ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
skeleton
is
highly
innervated
by
numerous
nerve
fibers.
These
fibers,
in
addition
to
transmitting
information
within
the
bone
and
mediating
sensations,
play
a
crucial
role
regulating
tissue
formation
regeneration.
Traditional
engineering
(BTE)
often
fails
achieve
satisfactory
outcomes
when
dealing
with
large-scale
defects,
which
frequently
related
lack
of
effective
reconstruction
neurovascular
network.
In
recent
years,
increasing
research
has
revealed
critical
nerves
metabolism.
Nerve
fibers
regulate
cells
through
neurotransmitters,
neuropeptides,
peripheral
glial
cells.
Furthermore,
also
coordinate
vascular
immune
systems
jointly
construct
microenvironment
favorable
for
As
signaling
driver
formation,
neuroregulation
spans
entire
process
physiological
activities
from
embryonic
postmaturity
remodeling
repair.
However,
there
currently
comprehensive
summaries
these
regulatory
mechanisms.
Therefore,
this
review
sketches
out
function
during
Then,
we
elaborate
on
mechanisms
coupling
neuromodulation
immunity.
Finally,
discuss
several
novel
strategies
neuro-bone
(NBTE)
based
bone,
focusing
coordinated
regeneration
tissue.
International Journal of Extreme Manufacturing,
Год журнала:
2023,
Номер
5(3), С. 032007 - 032007
Опубликована: Май 24, 2023
Abstract
Piezoelectricity
in
native
bones
has
been
well
recognized
as
the
key
factor
bone
regeneration.
Thus,
bio-piezoelectric
materials
have
gained
substantial
attention
repairing
damaged
by
mimicking
tissue’s
electrical
microenvironment
(EM).
However,
traditional
manufacturing
strategies
still
encounter
limitations
creating
personalized
scaffolds,
hindering
their
clinical
applications.
Three-dimensional
(3D)/four-dimensional
(4D)
printing
technology
based
on
principle
of
layer-by-layer
forming
and
stacking
discrete
demonstrated
outstanding
advantages
fabricating
scaffolds
a
more
complex-shaped
structure.
Notably,
4D
functionality-shifting
can
provide
time-dependent
programmable
tissue
EM
response
to
external
stimuli
for
In
this
review,
we
first
summarize
physicochemical
properties
commonly
used
(including
polymers,
ceramics,
composites)
representative
biological
findings
Then,
discuss
latest
research
advances
3D
terms
feedstock
selection,
process,
induction
strategies,
potential
Besides,
some
related
challenges
such
scalability,
resolution,
stress-to-polarization
conversion
efficiency,
non-invasive
ability
after
implantation
put
forward.
Finally,
highlight
shape/property/functionality-shifting
smart
engineering
(BTE).
Taken
together,
review
emphasizes
appealing
utility
3D/4D
printed
piezoelectric
next-generation
BTE
implants.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(43)
Опубликована: Июль 2, 2023
Abstract
Osteochondral
regeneration
remains
a
great
challenge
due
to
the
limited
self‐healing
ability
and
complexity
of
its
hierarchical
structure
composition.
Mg
2+
hypoxia
are
two
effective
modulators
in
boosting
chondrogenesis.
To
this
end,
double‐layered
scaffold
(D)
consisting
hydrogel
layer
on
porous
cryogel
is
fabricated
mimic
osteochondral
tissue.
An
gradient
incorporated
into
with
hypoxia‐mimicking
deferoxamine
(DFO)
embedded
(D‐Mg‐DFO),
which
remarkably
augments
dual‐lineage
both
cartilage
subchondral
bone.
The
higher
supplementation
from
upper
hydrogel,
associated
situation
small
pore
size,
exhibits
promotive
effects
chondrogenic
differentiation.
lower
bottom
cryogel,
interconnected
macroporous
structure,
achieves
multiple
contributions
stem
cell
migration
bone
marrow
cavity,
matrix
mineralization,
osteogenesis.
Furthermore,
rabbits’
trochlea
defects
established
evaluate
regenerative
outcome.
Compared
control
scaffolds
containing
only
or
DFO,
D‐Mg‐DFO
presents
best
effect
under
synergistic
contribution
factors.
Overall,
work
provides
new
design
toward
an
repair
defect.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Янв. 7, 2024
Abstract
The
incidence
of
large
bone
and
articular
cartilage
defects
caused
by
traumatic
injury
is
increasing
worldwide;
the
tissue
regeneration
process
for
these
injuries
lengthy
due
to
limited
self‐healing
ability.
Endogenous
bioelectrical
phenomenon
has
been
well
recognized
play
an
important
role
in
homeostasis
regeneration.
Studies
have
reported
that
electrical
stimulation
(ES)
can
effectively
regulate
various
biological
processes
holds
promise
as
external
intervention
enhance
synthesis
extracellular
matrix,
thereby
accelerating
Hence,
electroactive
biomaterials
considered
a
biomimetic
approach
ensure
functional
recovery
integrating
physiological
signals,
including
electrical,
biochemical,
mechanical
signals.
This
review
will
discuss
endogenous
bioelectricity
tissue,
effects
ES
on
cellular
behaviors.
Then,
recent
advances
materials
their
applications
are
systematically
overviewed,
with
focus
advantages
disadvantages
repair
performances
modulation
cell
fate.
Finally,
significance
mimicking
electrophysiological
microenvironment
target
emphasized
future
development
challenges
strategies
proposed.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Severe
bone
and
cartilage
defects
caused
by
trauma
are
challenging
to
treat,
often
resulting
in
poor
outcomes.
An
endogenous
electric
field
(EnEF)
is
crucial
for
regeneration,
making
electrical
materials
a
promising
therapy.
This
review
provides
comprehensive
overview
of
the
role
bioelectric
signals
cells,
alongside
recent
advancements
biomaterials,
with
particular
emphasis
on
nanogenerators,
piezoelectric
materials,
triboelectric
scaffolds,
zwitterionic
hydrogels.
It
further
investigates
impact
these
biomaterials
as
well
applications
both
exogenous
stimulation
(ES)
mechanisms
underlying
ES‐induced
cellular
molecular
responses.
Finally,
underscores
future
directions
ES
systems
tissue
engineering,
emphasizing
critical
importance
integrating
structural
integrity,
mechanical
properties,
signal
delivery
into
intelligent
implantable
scaffolds.
Military Medical Research,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101635 - 101635
Опубликована: Март 5, 2025
Magnesium-related
bone
implants
have
garnered
significant
attention
in
the
treatment
of
defects.
The
applications
magnesium
promoting
repair
mainly
include
degradable
magnesium-based
scaffolds
owing
to
its
special
physical
properties
and
composite
materials
modified
by
ions
because
biological
activity.
Although
numerous
studies
confirmed
unique
application
advantages
efficacy
repair,
some
obvious
shortcomings
persist,
including
rapid
degradation
scaffolds.
In
this
review,
deficiencies
alloys
construction
orthopedic
their
key
influencing
factors
were
summarized;
furthermore,
advanced
improvement
schemes
summarized
analyzed.
Additionally,
strategies
magnesium-modified
are
discussed.
Lastly,
review
incorporates
latest
research
discoveries
on
science,
comprehensively
exploring
mechanism
magnesium's
role
complex
microenvironment
defects
from
multiple
dimensions.
This
paper
provides
a
comprehensive
summary
analysis
cutting-edge
concepts
design
development
implants,
considering
various
perspectives
such
as
functions
magnesium.
Materials Today Bio,
Год журнала:
2023,
Номер
22, С. 100741 - 100741
Опубликована: Июль 20, 2023
Treatment
of
large
bone
defects
represents
a
great
challenge
in
orthopedic
and
craniomaxillofacial
surgery.
Traditional
strategies
tissue
engineering
have
focused
primarily
on
mimicking
the
extracellular
matrix
(ECM)
terms
structure
composition.
However,
synergistic
effects
other
cues
from
microenvironment
during
regeneration
are
often
neglected.
The
is
sophisticated
system
that
includes
physiological
(e.g.,
neighboring
cells
such
as
macrophages),
chemical
oxygen,
pH),
physical
factors
mechanics,
acoustics)
dynamically
interact
with
each
other.
Microenvironment-targeted
increasingly
recognized
crucial
for
successful
offer
promising
solutions
advancing
engineering.
This
review
provides
comprehensive
overview
current
microenvironment-targeted
challenges
further
outlines
prospective
directions
approaches
construction
organoids.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 15, 2024
The
complexity
of
repairing
large
segment
defects
and
eradicating
residual
tumor
cell
puts
the
osteosarcoma
clinical
management
challenging.
Current
biomaterial
design
often
overlooks
crucial
role
precisely
regulating
innervation
in
bone
regeneration.
Here,
we
develop
a
Germanium
Selenium
(GeSe)
co-doped
polylactic
acid
(PLA)
nanofiber
membrane-coated
tricalcium
phosphate
bioceramic
scaffold
(TCP-PLA/GeSe)
that
mimics
bone-periosteum
structure.
This
biomimetic
offers
dual
functionality,
combining
piezoelectric
photothermal
conversion
capabilities
while
remaining
biodegradable.
When
subjected
to
ultrasound
irradiation,
US-electric
stimulation
TCP-PLA/GeSe
enables
spatiotemporal
control
neurogenic
differentiation.
feature
supports
early
during
formation,
promoting
differentiation
Schwann
cells
(SCs)
by
increasing
intracellular
Ca
