver, gold have attracted considerable attention the field of antibacterial research owing remarkable broad‐spectrum bactericidal properties. Their high efficacy, ease synthesis, amenability functionalization render group highly promising diverse applications domain. This review comprehensively elucidates on mechanisms IB‐group addressing infections. Additionally, insights into challenges associated with utilizing such purposes while outlining future directions are provided.

Язык: Английский

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