Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 28, 2024
The incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms treatment methods. Due to the heterogeneous structure and biological characteristics cartilage subchondral bone, integration repair still a challenge.
Язык: Английский
BMEMat, Год журнала: 2023, Номер 1(4)
Опубликована: Сен. 2, 2023
Abstract Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate with structures reconstruct the microenvironment fulfill satisfying repair effects. In this review article, we first discuss various strategies design construction of promote defect repair, especially including structural scaffold integration bioactive substances together application external stimuli. We then roles artificial intelligence medical imaging aiding treatment. Finally, point out challenges future outlooks developing multifunctional scaffolds, aiming provide insights improving regeneration efficacy accelerating translation.
Язык: Английский
Процитировано
51
Bioactive Materials, Год журнала: 2024, Номер 34, С. 338 - 353
Опубликована: Янв. 5, 2024
The osteochondral defects (OCDs) resulting from the treatment of giant cell tumors bone (GCTB) often present two challenges for clinicians: tumor residue leading to local recurrence and non-healing OCDs. Therefore, this study focuses on developing a double-layer PGPC-PGPH scaffold using shell-core structure nanofibers achieve "spatiotemporal control" treating OCDs caused by GCTB. It addresses key challenges: eliminating after excision stimulating regeneration in OCD cases. With shell layer protoporphyrin IX (PpIX)/gelatin (GT) inner cores containing chondroitin sulfate (CS)/poly(lactic-co-glycolic acid) (PLGA) or hydroxyapatite (HA)/PLGA, coaxial electrospinning technology was used create structured PpIX/GT-CS/PLGA PpIX/GT-HA/PLGA nanofibers. These were shattered into nano-scaled short fibers, then combined with polyethylene oxide hyaluronan formulate distinct 3D printing inks. upper consists ink, lower is made allowing creation technique. After GCTB lesion removal, surgically implanted sonosensitizer PpIX undergoes sonodynamic therapy selectively damage tissue, effectively eradicating residual tumors. Subsequently, thermal effect accelerates degradation release CS HA within core layer, promoting stem differentiation cartilage tissues at site correct anatomical position. This innovative provides temporal control anti-tumor followed tissue repair spatial precise regeneration.
Язык: Английский
Процитировано
20
Advanced Industrial and Engineering Polymer Research, Год журнала: 2024, Номер unknown
Опубликована: Май 1, 2024
Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.
Язык: Английский
Процитировано
17
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(10), С. 280 - 280
Опубликована: Сен. 25, 2024
Bone tissue regeneration is a rapidly evolving field aimed at the development of biocompatible materials and devices, such as scaffolds, to treat diseased damaged osseous tissue. Functional scaffolds maintain structural integrity provide mechanical support defect site during healing process, while simultaneously enabling or improving through amplified cellular cues between scaffold native tissues. Ample research on functionalization has been conducted improve scaffold–host interaction, including fabrication techniques, biomaterial selection, surface modifications, integration bioactive molecular additives, post-processing modifications. Each these methods plays crucial role in not only but actively participate process bone joint surgery. This review provides state-of-the-art, comprehensive overview scaffold-based strategies used engineering, specifically for regeneration. Critical issues obstacles are highlighted, applications advances described, future directions identified.
Язык: Английский
Процитировано
14
Materials Today Bio, Год журнала: 2024, Номер 25, С. 100962 - 100962
Опубликована: Янв. 22, 2024
Transforming growth factor-β1 (TGF-β1) is essential for cartilage regeneration, but its susceptibility to enzymatic denaturation and high cost limit application. Herein, we report Ac-LIANAKGFEFEFKFK-NH2 (LKP), a self-assembled peptide nanofiber hydrogel that can mimic the function of TGF-β1. The LKP simple synthesize, in vitro experiments confirmed good biocompatibility cartilage-promoting ability. However, hydrogels suffer from poor mechanical properties are prone fragmentation; therefore, prepared series injectable composite scaffolds (SF-GMA/LKP) by combining with glycidyl methacrylate (GMA)-modified silk fibroin (SF). SF-GMA/LKP instantaneously induced in-situ filling defects and, at same time, relied on interaction between SF-GMA prolong duration action LKP. SF-GMA/LKP10 SF-GMA/LKP20 had best effect neocartilage subchondral bone reconstruction. This scaffold be used high-quality repair.
Язык: Английский
Процитировано
8
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(2), С. 2791 - 2813
Опубликована: Янв. 6, 2025
Transplantation of bone implants is currently recognized as one the most effective means treating defects. Biobased and biodegradable polyester composites combine good mechanical degradable properties polyester, thereby providing an alternative for implant materials. Bone tissue engineering (BTE) accelerates defect repair by simulating microenvironment. Composite scaffolds support formation further accelerate process repair. The introduction 3D printing technology enables preparation to be more precise, reproducible, flexible, which a very promising development. This review presents physical BTE summarizes strategies adopted domestic international scholars improve based on biobased polyester/ceramic in recent years. In addition, future development prospects field challenges expanding production clinical applications are presented.
Язык: Английский
Процитировано
1
Bioactive Materials, Год журнала: 2023, Номер 32, С. 177 - 189
Опубликована: Окт. 11, 2023
Reconstruction of subarticular bone defects is an intractable challenge in orthopedics. The simultaneous repair cancellous defects, fractures, and cartilage damage ideal surgical outcome. 3D printed porous anatomical WE43 (magnesium with 4 wt% yttrium 3 rare earths) scaffolds have many advantages for repairing such including good biocompatibility, appropriate mechanical strength, customizable shape structure, biodegradability. In a previous investigation, we successfully enhanced the corrosion resistance samples via high temperature oxidation (HTO). present study, explored feasibility effectiveness HTO-treated accompanied by split fractures vitro vivo experiments. After HTO treatment, dense layer mainly composed Y2O3 Nd2O3 formed on surface scaffolds. addition, majority grains were equiaxed, average grain size 7.4 μm. Cell rabbit experiments confirmed non-cytotoxicity biocompatibility implantation inside their structures could be maintained more than 12 weeks without penetration 6 penetration. During postoperative follow-up period up to 48 weeks, radiographic examinations histological analysis revealed that abundant gradually regenerated along scaffold degradation, stable osseointegration between new residues. MRI images further demonstrated no evidence any obvious cartilage, ligaments, or menisci, confirming absence traumatic osteoarthritis. Moreover, finite element biomechanical tests verified was conducive uniform distribution. conclusion, applying exhibited favorable effects possessing great potential clinical application.
Язык: Английский
Процитировано
17
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Ноя. 20, 2023
Mechanical stimuli regulate the chondrogenic differentiation of mesenchymal stem cells and homeostasis chondrocytes, thus affecting implant success in cartilage tissue engineering. The mechanical microenvironment plays fundamental roles maturation maintenance natural articular cartilage, progression osteoarthritis Hence, engineering attempts to mimic this environment vivo obtain implants that enable a superior regeneration process. However, specific type loading, its optimal regime, underlying molecular mechanisms are still under investigation. First, review delineates composition structure indicating morphology chondrocytes components extracellular matrix differ from each other resist forces three top-to-bottom overlapping zones. Moreover, results research experiments clinical trials focusing on effect compression, fluid shear stress, hydrostatic pressure, osmotic pressure presented critically evaluated. As key direction, latest advances involved transduction external signals into biological discussed. These sensed by receptors cell membrane, such as primary cilia, integrins, ion channels, which next activate downstream pathways. Finally, biomaterials with various modifications properties self-designed bioreactors for experiment vitro outlined. An improved understanding biomechanically driven is expected lead efficient repair degeneration disease.
Язык: Английский
Процитировано
16
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 154797 - 154797
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
5
Biomaterials, Год журнала: 2025, Номер 317, С. 123084 - 123084
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0