Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies DOI

Xiangrong Zhao,

Meilin Yao, Yuyi Wang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

The skeleton is highly innervated by numerous nerve fibers. These fibers, in addition to transmitting information within the bone and mediating sensations, play a crucial role regulating tissue formation regeneration. Traditional engineering (BTE) often fails achieve satisfactory outcomes when dealing with large-scale defects, which frequently related lack of effective reconstruction neurovascular network. In recent years, increasing research has revealed critical nerves metabolism. Nerve fibers regulate cells through neurotransmitters, neuropeptides, peripheral glial cells. Furthermore, also coordinate vascular immune systems jointly construct microenvironment favorable for As signaling driver formation, neuroregulation spans entire process physiological activities from embryonic postmaturity remodeling repair. However, there currently comprehensive summaries these regulatory mechanisms. Therefore, this review sketches out function during Then, we elaborate on mechanisms coupling neuromodulation immunity. Finally, discuss several novel strategies neuro-bone (NBTE) based bone, focusing coordinated regeneration tissue.

Язык: Английский

3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering DOI Creative Commons
Annan Chen, Jin Su,

Yinjin Li

и другие.

International Journal of Extreme Manufacturing, Год журнала: 2023, Номер 5(3), С. 032007 - 032007

Опубликована: Май 24, 2023

Abstract Piezoelectricity in native bones has been well recognized as the key factor bone regeneration. Thus, bio-piezoelectric materials have gained substantial attention repairing damaged by mimicking tissue’s electrical microenvironment (EM). However, traditional manufacturing strategies still encounter limitations creating personalized scaffolds, hindering their clinical applications. Three-dimensional (3D)/four-dimensional (4D) printing technology based on principle of layer-by-layer forming and stacking discrete demonstrated outstanding advantages fabricating scaffolds a more complex-shaped structure. Notably, 4D functionality-shifting can provide time-dependent programmable tissue EM response to external stimuli for In this review, we first summarize physicochemical properties commonly used (including polymers, ceramics, composites) representative biological findings Then, discuss latest research advances 3D terms feedstock selection, process, induction strategies, potential Besides, some related challenges such scalability, resolution, stress-to-polarization conversion efficiency, non-invasive ability after implantation put forward. Finally, highlight shape/property/functionality-shifting smart engineering (BTE). Taken together, review emphasizes appealing utility 3D/4D printed piezoelectric next-generation BTE implants.

Язык: Английский

Процитировано

93

Magnesium Gradient‐Based Hierarchical Scaffold for Dual‐Lineage Regeneration of Osteochondral Defect DOI
Chenyuan Gao, Wenli Dai, Xinyu Wang

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(43)

Опубликована: Июль 2, 2023

Abstract Osteochondral regeneration remains a great challenge due to the limited self‐healing ability and complexity of its hierarchical structure composition. Mg 2+ hypoxia are two effective modulators in boosting chondrogenesis. To this end, double‐layered scaffold (D) consisting hydrogel layer on porous cryogel is fabricated mimic osteochondral tissue. An gradient incorporated into with hypoxia‐mimicking deferoxamine (DFO) embedded (D‐Mg‐DFO), which remarkably augments dual‐lineage both cartilage subchondral bone. The higher supplementation from upper hydrogel, associated situation small pore size, exhibits promotive effects chondrogenic differentiation. lower bottom cryogel, interconnected macroporous structure, achieves multiple contributions stem cell migration bone marrow cavity, matrix mineralization, osteogenesis. Furthermore, rabbits’ trochlea defects established evaluate regenerative outcome. Compared control scaffolds containing only or DFO, D‐Mg‐DFO presents best effect under synergistic contribution factors. Overall, work provides new design toward an repair defect.

Язык: Английский

Процитировано

65

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration DOI
Li Chen,

Jianye Yang,

Zhengwei Cai

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Янв. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Язык: Английский

Процитировано

27

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives DOI Creative Commons
Yubin Yao, Xi Cui, Shenglong Ding

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.

Язык: Английский

Процитировано

4

Strategies for promoting neurovascularization in bone regeneration DOI Creative Commons
Xinling Li, Yuqing Zhao, Miao Li

и другие.

Military Medical Research, Год журнала: 2025, Номер 12(1)

Опубликована: Март 3, 2025

Abstract Bone tissue relies on the intricate interplay between blood vessels and nerve fibers, both are essential for many physiological pathological processes of skeletal system. Blood provide necessary oxygen nutrients to bone tissues, remove metabolic waste. Concomitantly, fibers precede during growth, promote vascularization, influence cells by secreting neurotransmitters stimulate osteogenesis. Despite critical roles components, current biomaterials generally focus enhancing intraosseous vessel repair, while often neglecting contribution nerves. Understanding distribution main functions in is crucial developing effective engineering. This review first explores anatomy highlighting their vital embryonic development, metabolism, repair. It covers innovative regeneration strategies directed at accelerating intrabony neurovascular system over past 10 years. The issues covered included material properties (stiffness, surface topography, pore structures, conductivity, piezoelectricity) acellular biological factors [neurotrophins, peptides, ribonucleic acids (RNAs), inorganic ions, exosomes]. Major challenges encountered neurovascularized materials clinical translation have also been highlighted. Furthermore, discusses future research directions potential developments aimed producing repair that more accurately mimic natural healing tissue. will serve as a valuable reference researchers clinicians novel into practice. By bridging gap experimental practical application, these advancements transform treatment defects significantly improve quality life patients with bone-related conditions.

Язык: Английский

Процитировано

3

Versatile application of magnesium-related bone implants in the treatment of bone defects DOI Creative Commons
Min Tao, Yutao Cui, Shicai Sun

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101635 - 101635

Опубликована: Март 5, 2025

Magnesium-related bone implants have garnered significant attention in the treatment of defects. The applications magnesium promoting repair mainly include degradable magnesium-based scaffolds owing to its special physical properties and composite materials modified by ions because biological activity. Although numerous studies confirmed unique application advantages efficacy repair, some obvious shortcomings persist, including rapid degradation scaffolds. In this review, deficiencies alloys construction orthopedic their key influencing factors were summarized; furthermore, advanced improvement schemes summarized analyzed. Additionally, strategies magnesium-modified are discussed. Lastly, review incorporates latest research discoveries on science, comprehensively exploring mechanism magnesium's role complex microenvironment defects from multiple dimensions. This paper provides a comprehensive summary analysis cutting-edge concepts design development implants, considering various perspectives such as functions magnesium.

Язык: Английский

Процитировано

2

3D printing for bone repair: Coupling infection therapy and defect regeneration DOI

Jiatian Chen,

Huaijuan Zhou, Yingwei Fan

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 471, С. 144537 - 144537

Опубликована: Июнь 30, 2023

Язык: Английский

Процитировано

41

Microenvironment-targeted strategy steers advanced bone regeneration DOI Creative Commons

Shuyue Hao,

Mingkai Wang,

Zhifeng Yin

и другие.

Materials Today Bio, Год журнала: 2023, Номер 22, С. 100741 - 100741

Опубликована: Июль 20, 2023

Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Traditional strategies tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) terms structure composition. However, synergistic effects other cues from microenvironment during regeneration are often neglected. The is sophisticated system that includes physiological (e.g., neighboring cells such as macrophages), chemical oxygen, pH), physical factors mechanics, acoustics) dynamically interact with each other. Microenvironment-targeted increasingly recognized crucial for successful offer promising solutions advancing engineering. This review provides comprehensive overview current microenvironment-targeted challenges further outlines prospective directions approaches construction organoids.

Язык: Английский

Процитировано

31

Fibrous dressing containing bioactive glass with combined chemotherapy and wound healing promotion for post-surgical treatment of melanoma DOI

Caini Yuan,

Daixing Zhang,

Yujing Tang

и другие.

Biomaterials Advances, Год журнала: 2023, Номер 149, С. 213387 - 213387

Опубликована: Март 16, 2023

Язык: Английский

Процитировано

25

Biomimetic bone-periosteum scaffold for spatiotemporal regulated innervated bone regeneration and therapy of osteosarcoma DOI Creative Commons
Yan Xu, Chao Xu, Huan Song

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 15, 2024

The complexity of repairing large segment defects and eradicating residual tumor cell puts the osteosarcoma clinical management challenging. Current biomaterial design often overlooks crucial role precisely regulating innervation in bone regeneration. Here, we develop a Germanium Selenium (GeSe) co-doped polylactic acid (PLA) nanofiber membrane-coated tricalcium phosphate bioceramic scaffold (TCP-PLA/GeSe) that mimics bone-periosteum structure. This biomimetic offers dual functionality, combining piezoelectric photothermal conversion capabilities while remaining biodegradable. When subjected to ultrasound irradiation, US-electric stimulation TCP-PLA/GeSe enables spatiotemporal control neurogenic differentiation. feature supports early during formation, promoting differentiation Schwann cells (SCs) by increasing intracellular Ca

Язык: Английский

Процитировано

18