ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(7), С. 4093 - 4113
Опубликована: Июнь 3, 2024
Titanium
(Ti)
and
its
alloys
are
widely
used
biomaterials
in
bone
repair.
Although
these
possess
stable
properties
good
biocompatibility,
the
high
elastic
modulus
low
surface
activity
of
Ti
implants
have
often
been
associated
with
infection,
inflammation,
poor
osteogenesis.
Therefore,
there
is
an
urgent
need
to
modify
implants,
where
changes
morphology
or
coatings
loading
can
confer
specific
functions
help
them
adapt
osseointegration
formation
phase
resist
bacterial
infection.
This
further
ensure
a
healthy
microenvironment
for
regeneration
as
well
promotion
immunomodulation,
angiogenesis,
this
review,
we
evaluated
various
functional
after
modification,
both
terms
static
modifications
dynamic
response
strategies,
mainly
focusing
on
synergistic
effects
antimicrobial
activities
functionalized
osteogenic.
Finally,
current
challenges
future
perspectives
summarized
provide
innovative
effective
solutions
defect
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101277 - 101277
Опубликована: Март 8, 2024
The
use
of
biomedical
metallic
materials
in
research
and
clinical
applications
has
been
an
important
focus
a
significant
area
interest,
primarily
owing
to
their
role
enhancing
human
health
extending
lifespan.
This
article,
particularly
on
titanium-based
alloys,
explores
exceptional
properties
that
can
address
bone
issues
amid
the
growing
challenges
posed
by
aging
population.
Although
stainless
steel,
magnesium-based
cobalt-based
other
are
commonly
employed
medical
applications,
limitations
such
as
toxic
elements,
high
elastic
modulus,
rapid
degradation
rates
limit
widespread
applications.
Therefore,
alloys
have
emerged
top-performing
materials,
gradually
replacing
counterparts
various
article
extensively
examines
highlights
along
with
in-depth
discussion
currently
utilized
inherent
limitations.
To
begin
with,
essential
requirements
for
load-bearing
biomaterials
introduced.
Then,
summarized
compared.
Afterward,
microstructure,
properties,
preparations
explored.
Furthermore,
surface
modification
methods
discussed
enhance
biocompatibility,
wear
resistance
corrosion
resistance.
Finally,
proposes
development
path
conjunction
additive
manufacturing
novel
alloy
nitinol.
Abstract
Surface
modification
is
an
important
approach
to
improve
osseointegration
of
the
endosseous
implants,
however
it
still
desirable
develop
a
facile
yet
efficient
coating
strategy.
Herein,
metal–phenolic
network
(MPN)
proposed
as
multifunctional
nanocoating
on
titanium
(Ti)
implants
for
enhanced
through
early
immunomodulation.
With
tannic
acid
(TA)
and
Sr
2+
self‐assembled
Ti
substrates,
MPN
coatings
provided
bioactive
interface,
which
can
facilitate
initial
adhesion
recruitment
bone
marrow
mesenchymal
stem
cells
(BMSCs)
polarize
macrophage
toward
M2
phenotype.
Furthermore,
TA‐Sr
accelerated
osteogenic
differentiation
BMSCs.
In
vivo
evaluations
further
confirmed
modified
via
generating
favorable
osteoimmune
microenvironment.
general,
these
results
suggest
that
promising
strategy
achieving
better
faster
be
easily
utilized
in
future
clinical
applications.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 306 - 329
Опубликована: Фев. 10, 2024
To
examine
the
16-year
developmental
history,
research
hotspots,
and
emerging
trends
of
zinc-based
biodegradable
metallic
materials
from
perspective
structural
temporal
dynamics.
The
literature
on
in
WoSCC
was
searched.
Historical
characteristics,
evolution
active
topics
development
field
were
analyzed
using
bibliometric
tools
CiteSpace
HistCite.
Over
past
16
years,
metal
has
remained
a
hotspot
stage,
with
extensive
scientific
collaboration.
In
addition,
there
are
45
subject
categories
51
keywords
different
periods,
80
papers
experience
citation
bursts.
Keyword
clustering
anchored
3
subfields,
namely,
#1
plastic
deformation
#4
additive
manufacturing
#5
surface
modification.
keyword
alluvial
map
shows
that
longest-lasting
concepts
mechanical
property,
microstructure,
corrosion
behavior,
etc.,
manufacturing,
modification,
dynamic
recrystallization,
etc.
most
recent
reference
six
subfields.
Namely,
#0
#2
sem,
#3
laser
powder
bed
fusion,
implant,
#7
Zn–1Mg.
results
study
provide
current
status
materials,
which
can
help
researchers
identify
hot
spots
explore
new
directions
field.
Journal of Biological Engineering,
Год журнала:
2023,
Номер
17(1)
Опубликована: Авг. 29, 2023
Abstract
The
use
of
biodegradable
polymers
for
treating
bone-related
diseases
has
become
a
focal
point
in
the
field
biomedicine.
Recent
advancements
material
technology
have
expanded
range
materials
suitable
orthopaedic
implants.
Three-dimensional
(3D)
printing
prevalent
healthcare,
and
while
organ
is
still
its
early
stages
faces
ethical
technical
hurdles,
3D
capable
creating
structures
that
are
supportive
controllable.
technique
shown
promise
fields
such
as
tissue
engineering
regenerative
medicine,
new
innovations
cell
bio-printing
possibilities.
In
clinical
settings,
metals
mainly
used
orthopedics
stomatology.
3D-printed
patient-specific
osteotomy
instruments,
orthopedic
implants,
dental
implants
been
approved
by
US
FDA
use.
Metals
often
to
provide
support
hard
prevent
complications.
Currently,
70–80%
clinically
made
from
niobium,
tantalum,
nitinol,
titanium
alloys,
cobalt-chromium
stainless
steels.
However,
there
increasing
interest
magnesium,
calcium,
zinc,
iron,
with
numerous
recent
findings.
advantages
printing,
low
manufacturing
costs,
complex
geometry
capabilities,
short
fabrication
periods,
led
widespread
adoption
academia
industry.
controllable
represents
cutting-edge
developing
metallic
biomedical
applications.
This
review
explores
existing
biomaterials
printing-based
well
their
applications
medical
devices.
challenges
future
directions
this
also
discussed.
Nano Materials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Two-dimensional
(2D)
materials
have
attracted
considerable
research
interest
due
to
their
precisely
defined
properties
and
versatile
applications.
In
this
realm,
borophene
-
a
single
atomic
sheet
of
boron
atoms
arranged
in
honeycomb
lattice
has
emerged
as
promising
candidate.
While
borophenes
were
theoretically
predicted
unique
structural,
optical,
electronic
properties,
the
experimental
synthesis
crystalline
sheets
was
first
demonstrated
on
metal
substrates
2015,
marking
crucial
milestone.
Since
then,
efforts
focused
controlling
semiconducting
polymorphs
exploring
novel
physical
characteristics.
This
review
aims
explore
potential
2D
materials,
specifically
borophene,
various
technological
fields
such
batteries,
supercapacitors,
fuel
cells,
more.
The
analysis
emphasises
meticulous
scrutiny
techniques
fundamental
importance
realising
borophene's
properties.
Specifically,
high
carrier
mobilities,
tuneable
bandgaps,
exceptional
thermal
conductivity
are
highlighted.
By
providing
comprehensive
outlook
significance
advancing
science
technologies,
contributes
shaping
landscape
material
research.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 207 - 224
Опубликована: Май 6, 2024
Healing
of
fractures
or
bone
defects
is
significantly
hindered
by
overactivated
osteoclasts
and
inhibited
osteogenesis
in
patients
with
abnormal
metabolism.
Current
clinical
approaches
using
titanium
alloys
stainless
steel
provide
mechanical
support
but
have
no
biological
effects
on
regeneration.
Therefore,
designing
fabricating
degradable
metal
materials
sufficient
strength
bidirectional
regulation
both
osteoblasts
a
substantial
challenge.
Here,
this
study
first
reported
an
adaptive
biodegradable
Zn-0.8
Mg
alloy
homeostasis,
which
promotes
osteogenic
differentiation
activating
the
Pi3k/Akt
pathway
inhibits
osteoclast
inhibiting
GRB2/ERK
pathway.
The
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(6), С. 8886 - 8900
Опубликована: Янв. 31, 2025
The
controllable
regulation
of
immune
and
osteogenic
processes
plays
a
critical
role
in
the
modification
biocompatible
materials
for
tissue
regeneration.
In
this
study,
titanium
dioxide-europium
coatings
(MAO/Eu)
were
prepared
on
surface
alloy
(Ti-6Al-4V)
via
one-step
process
combining
microarc
oxidation
(MAO)
situ
doping.
incorporation
Eu
significantly
improved
hydrophilic
mechanical
properties
TiO2
without
altering
their
morphology.
presence
effectively
stimulated
calcium
influx
macrophages
activated
β-catenin
through
wnt/β-catenin
signaling
pathway.
Consequently,
macrophage
M2
polarization
was
accelerated
overexpression
prostaglandin
E2
(PGE2).
Additionally,
Ca2+
promoted
differentiation
MC3T3-E1
cells
synergistic
upregulation
transcription
factors
(e.g.,
AP-1,
BMP-2).
vivo
studies
demonstrated
that
MAO/Eu
enhanced
osseointegration
compared
with
group.
Therefore,
shows
promising
potential
as
an
ideal
coating
implants
offers
effective
immunomodulatory
strategies
improves
bone
integration.
