Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 20, 2024

Язык: Английский

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Chemistry in phase change energy storage: Properties regulation on organic phase change materials by covalent bond modification

Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153359 - 153359

Опубликована: Июнь 21, 2024

Язык: Английский

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Succinate Nanomaterials Boost Tumor Immunotherapy via Activating Cell Pyroptosis and Enhancing MHC-I Expression

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Despite the promising clinical applications of immunotherapy, its effectiveness is often limited by low immune responses and tumor escape. In this study, we introduce a simple drug-free inorganic nanomaterial, sodium succinate (C4H4Na2O4 NPs), prepared using rapid microemulsion method to enhance cancer immunotherapy. The synthesized C4H4Na2O4 NPs can release high concentrations Na+ ions into cells, leading an increase in intracellular osmolarity. This triggers pyroptosis pathway, resulting cellular contents, inflammatory factors, damage-associated molecular patterns, which ultimately boost responses. Furthermore, inhibit escape through upregulating major histocompatibility complex-I (MHC-I) expression. Collectively, significantly growth metastasis pyroptosis-induced activation MHC-I expression upregulation-remitted research offers novel approach treatment that leverages pyroptosis, demonstrating potential for application

Язык: Английский

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Cell death pathways: molecular mechanisms and therapeutic targets for cancer

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Сен. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Язык: Английский

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Biodegradable Monometallic Aluminum as a Biotuner for Tumor Pyroptosis

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(12)

Опубликована: Фев. 1, 2024

Pyroptosis is an effective anti-tumor strategy. However, monometallic pyroptosis biotuners have not been explored until now. Here, we discover for the first time that biodegradable Al can act as a biotuner tumor therapy. pH-sensitive nanoparticles (Al@P) are obtained by equipping polyethylene glycol-b-(poly(methyl methacrylate)-co-poly(4-vinylpyridine), which exert their effect at site without affecting normal cells. The H

Язык: Английский

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Precise photopharmacological eradication of metastatic tumor cells

Disease Models & Mechanisms, Год журнала: 2025, Номер 18(2)

Опубликована: Фев. 1, 2025

ABSTRACT Owing to their high efficacy, antimitotic chemotherapeutics are the mainstay for most cancer treatments. However, these drugs do not discriminate between tumor and healthy cells, thus show dose-limiting toxicity severe adverse effects. To improve treatments, rendering tumor-cell specific is highly desirable. Although various strategies, such as targeted antibody–drug conjugates, aim achieve this goal, identification of a tumor-specific ‘Achilles' heel’ remains challenge. Here, we followed an alternative approach, which does rely on characteristics, but rather uses spatially confined illumination light-activatable microtubule inhibitor SBTubA4P target its cytotoxic activity cells. We demonstrate that localized allows precise eradication disseminated sarcoma cells in zebrafish xenografts without inducing systemic toxicity. In addition already-described light-dependent inhibition dynamics by SBTubA4P, our data indicate molecule creates reactive oxygen species upon UV illumination, significantly increases valuable precision oncology toolbox, constitute well-suited model investigate photoactivatable compounds vivo.

Язык: Английский

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From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge?

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3349 - 3360

Опубликована: Март 1, 2025

Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation Gasdermin proteins, which membrane pores, leading to rapid rupture and release inflammatory molecules. Unlike other types death, pyroptosis has distinct mechanisms plays complex role in chronic intestinal diseases, including bowel disease, fibrosis, infectious enteritis, colorectal cancer. This review comprehensively examines how influences disease development progression while exploring therapeutic potential targeting pyroptosis-related pathways. Moreover, interplay between gut microbiota summarized, highlighting its critical pathogenesis disorders. A deeper understanding these diseases may provide valuable insights for future research contribute innovative strategies gastroenterology.

Язык: Английский

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Forms of Non-Apoptotic Cell Death and Their Role in Gliomas—Presentation of the Current State of Knowledge

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1546 - 1546

Опубликована: Июль 11, 2024

In addition to necrosis and apoptosis, the two forms of cell death that have been known for many decades, other non-apoptotic discovered, which also play a role in tumors. Starting with description autophagy more than 60 years ago, newer become important biology tumors, such as ferroptosis, pyroptosis, necroptosis, paraptosis. this review, all oncologically relevant programmed are presented, starting their first descriptions, molecular characteristics, interactions physiology pathophysiology. Based on these current state knowledge about alterations gliomas will be presented. addition, efforts therapeutically influence components discussed. Although research into exact is still at rather early stage, our review clarifies show significant insight understanding them has already gained.

Язык: Английский

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Inducing Pyroptosis and Cuproptosis Using Copper Carriers for ROS-Augmented Effective Cancer Therapy

ACS Materials Letters, Год журнала: 2024, Номер 6(9), С. 4282 - 4290

Опубликована: Авг. 20, 2024

Copper overload shows promise as a therapeutic strategy by disrupting copper homeostasis and inducing cell death pathways. However, challenges include the expulsion of excess from cells. This study introduces ZCCP NPs, three-metal MOF nanoparticles that amplify reactive oxygen species (ROS) to enhance cellular uptake reduce efflux. In tumor microenvironment, NPs decompose in response H+ glutathione (GSH), releasing Zn Co ions increase intracellular ROS. Additionally, TMPyP ligand converts Phlorin under near-infrared (NIR) excitation, raising site temperature increasing cancer susceptibility cuproptosis. Elevated ROS activate NLRP3 inflammasome Caspase-1, leading gasdermin D cleavage pyroptosis. Enhanced generation impairs mitochondrial function reduces efflux protein ATP7A expression, promoting combines pyroptosis cuproptosis for effective treatment.

Язык: Английский

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Biodegradable Monometallic Aluminum as a Biotuner for Tumor Pyroptosis

Angewandte Chemie, Год журнала: 2024, Номер 136(12)

Опубликована: Фев. 1, 2024

Abstract Pyroptosis is an effective anti‐tumor strategy. However, monometallic pyroptosis biotuners have not been explored until now. Here, we discover for the first time that biodegradable Al can act as a biotuner tumor therapy. pH‐sensitive nanoparticles (Al@P) are obtained by equipping polyethylene glycol‐ b ‐(poly(methyl methacrylate)‐co‐poly(4‐vinylpyridine), which exert their effect at site without affecting normal cells. The H 2 and 3+ release Al@P in acidic environment of tumors disrupts redox balance ionic homeostasis cells, thus generating large amounts reactive oxygen species (ROS), leading to caspase‐1 activation, gasdermin D cleavage, IL‐1β/LDH release, induces canonical pyroptotic death. Meanwhile, prodrug Doxorubicin (Pro‐DOX) successfully loaded onto (Al@P‐P) be activated ROS DOX further improving tumor‐killing efficiency. Ultimately, Al@P‐P degradable exhibits efficient inhibition.

Язык: Английский

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