Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 2015 - 2039

Published: Jan. 1, 2023

Increasing data reveals that gelatin has been methacrylated is involved in a variety of physiologic processes are important for therapeutic interventions. Gelatin methacryloyl (GelMA) hydrogel highly attractive hydrogels-based bioink because its good biocompatibility, low cost, and photo-cross-linking structure useful cell survivability monitoring. Methacrylated established itself as typical composition with extensive biomedical applications. Recent advances GelMA have focused on integrating them bioactive functional nanomaterials, the goal improving GelMA's physical, chemical, biological properties. ability to modify characteristics due synthesis technique also makes it choice soft hard tissues. become an independent or supplementary technology musculoskeletal problems. Here, we systematically review mechanism-of-action, uses, challenges future direction disorders. We give overview nanocomposite different applications disorders, such osteoarthritis, intervertebral disc degeneration, bone regeneration, tendon disorders so on.

Language: Английский

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3D printing for bone repair: Coupling infection therapy and defect regeneration

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 471, P. 144537 - 144537

Published: June 30, 2023

Language: Английский

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Hydrogel loaded with thiolated chitosan modified taxifolin liposome promotes osteoblast proliferation and regulates Wnt signaling pathway to repair rat skull defects

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 336, P. 122115 - 122115

Published: April 2, 2024

Language: Английский

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Precision Pore Structure Optimization of Additive Manufacturing Porous Tantalum Scaffolds for Bone Regeneration : A proof-of-concept study

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122756 - 122756

Published: Aug. 15, 2024

Language: Английский

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Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 17, 2024

Abstract Background The transplantation of exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs) has emerged as a prospective cellular-free therapeutic intervention for the treatment neurodevelopmental disorders (NDDs), well autism spectrum disorder (ASD). Nevertheless, efficacy hADSC exosome ASD remains to be verified, and underlying mechanism action unclear. Results exosomal long non-coding RNAs (lncRNAs) umbilical cord (hUCMSC) were sequenced 13,915 729 lncRNAs obtained, respectively. present in hADSC-Exos encompass those found hUCMSC-Exos are associated with neurogenesis. biodistribution mouse brain ventricles organoids was tracked, cellular uptake evaluated both vivo vitro. promote neurogenesis organoid ameliorate social deficits model BTBR T + tf/J (BTBR). Fluorescence situ hybridization (FISH) confirmed lncRNA Ifngas1 significantly increased prefrontal cortex (PFC) adult mice after intraventricular injection. can act molecular sponge miR-21a-3p play regulatory role through miR-21a-3p/PI3K/AKT axis. Conclusion We demonstrated have ability confer neuroprotection functional restoration, attenuation neuroinflammation, inhibition neuronal apoptosis, promotion vitro vivo. hADSC-Exos-derived IFNG-AS1 acts facilitates via signaling pathway, thereby exerting effect. Our findings suggest potential avenue individuals ASD. Graphical

Language: Английский

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Evaluation of biological performance of 3D printed trabecular porous tantalum spine fusion cage in large animal models

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 185 - 195

Published: Jan. 1, 2025

Language: Английский

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3D-printed porous tantalum artificial bone scaffolds: fabrication, properties, and applications

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042002 - 042002

Published: May 2, 2024

Abstract Porous tantalum scaffolds offer a high degree of biocompatibility and have low friction coefficient. In addition, their biomimetic porous structure mechanical properties, which closely resemble human bone tissue, make them popular area research in the field defect repair. With rapid advancement additive manufacturing, 3D-printed increasingly emerged recent years, offering exceptional design flexibility, as well facilitating fabrication intricate geometries complex pore structures that similar to anatomy. This review provides comprehensive description techniques, procedures, specific parameters involved 3D printing scaffolds. Concurrently, summary osteogenesis antibacterial properties The use surface modification techniques drug carriers can enhance characteristics Accordingly, discusses application these materials clinical settings. Multiple studies demonstrated exhibit corrosion resistance, biocompatibility, osteogenic properties. As result, they are considered highly suitable biomaterials for repairing defects. Despite development scaffolds, still encounter challenges issues when used implants applications. Ultimately, concise overview primary faced by is offered, corresponding insights promote further exploration this domain presented.

Language: Английский

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Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101113 - 101113

Published: June 1, 2024

Burns represent a prevalent global health concern and are particularly susceptible to bacterial infections. Severe infections may lead serious complications, posing life-threatening risk. Near-infrared (NIR)-assisted photothermal antibacterial combined with antioxidant hydrogel has shown significant potential in the healing of infected wounds. However, existing agents typically metal-based, complicated synthesize, or pose biosafety hazards. In this study, we utilized plant-derived blackcurrant extract (B) as natural source for both properties. By incorporating B into G-O crosslinked through Schiff base reaction between gelatin (G) oxidized pullulan (O), resulting G-

Language: Английский

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Study on injectable silver-incorporated calcium phosphate composite with enhanced antibacterial and biomechanical properties for fighting bone cement-associated infections

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 227, P. 113382 - 113382

Published: May 27, 2023

Language: Английский

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Chitosan and hyaluronic acid based injectable dual network hydrogels - Mediating antimicrobial and inflammatory modulation to promote healing of infected bone defects

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133124 - 133124

Published: June 17, 2024

Language: Английский

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