BioMedical Engineering OnLine,
Год журнала:
2025,
Номер
24(1)
Опубликована: Апрель 30, 2025
The
treatment
of
large
bone
defects
remains
a
significant
clinical
challenge
due
to
the
limitations
current
grafting
techniques,
including
donor
site
morbidity,
restricted
availability,
and
suboptimal
integration.
Recent
advances
in
3D
bioprinting
technology
have
enabled
fabrication
structurally
functionally
optimized
scaffolds
that
closely
mimic
native
tissue
architecture.
This
review
comprehensively
examines
latest
developments
3D-printed
for
regeneration,
focusing
on
three
critical
aspects:
(1)
material
selection
composite
design
encompassing
metallic;
(2)
structural
optimization
with
hierarchical
porosity
(macro/micro/nano-scale)
biomechanical
properties
tailored;
(3)
biological
functionalization
through
growth
factor
delivery,
cell
seeding
strategies
surface
modifications.
We
critically
analyze
scaffold
performance
metrics
from
different
research
applications,
while
discussing
translational
barriers,
vascular
network
establishment,
mechanical
stability
under
load-bearing
conditions,
manufacturing
scalability.
concludes
forward-looking
perspective
innovative
approaches
such
as
4D
dynamic
scaffolds,
smart
biomaterials
stimuli-responsive
properties,
integration
artificial
intelligence
patient-specific
optimization.
These
technological
advancements
collectively
offer
unprecedented
opportunities
address
unmet
needs
complex
reconstruction.
Theranostics,
Год журнала:
2023,
Номер
13(6), С. 2015 - 2039
Опубликована: Янв. 1, 2023
Increasing
data
reveals
that
gelatin
has
been
methacrylated
is
involved
in
a
variety
of
physiologic
processes
are
important
for
therapeutic
interventions.
Gelatin
methacryloyl
(GelMA)
hydrogel
highly
attractive
hydrogels-based
bioink
because
its
good
biocompatibility,
low
cost,
and
photo-cross-linking
structure
useful
cell
survivability
monitoring.
Methacrylated
established
itself
as
typical
composition
with
extensive
biomedical
applications.
Recent
advances
GelMA
have
focused
on
integrating
them
bioactive
functional
nanomaterials,
the
goal
improving
GelMA's
physical,
chemical,
biological
properties.
ability
to
modify
characteristics
due
synthesis
technique
also
makes
it
choice
soft
hard
tissues.
become
an
independent
or
supplementary
technology
musculoskeletal
problems.
Here,
we
systematically
review
mechanism-of-action,
uses,
challenges
future
direction
disorders.
We
give
overview
nanocomposite
different
applications
disorders,
such
osteoarthritis,
intervertebral
disc
degeneration,
bone
regeneration,
tendon
disorders
so
on.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 17, 2024
Abstract
Background
The
transplantation
of
exosomes
derived
from
human
adipose-derived
mesenchymal
stem
cells
(hADSCs)
has
emerged
as
a
prospective
cellular-free
therapeutic
intervention
for
the
treatment
neurodevelopmental
disorders
(NDDs),
well
autism
spectrum
disorder
(ASD).
Nevertheless,
efficacy
hADSC
exosome
ASD
remains
to
be
verified,
and
underlying
mechanism
action
unclear.
Results
exosomal
long
non-coding
RNAs
(lncRNAs)
umbilical
cord
(hUCMSC)
were
sequenced
13,915
729
lncRNAs
obtained,
respectively.
present
in
hADSC-Exos
encompass
those
found
hUCMSC-Exos
are
associated
with
neurogenesis.
biodistribution
mouse
brain
ventricles
organoids
was
tracked,
cellular
uptake
evaluated
both
vivo
vitro.
promote
neurogenesis
organoid
ameliorate
social
deficits
model
BTBR
T
+
tf/J
(BTBR).
Fluorescence
situ
hybridization
(FISH)
confirmed
lncRNA
Ifngas1
significantly
increased
prefrontal
cortex
(PFC)
adult
mice
after
intraventricular
injection.
can
act
molecular
sponge
miR-21a-3p
play
regulatory
role
through
miR-21a-3p/PI3K/AKT
axis.
Conclusion
We
demonstrated
have
ability
confer
neuroprotection
functional
restoration,
attenuation
neuroinflammation,
inhibition
neuronal
apoptosis,
promotion
vitro
vivo.
hADSC-Exos-derived
IFNG-AS1
acts
facilitates
via
signaling
pathway,
thereby
exerting
effect.
Our
findings
suggest
potential
avenue
individuals
ASD.
Graphical
Biomedical Materials,
Год журнала:
2024,
Номер
19(4), С. 042002 - 042002
Опубликована: Май 2, 2024
Abstract
Porous
tantalum
scaffolds
offer
a
high
degree
of
biocompatibility
and
have
low
friction
coefficient.
In
addition,
their
biomimetic
porous
structure
mechanical
properties,
which
closely
resemble
human
bone
tissue,
make
them
popular
area
research
in
the
field
defect
repair.
With
rapid
advancement
additive
manufacturing,
3D-printed
increasingly
emerged
recent
years,
offering
exceptional
design
flexibility,
as
well
facilitating
fabrication
intricate
geometries
complex
pore
structures
that
similar
to
anatomy.
This
review
provides
comprehensive
description
techniques,
procedures,
specific
parameters
involved
3D
printing
scaffolds.
Concurrently,
summary
osteogenesis
antibacterial
properties
The
use
surface
modification
techniques
drug
carriers
can
enhance
characteristics
Accordingly,
discusses
application
these
materials
clinical
settings.
Multiple
studies
demonstrated
exhibit
corrosion
resistance,
biocompatibility,
osteogenic
properties.
As
result,
they
are
considered
highly
suitable
biomaterials
for
repairing
defects.
Despite
development
scaffolds,
still
encounter
challenges
issues
when
used
implants
applications.
Ultimately,
concise
overview
primary
faced
by
is
offered,
corresponding
insights
promote
further
exploration
this
domain
presented.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101113 - 101113
Опубликована: Июнь 1, 2024
Burns
represent
a
prevalent
global
health
concern
and
are
particularly
susceptible
to
bacterial
infections.
Severe
infections
may
lead
serious
complications,
posing
life-threatening
risk.
Near-infrared
(NIR)-assisted
photothermal
antibacterial
combined
with
antioxidant
hydrogel
has
shown
significant
potential
in
the
healing
of
infected
wounds.
However,
existing
agents
typically
metal-based,
complicated
synthesize,
or
pose
biosafety
hazards.
In
this
study,
we
utilized
plant-derived
blackcurrant
extract
(B)
as
natural
source
for
both
properties.
By
incorporating
B
into
G-O
crosslinked
through
Schiff
base
reaction
between
gelatin
(G)
oxidized
pullulan
(O),
resulting
G-
