Laser
powder
bed
fusion
(L-PBF)
of
WE43
magnesium
alloy
has
a
promising
application
prospect
in
the
fields
lightweight
parts
and
biodegradable
implants.
Grain
refinement
these
components
is
expected
for
high
strength
controlled
biodegradation,
however,
grain
structure
sensitive
to
composition
processing.
L-PBF
exhibited
significant
diversity
on
microstructure
properties
with
fluctuation
composition,
influencing
mechanism
remained
unclear.
In
this
study,
samples
were
fabricated
formation
quality
using
four
different
powders,
which
content
Nd
Zr
purposely
adjusted.
Their
microstructure,
tensile
corrosion
resistance
characterized.
specimens
composed
fine
equiaxed
grains
obtained
from
Mg-3.56Y-2.45Nd-1.14Gd-0.40Zr
powder,
achieving
ultimate
316
MPa
elongation
15%.
With
minor
decrease
content,
was
still
range
present
standards
WE43,
respectively
abnormal
growth
coarse
columnar
grains,
leading
tremendous
deterioration
mechanical
resistance.
During
multiple
layers
solidification,
promoted
columnar-to-equiaxed
transition
generated
finer
while
exerted
pinning
effect
heat
affected
zone
keep
growth.
The
results
firstly
demonstrate
influence
change
alloying
elements
performance,
indicate
that
stricter
compositional
standard
necessary
achieve
reliable
process.
Bioactive Materials,
Год журнала:
2024,
Номер
40, С. 597 - 623
Опубликована: Авг. 15, 2024
Tissue
engineering
technology
has
advanced
rapidly
in
recent
years,
offering
opportunities
to
construct
biologically
active
tissues
or
organ
substitutes
repair
even
enhance
the
functions
of
diseased
and
organs.
Tissue-engineered
scaffolds
rebuild
extracellular
microenvironment
by
mimicking
matrix.
Fibrin-based
possess
numerous
advantages,
including
hemostasis,
high
biocompatibility,
good
degradability.
Fibrin
provide
an
initial
matrix
that
facilitates
cell
migration,
differentiation,
proliferation,
adhesion,
also
play
a
critical
role
cell-matrix
interactions.
are
now
widely
recognized
as
key
component
tissue
engineering,
where
they
can
facilitate
defect
repair.
This
review
introduces
properties
fibrin,
its
composition,
structure,
biology.
In
addition,
modification
cross-linking
modes
fibrin
discussed,
along
with
various
forms
commonly
used
engineering.
We
describe
biofunctionalization
fibrin.
provides
detailed
overview
use
applications
skin,
bone,
nervous
tissues,
novel
insights
into
future
research
directions
for
clinical
treatment.
Bioactive Materials,
Год журнала:
2024,
Номер
41, С. 293 - 311
Опубликована: Июль 24, 2024
Magnesium
alloys,
noted
for
their
substantial
mechanical
strength
and
exceptional
biocompatibility,
are
increasingly
being
considered
use
in
biodegradable
implants.
However,
rapid
degradation
significant
hydrogen
release
have
limited
applications
orthopaedics.
In
this
study,
a
novel
Mg-RE-Sr
alloy
was
created
by
friction
stir
processing
to
modify
its
microstructure
enhance
performance.
Through
microstructural
characterization,
the
effectively
refined
grains,
accelerated
re-dissolution
of
precipitates,
ensured
uniform
distribution
these
phases.
The
processed
demonstrated
improved
comprehensive
properties,
with
an
International Journal of Extreme Manufacturing,
Год журнала:
2024,
Номер
7(2), С. 022002 - 022002
Опубликована: Ноя. 14, 2024
Highlights
Exploring
personalized
biomedical
metal
implants
through
additive
manufacturing
(AM).
Presenting
new
load-bearing
and
biodegradable
alloys
for
implants.
Showcasing
AI
4D
printing
advancements
in
material
properties.
AM’s
roles
various
medical
fields.
Highlighting
perspectives
of
implant
technology
improved
patient
care.
Computation,
Год журнала:
2024,
Номер
12(4), С. 74 - 74
Опубликована: Апрель 4, 2024
Three-dimensional
porous
scaffolds
are
substitutes
for
traditional
bone
grafts
in
tissue
engineering
(BTE)
applications
to
restore
and
treat
injuries
defects.
The
use
of
computational
modelling
is
gaining
momentum
predict
the
parameters
involved
healing
cell
seeding
procedures
perfusion
bioreactors
reach
final
goal
optimal
growth.
Computational
based
on
finite
element
method
(FEM)
fluid
dynamics
(CFD)
two
standard
methodologies
utilised
investigate
equivalent
mechanical
properties
scaffolds,
as
well
flow
characteristics
inside
respectively.
success
a
simulation
hinges
selection
relevant
mathematical
model
with
proper
initial
boundary
conditions.
This
review
paper
aims
provide
insights
researchers
regarding
appropriate
(FE)
models
different
materials
CFD
regimes
bioreactors.
Thus,
these
FEM/CFD
may
help
create
efficient
designs
by
predicting
their
structural
haemodynamic
responses
prior
vitro
vivo
(TE)
applications.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101635 - 101635
Опубликована: Март 5, 2025
Magnesium-related
bone
implants
have
garnered
significant
attention
in
the
treatment
of
defects.
The
applications
magnesium
promoting
repair
mainly
include
degradable
magnesium-based
scaffolds
owing
to
its
special
physical
properties
and
composite
materials
modified
by
ions
because
biological
activity.
Although
numerous
studies
confirmed
unique
application
advantages
efficacy
repair,
some
obvious
shortcomings
persist,
including
rapid
degradation
scaffolds.
In
this
review,
deficiencies
alloys
construction
orthopedic
their
key
influencing
factors
were
summarized;
furthermore,
advanced
improvement
schemes
summarized
analyzed.
Additionally,
strategies
magnesium-modified
are
discussed.
Lastly,
review
incorporates
latest
research
discoveries
on
science,
comprehensively
exploring
mechanism
magnesium's
role
complex
microenvironment
defects
from
multiple
dimensions.
This
paper
provides
a
comprehensive
summary
analysis
cutting-edge
concepts
design
development
implants,
considering
various
perspectives
such
as
functions
magnesium.
Magnesium
(Mg)-based
metallic
glasses
have
emerged
as
a
promising
class
of
biomaterials
for
various
biomedical
applications
due
to
their
unique
properties,
such
high
strength-to-weight
ratio,
good
biocompatibility
and
biodegradability.
The
development
Mg-based
glass
scaffolds
is
particular
interest
tissue
engineering
regenerative
medicine
applications.
However,
the
rate
biodegradability
materials
not
well
controlled
requires
extensive
research
efficient
tissue/bone
regeneration.
This
review
provides
comprehensive
overview
recent
advancements
in
tuneable
with
different
compositions
thin
film
coatings.
It
discusses
structural
biological
mechanical
biodegradation
behavior,
fabrication
techniques
employed
produce
bulk
scaffolds.
Furthermore,
explores
surface
modification
permanent
implants
biodegradable
simulate
regeneration
on
implants.
Optimization
scaffold
design
increase
growth
healing
by
understanding
complex
interactions
between
tissues
predicting
long-term
implant
behavior
using
computational
models
are
reviewed.
challenges
future
directions
this
field
also
discussed,
providing
insights
into
potential
applications,
including
bone
engineering,
wound
healing,
cardiovascular
Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
32, С. 577 - 588
Опубликована: Июль 26, 2024
Laser
powder
bed
fusion
(L-PBF)
of
WE43
magnesium
alloy
has
a
promising
application
prospect
in
the
fields
lightweight
parts
and
biodegradable
implants.
Grain
refinement
these
components
is
expected
for
high
strength
controlled
biodegradation,
however,
grain
structure
sensitive
to
composition
processing.
L-PBF
exhibited
significant
diversity
on
microstructure
properties
with
fluctuation
composition,
influencing
mechanism
remained
unclear.
In
this
study,
samples
were
fabricated
formation
quality
using
four
different
powders,
which
content
Nd
Zr
purposely
adjusted.
Their
microstructure,
tensile
corrosion
resistance
characterized.
specimens
composed
fine
equiaxed
grains
obtained
from
Mg-3.56Y-2.45Nd-1.14Gd-0.40Zr
powder,
achieving
ultimate
316
MPa
elongation
15%.
With
minor
decrease
content,
was
still
range
present
standards
WE43,
respectively
abnormal
growth
coarse
columnar
grains,
leading
tremendous
deterioration
mechanical
resistance.
During
multiple
layers
solidification,
promoted
columnar-to-equiaxed
transition
generated
finer
while
exerted
pinning
effect
heat
affected
zone
keep
growth.
The
results
firstly
demonstrate
influence
change
alloying
elements
performance,
indicate
that
stricter
compositional
standard
necessary
achieve
reliable
process.
